Recombinant Mouse ACE2 Protein, His-tagged

• Cat.No.: ACE2-35M
• Product Overview: Recombinant Mouse Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression systemand the target gene encoding Gln18-Thr740 is expressed with a 10His tag at the C-terminus.

Specification

• Species: Mouse
• Source: Human Cells
• Tag: His
• Protein Length: 18-740 a.a.
• Description: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
• Form: Supplied as a 0.2 um filtered solution of 25 mM Tris-HCl, 150mM NaCl, 1mM ZnCl2, pH 7.5.
• AA Sequence: Gln18-Thr740
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Shipping: Dry ice/ice packs

Gene Information

• Gene Name: Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 [ Mus musculus (house mouse) ]
• Official Symbol: ACE2
• Synonyms: Angiotensin Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
• Gene ID: 70008
• mRNA Refseq: NM_027286.4
• Protein Refseq: NP_081562.2
• UniProt ID: Q8R0I0