Cxcl16
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Official Full Name
chemokine (C-X-C motif) ligand 16
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Overview
Chemokine (C-X-C motif) ligand 16 (CXCL16), also known as SR-PSOX, is a transmembrane protein that facilitates uptake of low density lipoproteins by macrophages, resulting in foam cell formation. CXCL16 is found in liver tissue2 and influences the uptake, subcellular localization, and cytokine profile induced by D oligonucleotides. 3 CXCL16 may play a pro- inflammatory role in Inflammatory Bowel Disease (IBD), particularly Crohns disease. -
Synonyms
chemokine (C-X-C motif) ligand 16; SRPSOX; CXCLG16; SR-PSOX; CXCL16; CXC chemokine ligand 16; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; Small-inducible cytokine B16; Transmembrane chemokine CXCL16;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- GMP Proteins
- Cell & Tissue Lysates
- Canine
- Cynomolgus
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293F
- Human Cell
- Human cells
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Yeast
- Biotin
- C
- His
- Fc
- GST
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Cxcl16 Related Articles
- Cxcl16 Related Gene Family
- Cxcl16 Related Research Area
Cxcl16 involved in several pathways and played different roles in them. We selected most pathways Cxcl16 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cxcl16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CXCL13;IL26;CCL3;IFN-a;IL20RB;FLT3;Ifnlr1;CCL7;XCL1 |
| Chemokine signaling pathway | CCL15;CX3CL1;SOS1;CCR6;PLCB4;STAT3;JAK3;PIK3CB;GNG3 |
Cxcl16 has several biochemical functions, for example, chemokine activity, low-density lipoprotein receptor activity, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cxcl16 itself. We selected most functions Cxcl16 had, and list some proteins which have the same functions with Cxcl16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemokine activity | Ccl9;IL8L2;CXL34B.11;CCL34B.9;CXCL3;CCL38A.4;CCL2;CXCL20;CCL38A.5 |
| low-density lipoprotein receptor activity | OLR1;LDLR;LRP12;CXCL16;VLDLR;LRP6 |
| scavenger receptor activity | SCART1;SUSD2;HHIPL1;TMPRSS5;ACKR4;TMPRSS15;LOXL2;CD5;SRCRB4D |
Cxcl16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cxcl16 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cxcl16.
- Q&As
- Reviews
Q&As (7)
Ask a questionCXCL16 acts as both a chemokine and adhesion molecule, guiding immune cell recruitment and facilitating cell-cell interactions.
CXCL16 influences inflammatory and autoimmune diseases, modulating immune cell recruitment and activation.
In tumor immunology, CXCL16 facilitates the infiltration of immune cells into tumors, affecting tumor immunity.
Changes in CXCL16 expression impact kidney function, potentially contributing to the development of renal diseases.
CXCL16 plays a role in atherosclerosis by recruiting immune cells to arterial walls, influencing plaque formation.
CXCL16 regulates T cell and dendritic cell migration and activation, playing a key role in immune responses.
CXCL16 boosts the immune response to pathogens, especially in viral infections, by attracting immune cells.
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