Recombinant Human ACE2 Protein (ECD, AA 20-707), C-Avi/His-Tagged, non-biotinylated

• Cat.No.: ACE2-24H
• Product Overview: Recombinant Human ACE2 Protein (ECD, AA 20-707) with C-Avi/His tag (non-biotinylated) was expressed in HEK293.

Specification

• Description: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.
• Source: HEK293
• Species: Human
• Tag: His&Avi
• Form: Liquid
• Protein length: AA 20-707
• AA Sequence: TIEEQAKTFLDKFNHEAEDLFYQSS LASWNYNTNITEENVQNMNNAGDKW SAFLKEQSTLAQMYPLQEIQNLTVK LQLQALQQNGSSVLSEDKSKRLNTI LNTMSTIYSTGKVCNPDNPQECLLL EPGLNEIMANSLDYNERLWAWESWR SEVGKQLRPLYEEYVVLKNEMARAN HYEDYGDYWRGDYEVNGVDGYDYSR GQLIEDVEHTFEEIKPLYEHLHAYV RAKLMNAYPSYISPIGCLPAHLLGD MWGRFWTNLYSLTVPFGQKPNIDVT DAMVDQAWDAQRIFKEAEKFFVSVG LPNMTQGFWENSMLTDPGNVQKAVC HPTAWDLGKGDFRILMCTKVTMDDF LTAHHEMGHIQYDMAYAAQPFLLRN GANEGFHEAVGEIMSLSAATPKHLK SIGLLSPDFQEDNETEINFLLKQAL TIVGTLPFTYMLEKWRWMVFKGEIP KDQWMKKWWEMKREIVGVVEPVPHD ETYCDPASLFHVSNDYSFIRYYTRT LYQFQFQEALCQAAKHEGPLHKCDI SNSTEAGQKLFNMLRLGKSEPWTLA LENVVGAKNMNVRPLLNYFEPLFTW LKDQNKNSFVGWSTDWSPYADQSIK VRISLKSALGDKAYEWNDNEMYLFR SSVAYAMRQYFLKVKNQMILFGEED VRVANLKPRISFNFFVTAPKNVSDI IPRTEVEKAIRMS
• Purity: > 90% as determined by SDS-PAGE
• Storage: Stored and shipped at -80 centigrade
• Storage Buffer: PBS, pH 7.4

Gene Information

• Gene Name: ACE2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 [ Homo sapiens ]
• Official Symbol: ACE2
• Synonyms: ACE2; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin I converting enzyme 2; angiotensin-converting enzyme homolog; ACEH
• Gene ID: 59272
• mRNA Refseq: NM_021804
• Protein Refseq: NP_068576
• MIM: 300335
• UniProt ID: Q9BYF1