Recombinant Human Activin A Receptor, Type I

• Cat.No.: ACVR1-1408H
• Product Overview: Recombinant human Activin A Receptor, Type I was expressed inInsect cells. MW=26 kDa.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Description: Human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues, belonging to the TGF-β family. It exhibits a wide range of biological activity including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.
• Specific Activity: ≥5×10⁵ U/mg.
• Product Format: Sterile filtered, lyophilized.
• Stabilizer: None.
• Purity: >95% (SDS-PAGE, HPLC).
• Endotoxin Level: <0.1 ng/μg (1 EU/μg).
• Buffer: Citric acid (10 mM, pH 3.0).
• Biological Activity: The ED₅₀ of ≤2 ng/mL was determined by its ability to inhibit the proliferation of mouse MPC-11 cells. It corresponds to a specific activity of ≥5×10⁵ U/mg.
• Reconstitution: We recommend a quick spin followed by reconstitution in deionized sterile-filtered water to a concentration of 50μg/mL. This solution can be stored at 4°C for 1 month or at –20°C for future use. It is recommended that further dilutions be made in PBS containing 2 mg/mL albumin and stored at –20°C.
• Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at –20°C for at least two years. Reconstituted Human Activin A should be stored in working aliquots at –20°C. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: ACVR1 activin A receptor, type I [ Homo sapiens ]
• Synonyms: ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; OTTHUMP00000204604; OTT HUMP000002 04626; hydroxyalkyl-protein kinase; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; EC 2.7.11.30
• Gene ID: 90
• mRNA Refseq: NM_001105
• Protein Refseq: NP_001096
• MIM: 102576
• UniProt ID: Q04771
• Chromosome Location: 2q23-q24
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: ATP binding; SMAD binding; activin binding; activin receptor activity, type I; follistatin binding; gnesium ion binding; manganese ion binding; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity; transforming growth factor beta binding