Recombinant Human CD46 Protein, His-tagged
Cat.No. : | CD46-162H |
Product Overview : | Recombinant human CD46 protein with His tag was expressed in HEK293. |
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Description : | The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized |
Molecular Mass : | 33.6 kDa |
Protein length : | 392 |
AA Sequence : | MEPPGRRECPFPSWRFPGLLLAAMV LLLYSFSDACEEPPTFEAMELIGKP KPYYEIGERVDYKCKKGYFYIPPLA THTICDRNHTWLPVSDDACYRETCP YIRDPLNGQAVPANGTYEFGYQMHF ICNEGYYLIGEEILYCELKGSVAIW SGKPPICEKVLCTPPPKIKNGKHTF SEVEVFEYLDAVTYSCDPAPGPDPF SLIGESTIYCGDNSVWSRAAPECKV VKCRFPVVENGKQISGFGKKFYYKA TVMFECDKGFYLDGSDTIVCDSNST WDPPVPKCLKVLPPSSTKPPALSHS VSTSSTTKSPASSASGPRPTYKPPV SNYPGYPKPEEGILDSLDVWVIAVI VIAIVVGVAVICVVPYRYLQRRKKK GTYLTDETHREVKFTSL |
Purity : | > 98% |
Applications : | WB; ELISA; FACS; FC |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | CD46 CD46 molecule, complement regulatory protein [ Homo sapiens (human) ] |
Official Symbol : | CD46 |
Synonyms : | CD46; CD46 molecule, complement regulatory protein; antigen identified by monoclonal TRA 2 10 , CD46 antigen, complement regulatory protein , MCP, membrane cofactor protein (CD46, trophoblast lymphocyte cross reactive antigen) , MIC10; membrane cofactor protein; MGC26544; TLX; TRA2.10; measles virus receptor; complement membrane cofactor protein; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; CD46 antigen, complement regulatory protein; trophoblast-lymphocyte cross-reactive antigen; antigen identified by monoclonal TRA-2-10; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MCP; AHUS2; MIC10; |
Gene ID : | 4179 |
mRNA Refseq : | NM_002389 |
Protein Refseq : | NP_002380 |
MIM : | 120920 |
UniProt ID : | P15529 |
Products Types
◆ Recombinant Protein | ||
CD46-394M | Recombinant Mouse CD46 Protein (45-329 aa), His-tagged | +Inquiry |
CD46-6744H | Recombinant Human CD46 protein, His-tagged | +Inquiry |
CD46-0822H | Recombinant Human CD46 Protein | +Inquiry |
CD46-1591C | Recombinant Canine CD46 protein, His-tagged | +Inquiry |
CD46-2331G | Recombinant Guinea Pig CD46 Protein (36-316 aa), His-tagged | +Inquiry |
◆ Lysates | ||
CD46-1964HCL | Recombinant Human CD46 cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe CD46 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.
With the CD46 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.
Its unique properties make CD46 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.
Q&As (5)
Ask a questionCD46 protein interacts with complement regulatory proteins and immune cells to regulate immune responses and maintain homeostasis.
Potential side effects of targeting CD46 protein for therapy may include disturbances in immune regulation and increased susceptibility to infections.
CD46 protein regulates the activation of complement system and modulates T cell responses, contributing to immune regulation.
Mutations in the CD46 gene have been associated with genetic disorders such as atypical hemolytic uremic syndrome (aHUS) and other complement-related disorders.
CD46 protein has been implicated in cancer progression and treatment resistance, particularly in certain types of leukemia and solid tumors.
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