ACVR1 Protein, activin A receptor, type I

ACVR1

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ACVR1

Official Full Name activin A receptor, type I
Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta);superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor;serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors;are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a;transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are;essential for signaling; and type II receptors are required for binding ligands and for expression of type I;receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I;receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional;response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia;ossificans progressive.
Synonyms ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1; ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; se
    • Species :
    • Canine
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • BTI-Tn-5B1-4 Cell
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Nicotiana Benthamiana
    • NSO
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ACVR1-01H Recombinant Human Activin A Receptor, Type I Sf9 Insect Cell N/A
    Human ACVR1-1022H Recombinant Human ACVR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ACVR1-1408H Recombinant Human Activin A Receptor, Type I Insect Cell N/A
    Human ACVR1-1583H Recombinant Human Activin A Receptor, Type I NSO N/A
    Human ACVR1-199H Recombinant Human ACVR1 Protein, His-tagged Insect Cell His
    Human ACVR1-201H Recombinant Human ACVR1(R206H), GST-tagged Sf9 Insect Cell GST
    Human ACVR1-239H Recombinant Human Activin A Receptor, Type I, GST-tagged, Active Sf9 Insect Cell GST
    Human ACVR1-245H Recombinant Human ACVR1 Protein, GST-His-tagged Insect Cell GST/His
    Human ACVR1-246H Recombinant Human ACVR1 Protein, GST-tagged Insect Cell GST
    Human ACVR1-247H Recombinant Human ACVR1 Protein, GST-tagged Wheat Germ GST
    Human ACVR1-2595H Recombinant Human Activin A Receptor, Type I BTI-Tn-5B1-4 Cell N/A
    Human ACVR1-26485TH Recombinant Human ACVR1, His-tagged HIS
    Human ACVR1-2743H Recombinant Human Activin A Receptor, Type I Nicotiana Benthamiana N/A
    Human ACVR1-3097HCL Recombinant Human ACVR1 cell lysate Human Cell N/A
    Human ACVR1-32H Recombinant Human ALK2 (Q207D), GST-tagged Sf9 Insect Cell GST
    Human ACVR1-33H Recombinant Human ALK2 (Q207E), GST-tagged Sf9 Insect Cell GST
    Human ACVR1-37H Recombinant Human ACVR1, GST-tagged Sf9 Insect Cell GST
    Human ACVR1-38H Recombinant Human ALK2 Mutant (Q207E), GST-tagged Sf9 Insect Cell GST
    Human ACVR1-478HCL Recombinant Human ACVR1 cell lysate Insect Cell N/A
    Human ACVR1-489H Recombinant Human Activin A Receptor, Type I, Fc Chimera HEK293 Fc
    Human ACVR1-526H Recombinant Human ACVR1, Fc-tagged, Biotinylated Human Cell Fc
    Human ACVR1-527H Recombinant Human ACVR1 Protein, His/Fc-tagged HEK293 His/Fc
    Human ACVR1-5680H Recombinant Human ACVR1 protein, His-tagged E.coli His
    Human ACVR1-5681H Recombinant Human ACVR1 protein, His & GST-tagged E.coli His/GST
    Human ACVR1-9172H Recombinant Human ACVR1 Insect Cell N/A
    Human ACVR1-984H Recombinant Human Activin A Receptor, Type I, His-tagged Sf9 Insect Cell GST
    Mouse ACVR1-2686MCL Recombinant Mouse ACVR1 cell lysate Human Cell N/A
    Mouse Acvr1-5682M Recombinant Mouse Acvr1 protein, His-tagged E.coli His
    Mouse Acvr1-775M Recombinant Mouse Acvr1, Fc-His tagged Human Cell Fc/His
    Rat ACVR1-1305RCL Recombinant Rat ACVR1 cell lysate Human Cell N/A
    Rat Acvr1-8719R Recombinant Rat Acvr1, Fc tagged Human Cell Fc
    Cynomolgus Monkey ACVR1-1232CCL Recombinant Cynomolgus ACVR1 cell lysate Human Cell N/A
    Cynomolgus Monkey ACVR1-8812C Recombinant Cynomolgus ACVR1, Fc tagged Human Cell Fc
    Rhesus Macaque ACVR1-230R Recombinant Rhesus monkey ACVR1 Protein, His-tagged Mammalian Cell His
    Canine ACVR1-160C Recombinant Canine ACVR1, Fc-tagged Human Cell Fc
    Canine ACVR1-161C Recombinant Canine ACVR1, His-tagged Human Cell His
    Canine ACVR1-300C Recombinant Canine ACVR1, His tagged Human Cell Fc/His
    Canine ACVR1-301C Recombinant Canine ACVR1, Fc tagged Human Cell His
    Canine ACVR1-967CCL Recombinant Canine ACVR1 cell lysate Human Cell N/A
    Chicken ACVR1-6129C Recombinant Chicken ACVR1 Mammalian Cell His

    ACVR1 involved in several pathways and played different roles in them. We selected most pathways ACVR1 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL11; IFNW1; VEGFAA; Ccl21c; XCR1; IL17RA; CCL4L1; VEGFA; THPO; CXCL12B
    TGF-beta signaling pathway BMP2; AMHR2; THBS1; BMPR1BB; TFDP1A; BMPR1AA; RBL1; BAMBIB; NOG3; SMAD4
    Signaling pathways regulating pluripotency of stem cells NRAS; NEUROG1; MAPK13; MAPK1; FGF2; PCGF3; FZD1; PAX6; WNT8B; ID4

    ACVR1 has several biochemical functions, for example, ATP binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR1 itself. We selected most functions ACVR1 had, and list some proteins which have the same functions with ACVR1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding UBE2D2; CSNK2A2; PRKACAA; GRK7A; P2RX2; P2RX6; ATP1A1; UBE2U; MAP3K13; YSK4
    SMAD binding SKOR1; BMPR1A; COL1A2; PURB; TGFBR3; SMAD2; TOB1; SNW1; CTNNB1; TGFBR1
    activin binding FST; FSTL3; ACVRL1; SMAD7; ACVR2B; FKBP1A; SMURF1; TGFBR3; ACVR1; ENG
    contributes_to activin receptor activity, type I ACVRL1; ACVR1
    metal ion binding BSN; SEMG2; NRP2A; NR2F1B; GGTA1; ITGA5; ZNF597; ZNF37A; FIZ1; MAP3K15
    peptide hormone binding GHRHR; INHBA; PTH1RB; PTH1RA; GALR2; GALR1; GALR3; PRLR; RXFP2; ANXA5
    protein binding ADAM1B; RAC1; KCTD1; DNAJB5; MAGEA2B; RECQL; TPD52L3; EIF2B5; CDK7; A2M
    protein homodimerization activity YARS2; PDGFB; LRP6; SLC22A6; PYCARD; TRPM8; SRM; RENBP; AMBP; RQCD1
    protein kinase activity BUB1B; DYRK1A; GSK3AA; TBCK; MYO3A; MAPKAPK2A; TLK1B; ROCK2A; PRKACAB; SRPK1
    protein serine/threonine kinase activity HIPK4; CSNK1D; RPS6KAL; AKT3; AKT3A; VRK2; MAP4K1; MAPK6; TTN; PDIK1L
    receptor signaling protein serine/threonine kinase activity BMPR2A; PANK1A; SBK3; STK26; BMPR1AB; BMPR1B; STK25B; ACVR1; ACVR2B; BMPR1BB
    transforming growth factor beta binding THBS1; ENG; VASN; LTBP1; TGFBR2; ACVRL1; HYAL2; ITGAV; TGFB3; CD109
    transforming growth factor beta receptor activity, type I BMPR1B; TGFBR1; ACVR1
    transmembrane receptor protein serine/threonine kinase activity ACVR2A; ALPK2; BMPR1BB; ACVR2AA; TGFBR2; BMPR2A; BMPR1AB; ACVR1; ACVRL1; BMPR1AA

    ACVR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR1.

    Smad6; Rab17; Rhod; Fbxo30; Ikbkb; Chn1; Nek8; Ubxn1; Fancl; Rab3b; Rhebl1; Plekhb1; TGFBR1; linkable pd173955 analogue; bosutinib; dasatinib; crizotinib

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