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ACVR1

  • Official Full Name

    activin A receptor, type I

  • Overview

    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta);superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor;serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors;are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a;transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are;essential for signaling; and type II receptors are required for binding ligands and for expression of type I;receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I;receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional;response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia;ossificans progressive.
  • Synonyms

    ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1; ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; se;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • BTI-Tn-5B1-4 Cell
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Nicotiana Benthamiana
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • hFc
  • Fc
  • Fc|His
  • Flag
  • GST
  • GST|His
  • HIS
  • His (Fc)
  • Avi
  • His|Fc
  • His|GST
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACVR1-526H Active Recombinant Human ACVR1, Fc-tagged, Biotinylated Human Cell Fc
Human ACVR1-246H Active Recombinant Human ACVR1 Protein, GST-tagged Insect Cell GST
Human ACVR1-37H Active Recombinant Human ACVR1, GST-tagged Sf9 Insect Cell GST
Human ACVR1-245H Active Recombinant Human ACVR1 Protein, GST-His-tagged Insect Cell GST/His
Human ACVR1-38H Active Recombinant Human ALK2 Mutant (Q207E), GST-tagged Sf9 Insect Cell GST
Human ACVR1-201H Active Recombinant Human ACVR1(R206H), GST-tagged Sf9 Insect Cell GST
Human ACVR1-01H Recombinant Human Activin A Receptor, Type I Sf9 Insect Cell N/A
Human ACVR1-32H Recombinant Human ALK2 (Q207D), GST-tagged Sf9 Insect Cell GST
Human ACVR1-527H Active Recombinant Human ACVR1 Protein, His/Fc-tagged HEK293 His/Fc Met 1-Val 124
Human ACVR1-2595H Recombinant Human Activin A Receptor, Type I BTI-Tn-5B1-4 Cell N/A
Human ACVR1-489H Recombinant Human Activin A Receptor, Type I, Fc Chimera HEK293 Fc
Human ACVR1-33H Recombinant Human ALK2 (Q207E), GST-tagged Sf9 Insect Cell GST
Human ACVR1-1408H Recombinant Human Activin A Receptor, Type I Insect Cell N/A
Human ACVR1-2743H Recombinant Human Activin A Receptor, Type I Nicotiana Benthamiana N/A
Human ACVR1-239H Recombinant Human Activin A Receptor, Type I, GST-tagged, Active Sf9 Insect Cell GST
Human ACVR1-247H Recombinant Human ACVR1 Protein, GST-tagged Wheat Germ GST
Human ACVR1-9172H Recombinant Human ACVR1 Insect Cell N/A 123 amino acids
Human ACVR1-5680H Recombinant Human ACVR1 protein, His-tagged E.coli His Ile208~Lys340 (Accession # Q04771)
Human ACVR1-984H Recombinant Human Activin A Receptor, Type I, His-tagged Sf9 Insect Cell GST
Human ACVR1-5681H Recombinant Human ACVR1 protein, His & GST-tagged E.coli His/GST Ile208~Lys340 (Accession # Q04771)
Human ACVR1-199H Active Recombinant Human ACVR1 Protein, His-tagged Insect Cell His
Human ACVR1-1583H Recombinant Human Activin A Receptor, Type I Mammalian cells N/A
Human ACVR1-478HCL Recombinant Human ACVR1 cell lysate Insect Cell N/A
Human ACVR1-3097HCL Recombinant Human ACVR1 cell lysate Human Cell N/A
Human ACVR1-5028H Recombinant Human ACVR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACVR1-1022H Recombinant Human ACVR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ACVR1-0159H Recombinant Human ACVR1 Protein (T172-C509), His tagged Insect Cell His T172-C509
Human ACVR1-864HF Recombinant Full Length Human ACVR1 Protein, GST-tagged In Vitro Cell Free System GST 509 amino acids
Human ACVR1-26485TH Recombinant Human ACVR1, His-tagged HIS
Human ACVR1-170H Recombinant Human ACVR1 Protein, His-tagged Human Cell His
Human ACVR1-274H-B Recombinant Human ACVR1 Protein Pre-coupled Magnetic Beads HEK293
Human ACVR1-1452HFL Recombinant Full Length Human ACVR1 Protein, C-Flag-tagged Mammalian cells Flag
Human ACVR1-0494H Recombinant Human ACVR1 Protein (Ile208-Lys340), N-GST-tagged E.coli N-GST Ile208-Lys340
Human ACVR1-274H Recombinant Human ACVR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ACVR1-0158H Recombinant Human ACVR1 Protein (T172-C509), Tag Free Insect Cell No tag T172-C509
Human ACVR1-0495H Recombinant Human ACVR1 Protein (Met21-Val124 ), C-His-tagged Mammalian cells C-His Met21-Val124
Mouse Acvr1-775M Active Recombinant Mouse Acvr1 protein(Met1-Glu123), His&hFc-tagged HEK293 C-His&hFc Met1-Glu123
Mouse Acvr1-5682M Recombinant Mouse Acvr1 protein, His-tagged E.coli His Ile208~Lys340 (Accession # P37172)
Mouse ACVR1-2686MCL Recombinant Mouse ACVR1 cell lysate Human Cell N/A
Mouse Acvr1-814M Recombinant Mouse Acvr1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Acvr1-8719R Recombinant Rat Acvr1 protein, hFc-tagged HEK293 hFc Met1-Glu123
Rat ACVR1-1305RCL Recombinant Rat ACVR1 cell lysate Human Cell N/A
Canine ACVR1-160C Recombinant Canine ACVR1, Fc-tagged Human Cell Fc Met1-Glu123
Canine ACVR1-301C Recombinant Canine ACVR1, Fc tagged Human Cell His
Canine ACVR1-161C Recombinant Canine ACVR1, His-tagged Human Cell His Met1-Glu123
Canine ACVR1-300C Recombinant Canine ACVR1, His tagged Human Cell Fc/His
Canine ACVR1-967CCL Recombinant Canine ACVR1 cell lysate Human Cell N/A
Cynomolgus Monkey ACVR1-8812C Recombinant Cynomolgus ACVR1, Fc tagged Human Cell Fc
Cynomolgus Monkey ACVR1-1232CCL Recombinant Cynomolgus ACVR1 cell lysate Human Cell N/A
Mus musculus (Mouse) RFL-27610MF Recombinant Full Length Mouse Activin Receptor Type-1(Acvr1) Protein, His-Tagged E.coli expression system His Full Length (21-509)
Rattus norvegicus (Rat) RFL-20406RF Recombinant Full Length Rat Activin Receptor Type-1(Acvr1) Protein, His-Tagged E.coli expression system His Full Length (21-509)
Rhesus Macaque ACVR1-230R Recombinant Rhesus monkey ACVR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ACVR1-58R-B Recombinant Rhesus Macaque ACVR1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ACVR1-58R Recombinant Rhesus Macaque ACVR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ACVR1-6129C Recombinant Chicken ACVR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACVR1 Related Research Area

ACVR1 involved in several pathways and played different roles in them. We selected most pathways ACVR1 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionLEPB;PRP2;IL13RA1;CSF2;GM13304;IL19;CRLF2;IL12B;CCL11
TGF-beta signaling pathwayBMP2B;RPS6KB2;BMPR1AB;SMAD3;BMPR1BA;LEFTY1;ID3;BMPR1AA;MAPK1
Signaling pathways regulating pluripotency of stem cellsSMARCAD1;WNT7B;IGF1R;FGF2;PIK3R5;ACVR1C;IGF1;HNF1A;MAP2K1

ACVR1 has several biochemical functions, for example, ATP binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR1 itself. We selected most functions ACVR1 had, and list some proteins which have the same functions with ACVR1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRKAA1;KIF13B;CAMK2D;AKT2;OXSR1B;GRK1A;ULK4;TOR1;CAMK2D1
SMAD bindingPRDM16;ACVR1;SKOR1A;EID2;PML;ACVRL1;SKOR1B;CREBBP;FOXH1
activin bindingACVRL1;ACVR2B;FKBP1A;ACVR1;ENG;SMAD7;FSTL3;SMURF1;FST
contributes_to activin receptor activity, type IACVR1;ACVRL1
metal ion bindingZNF443;RAB11FIP4;ZNF791;MAT1A;PHF23B;MAT2AL;GMEB2;LACTB2;ZNF445
peptide hormone bindingRXFP2;OXTR;MC3R;HCRTR2;PTH1RB;AGTR1A;EDNRB;AGTR2;GALR3
protein bindingMLF1IP;MXD1;ZNF488;INTS12;PPP1R37;ZHX1;PRKCE;FGF19;CD1A
protein homodimerization activityHOGA1;S100A1;CD2;S100A5;CACYBP;PRMT2;USH1G;ASMT;CCDC103
protein kinase activityPLK5;KITB;LIMK1A;PINK1;ROCK2B;CAMK1DB;NAT1;PDPK1B;AVP
protein serine/threonine kinase activityCSNK1G2B;GRK1A;ATM;CAMK1DA;MAP4K2;MAP3K12;RIPK4;C9orf96;ACVR1BA
receptor signaling protein serine/threonine kinase activityTGFBR1A;BMPR1AA;BMPR2B;STK39;ACVR1B;STK24B;OXSR1B;ACVR2AA;BMPR1B
transforming growth factor beta bindingTGFBR1;HYAL2;ACVR1;THBS1;TGFBR3;LTBP4;ACVRL1;ITGAV;TGFBR2
transforming growth factor beta receptor activity, type ITGFBR1;ACVR1;BMPR1B
transmembrane receptor protein serine/threonine kinase activityACVR1B;BMPR2B;ALPK2;BMPR1AB;TGFBR1A;ACVR1L;BMPR1A;ACVR2A;BMPR2A

ACVR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR1.

Smad6; Rab17; Rhod; Fbxo30; Ikbkb; Chn1; Nek8; Ubxn1; Fancl; Rab3b; Rhebl1; Plekhb1; TGFBR1; linkable pd173955 analogue; bosutinib; dasatinib; crizotinib

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