casp1
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  • Official Full Name
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence
  • Background
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.
  • Synonyms
  • CASP 1; CASP-1; CASP1; CASP1_HUMAN; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase-1 subunit p10; Caspase1; ICE; IL 1 beta converting enzyme; IL 1BC; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; IL1BC; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; P45; OTTHUMP00000045728; OTTHUMP00000232029; OTTHUMP00000232030; OTTHUMP00000232031; OTTHUMP00000232032; OTTHUMP00000232033; OTTHUMP00000232034; OTTHUMP00000232036
Cat.#:CASP1-0411HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP1 Protein, GST-Tagged
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Cat.#:Casp1-0413MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp1 Protein
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Cat.#:CASP1-596HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP1
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Cat.#:CASP1-10729HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP1, GST-tagged
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Cat.#:CASP1-173HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP1 Protein, His-tagged
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Cat.#:CASP1-174HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP1 Protein, His-tagged
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Cat.#:CASP1-180HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP1 protein, His-tagged
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Cat.#:CASP1-2748MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP1 Protein
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Cat.#:Casp1-7151MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp1 protein, His-tagged
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Cat.#:Casp1-577RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Casp1 protein, His-tagged
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Cat.#:CASP1-7152PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CASP1 protein, His-tagged
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Cat.#:CASP1-7840HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP1 293 Cell Lysate
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Cat.#:CASP1-7841HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP1 293 Cell Lysate
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Involved Pathway

CASP1 involved in several pathways and played different roles in them. We selected most pathways CASP1 participated on our site, such as NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NOD-like receptor signaling pathway
LOC100033925; MAPK14B; MAPK13; CCL5; IL8L2; BIRC3; CXCL8B.3; MAPK3; CCL2; IKBKB
Cytosolic DNA-sensing pathway
TBK1; IFN-a; IFNA8; Ifna15; RIPK1L; IFI202B; NFKBIA; POLR3K; IKBKB; AIM2
Amyotrophic lateral sclerosis (ALS)
MAPK13; RAC1; SOD1; BAD; GRIA1; PPP3CC; TNFRSF1B; GRIN2D; NEFH; NOS1
Salmonella infection
ACTB1; CDC42; KLC1A; IL1B; NLRC4; RAC1B; PFN1; ARPC5LA; ARPC5LB; TLR5
Pertussis
IRF3; GNAI1; C4BPB; CALM2; IRAK4; C1QB; TRAF6; Casp3; NFKB1; C1S
Legionellosis
HSPA1A; CASP9; IL12A; SAR1A; CXCL2; Casp3; EEF1A2; TLR2; CASP7; ITGB2
Influenza A
LOC780933; BLB1; HLA-DQA1; CCL5; FAS; IFNA7; IFNA1; ADAR; NUP98; IFNA13

Protein Function

CASP1 has several biochemical functions, for example, cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP1 itself. We selected most functions CASP1 had, and list some proteins which have the same functions with CASP1. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activator activity involved in apoptotic process
Related Protein APAF1; NLRP12; NOD1; CTSH; CARD8; CTSC; RPS27L; BAD; BCL2L13; NLRP1
Function cysteine-type endopeptidase activity
Related Protein CTSLL; CTSO; PDIA3; CASP1; USP42; MALT1; CTSSB.2; USP17L2; USP30; CASPC
Function NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis
Related Protein CASPB; CASPBL; PSD; CASP4; CASP1; CASP12; CASP5; CASPA
Function endopeptidase activity
Related Protein PSMB6; ACE; Ren1; CTSH; MME; PSMA4; ECE1; KLK1B5; APH1B; PSMB5
Function protein binding
Related Protein LOXL2; CASP14; SOX1; ZNF259; PRKAA1; LCE1B; PUS7L; RABAC1; C5orf30; CCAR1

Interacting Protein

CASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP1.
NLRC4; PYCARD; VAC14; IL1A; AIM2; ATG16L1; RIPK2

CASP1 Related Articles

He, JB; Wang, H; et al. Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy. JOURNAL OF OPHTHALMOLOGY :-(2015).
Hoque, R; Farooq, A; et al. Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor- and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity. GASTROENTEROLOGY 146:1763-1774(2014).