Description : |
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Tag-free |
Form : |
Liquid |
Protein Length : |
AA 20-708 |
AA Sequence : |
MTIEEQAKTFLDKFNHEAEDLFYQS SLASWNYNTNITEENVQNMNNAGDK WSAFLKEQSTLAQMYPLQEIQNLTV KLQLQALQQNGSSVLSEDKSKRLNT ILNTMSTIYSTGKVCNPDNPQECLL LEPGLNEIMANSLDYNERLWAWESW RSEVGKQLRPLYEEYVVLKNEMARA NHYEDYGDYWRGDYEVNGVDGYDYS RGQLIEDVEHTFEEIKPLYEHLHAY VRAKLMNAYPSYISPIGCLPAHLLG DMWGRFWTNLYSLTVPFGQKPNIDV TDAMVDQAWDAQRIFKEAEKFFVSV GLPNMTQGFWENSMLTDPGNVQKAV CHPTAWDLGKGDFRILMCTKVTMDD FLTAHHEMGHIQYDMAYAAQPFLLR NGANEGFHEAVGEIMSLSAATPKHL KSIGLLSPDFQEDNETEINFLLKQA LTIVGTLPFTYMLEKWRWMVFKGEI PKDQWMKKWWEMKREIVGVVEPVPH DETYCDPASLFHVSNDYSFIRYYTR TLYQFQFQEALCQAAKHEGPLHKCD ISNSTEAGQKLFNMLRLGKSEPWTL ALENVVGAKNMNVRPLLNYFEPLFT WLKDQNKNSFVGWSTDWSPYADQSI KVRISLKSALGDKAYEWNDNEMYLF RSSVAYAMRQYFLKVKNQMILFGEE DVRVANLKPRISFNFFVTAPKNVSD IIPRTEVEKAIRMSR |
Purity : |
> 80% as determined by SDS-PAGE |
Storage : |
Stored and shipped at -80 centigrade |
Storage Buffer : |
50 mM Tris, 250 mM NaCl, pH 8.0 |