acvr1
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  • Official Full Name
  • activin A receptor, type I
  • Background
  • Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta);superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor;serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors;are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a;transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are;essential for signaling; and type II receptors are required for binding ligands and for expression of type I;receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I;receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional;response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia;ossificans progressive.
  • Synonyms
  • ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1; ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; se
Cat.#:ACVR1-1022HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR1 Protein, MYC/DDK-tagged
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Cat.#:ACVR1-527HTag:His/Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR1 Protein, His/Fc-tagged
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Cat.#:ACVR1-01HTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type I
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Cat.#:ACVR1-1408HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type I
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Cat.#:ACVR1-1583HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Activin A Receptor, Type I
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Cat.#:ACVR1-199HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ACVR1 Protein, His-tagged
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Cat.#:ACVR1-201HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ACVR1(R206H), GST-tagged
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Cat.#:ACVR1-239HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type I, GST-tagged, Active
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Cat.#:ACVR1-245HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ACVR1 Protein, GST-His-tagged
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Cat.#:ACVR1-246HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ACVR1 Protein, GST-tagged
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Cat.#:ACVR1-247HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACVR1 Protein, GST-tagged
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Cat.#:ACVR1-2595HTag:N/A
Source (Host):BTI-Tn-5B1-4 cellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type I
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Cat.#:ACVR1-2743HTag:N/A
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type I
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Cat.#:ACVR1-32HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK2 (Q207D), GST-tagged
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Cat.#:ACVR1-33HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK2 (Q207E), GST-tagged
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Cat.#:ACVR1-37HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ACVR1, GST-tagged
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Cat.#:ACVR1-38HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK2 Mutant (Q207E), GST-tagged
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Cat.#:ACVR1-489HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Activin A Receptor, Type I, Fc Chimera
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Cat.#:ACVR1-526HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ACVR1, Fc-tagged, Biotinylated
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Cat.#:ACVR1-5680HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACVR1 protein, His-tagged
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Cat.#:ACVR1-5681HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACVR1 protein, His & GST-tagged
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Cat.#:ACVR1-9172HTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ACVR1
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Cat.#:Acvr1-5682MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Acvr1 protein, His-tagged
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Cat.#:Acvr1-775MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Acvr1, Fc-His tagged
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Cat.#:Acvr1-8719RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Acvr1, Fc tagged
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Cat.#:ACVR1-8812CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR1, Fc tagged
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Cat.#:ACVR1-230RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACVR1 Protein, His-tagged
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Cat.#:ACVR1-160CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine ACVR1, Fc-tagged
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Cat.#:ACVR1-161CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine ACVR1, His-tagged
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Cat.#:ACVR1-300CTag:FC/His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine ACVR1, His tagged
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Cat.#:ACVR1-301CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine ACVR1, Fc tagged
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Cat.#:ACVR1-6129CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACVR1
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Cat.#:ACVR1-984HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type I, His-tagged
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Cat.#:ACVR1-3097HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR1 cell lysate
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Cat.#:ACVR1-478HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ACVR1 cell lysate
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Cat.#:ACVR1-2686MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ACVR1 cell lysate
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Cat.#:ACVR1-1305RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ACVR1 cell lysate
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Cat.#:ACVR1-1232CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR1 cell lysate
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Cat.#:ACVR1-967CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine ACVR1 cell lysate
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Involved Pathway

ACVR1 involved in several pathways and played different roles in them. We selected most pathways ACVR1 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
AMH; TNFRSF19; CCL19B; IL10; IL3RA; TGFBR1; NGFRB; IFNA8; TGFB3; FLT4
TGF-beta signaling pathway
ID2B; TGIF2; ROCK1; ACVR1; ROCK2B; BMPR2; PPP2R1A; SMAD2; INHBA; FST
Signaling pathways regulating pluripotency of stem cells
WNT3A; BMPR2; BMP2; MAP2K2; ID1; NODAL; SMAD1; IGF1R; FGFR4; ACVR1C

Protein Function

ACVR1 has several biochemical functions, for example, ATP binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR1 itself. We selected most functions ACVR1 had, and list some proteins which have the same functions with ACVR1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PBK; DCK; XRCC3; PLK3; EHD3; VWA8; RYK; KIF26A; ABCC2; QARS
Function SMAD binding
Related Protein HIPK2; SNW1; SOD3; RNF111; COL3A1; CTNNB1; TGFBR3; YY1; SKIB; SMAD2
Function activin binding
Related Protein ENG; FST; SMURF1; ACVR2B; ACVR1; FKBP1A; SMAD7; ACVRL1; FSTL3; TGFBR3
Function contributes_to activin receptor activity, type I
Related Protein ACVR1; ACVRL1
Function metal ion binding
Related Protein DNAJA2; CYP4F14; TM9SF1; SNAI1A; EIF2S2; REST; PKMYT1; ZNF606; ATP1A2A; MYCBP2
Function peptide hormone binding
Related Protein SLC40A1; GIPR; PTH1R; GHRHR; INHBA; AGTR2; OXTR; MC4R; ECE1; GALR2
Function protein binding
Related Protein BCL2L2; CRHBP; ZNF133; IARS; ZFAND5; ZNF365; FOXJ2; KIAA1267; ACKR4; DDOST
Function protein homodimerization activity
Related Protein SMAD3; SLC4A1; EPHX2; MIXL1; ATG7; PEX7; TCF4; JUP; GDF6; NR0B2
Function protein kinase activity
Related Protein PHKG1A; DCLK3; CDK13; NEK10; AKT1; CSNK1D; JAK2B; PTK6B; FYNB; GC3
Function protein serine/threonine kinase activity
Related Protein CSNK2A2; NLK; NUAK1; KALRN; MAP2K4; SGK3; CSNK1DB; AKT2L; PRKCB; DCKL1B
Function receptor signaling protein serine/threonine kinase activity
Related Protein ACVR1C; OXSR1B; BMPR1AA; BMPR2B; STK25B; OXSR1A; STK39; ACVR1BA; ACVR1B; STK24B
Function transforming growth factor beta binding
Related Protein HYAL2; TGFBR1; ITGAV; LTBP1; ACVR1; THBS1; CD109; TGFBR3; TGFB3; ENG
Function transforming growth factor beta receptor activity, type I
Related Protein TGFBR1; BMPR1B; ACVR1
Function transmembrane receptor protein serine/threonine kinase activity
Related Protein TGFBR2; ACVR2AA; BMPR1BA; BMPR1B; TGFBR1A; ACVR1B; TGFBR1B; ACVR1L; BMPR2B; BMPR2A

Interacting Protein

ACVR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR1.
Smad6; Rab17; Rhod; Fbxo30; Ikbkb; Chn1; Nek8; Ubxn1; Fancl; Rab3b; Rhebl1; Plekhb1; TGFBR1; linkable pd173955 analogue; bosutinib; dasatinib; crizotinib