cd46
Share
  • Official Full Name
  • CD46 molecule, complement regulatory protein
  • Background
  • The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
  • Synonyms
  • CD46; CD46 molecule, complement regulatory protein; MCP; TLX; AHUS2; MIC10; TRA2.10; membrane cofactor protein; measles virus receptor; complement membrane cofactor protein; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; CD46 antigen, complement regulatory protein; trophoblast-lymphocyte cross-reactive antigen; antigen identified by monoclonal antibody TRA-2-10; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen);
Cat.#:CD46-2331GTag:His
Source (Host):E. coliSpecies:Guinea Pig
Product nameRecombinant Guinea Pig CD46 Protein (36-316 aa), His-tagged
+Inquiry
Cat.#:CD46-394MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse CD46 Protein (45-329 aa), His-tagged
+Inquiry
Cat.#:CD46-0822HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD46 Protein
+Inquiry
Cat.#:CD46-0823HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD46 Protein, GST-Tagged
+Inquiry
Cat.#:CD46-3962HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD46, His tagged
+Inquiry
Cat.#:CD46-7592HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD46, His-tagged
+Inquiry
Cat.#:CD46-3093MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CD46 Protein
+Inquiry
Cat.#:Cd46-6755MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd46 protein, His & GST-tagged
+Inquiry
Cat.#:CD46-1254RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CD46 Protein
+Inquiry
Cat.#:Cd46-6756RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd46 protein, His & GST-tagged
+Inquiry
Cat.#:CD46-742RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD46 Protein, His-tagged
+Inquiry
Cat.#:CD46-1964HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD46 cell lysate
+Inquiry

Involved Pathway

CD46 involved in several pathways and played different roles in them. We selected most pathways CD46 participated on our site, such as Complement and coagulation cascades, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
PLAUR; CFH; F10; C9; MBL2; CR1; FGG; Hc; C8G; CR2
Measles
IFNA16; IFNA10; AKT2; IRAK4; EIF2AK1; RAB9B; CD3D; PIK3R1; GSK3B; PIK3R5

Protein Function

CD46 has several biochemical functions, for example, cadherin binding, complement binding, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD46 itself. We selected most functions CD46 had, and list some proteins which have the same functions with CD46. You can find most of the proteins on our site.
Function
Related Protein
Function cadherin binding
Related Protein CD46; FXYD5; TBC1D2; TRPC4; CDK5R1; CTNNB1; CTNNA2; PSEN1; GNA13A; P2RX4
Function complement binding
Related Protein C8A; C8G; CD46; CR2; CD59; CFB
Function endopeptidase activity
Related Protein PSMB1; MMP1; KLK1B22; ECE1; REN2; HTRA4; F9; PSEN2; PSMA6B; TPP2
Function enzyme inhibitor activity
Related Protein ATPIF1; ATPIF1B; PRPSAP1; OAZ2A; PLN; APOV1; CSN2; PDE6G; WFIKKN1; APBA3
Function protein binding
Related Protein AKR1C1; JAKMIP2; AGO2; C11orf65; EPHA7; NME3; IRF1; POLDIP3; FBXW11; ECH1
Function receptor activity
Related Protein CRLF1; CD4; VMN1R49; KLRB1B; VMN1R44; MED17; GRIK3; TREM1; GRIN3B; GRIA4B
Function virus receptor activity
Related Protein CXADR; HLA-DRB1; XPR1; SCARB2; ITGB6; SERPINB4; ACE2; PVRL1; IDE; LDLR

Interacting Protein

CD46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD46 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD46.
JAG1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; C3; STK39; EBNA2; q8d1h5_yerpe; carA; toxA; toxB

CD46 Related Articles

Drager, C; Beer, M; et al. Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro. ARCHIVES OF VIROLOGY 160:739-746(2015).
Scambi, C; Ugolini, S; et al. The Local Complement Activation on Vascular Bed of Patients with Systemic Sclerosis: A Hypothesis-Generating Study. PLOS ONE 10:-(2015).