cxcr4
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  • Official Full Name
  • chemokine (C-X-C motif) receptor 4
  • Background
  • This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor;
Cat.#:CXCR4-1175HTag:His|SUMO|Myc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCR4 Protein, His-SUMO/MYC-tagged
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Cat.#:CXCR4-2181HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCR4 Protein, GST-tagged
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Cat.#:CXCR4-1176HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CXCR4 protein isoform 2, His-tagged
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Cat.#:CXCR4-510HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CXCR4 protein, His-tagged
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Cat.#:CXCR4-19HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCR4, Fc-tagged
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Cat.#:CXCR4-503HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CXCR4, His-tagged
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Cat.#:CXCR4-504HTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CXCR4
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Cat.#:CXCR4-5138HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCR4, GST-tagged
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Cat.#:CXCR4-4110MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CXCR4 Protein
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Cat.#:CXCR4-1115RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CXCR4 Protein, His-tagged
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Cat.#:CXCR4-6185CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CXCR4
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Cat.#:CXCR4-7161HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CXCR4 293 Cell Lysate
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Cat.#:Kit-1197Tag:N/A
Source (Host):Species:
Product namecAMP CXCR4 CHO-K1 GPCR Assay Kit
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Cat.#:Kit-1198Tag:N/A
Source (Host):Species:
Product namecAMP CHO-K1 CXCR4 Bioassay Kit
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Cat.#:Kit-1199Tag:N/A
Source (Host):Species:
Product nameCXCR4 Total GPCR Internalization Assay Kit
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Involved Pathway

CXCR4 involved in several pathways and played different roles in them. We selected most pathways CXCR4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFSF15; CSF3R; TNFRSF10D; IL17A; TNFSF18; CXCL1; TNFRSF17; OSTN; EDA2R; IFNE
Chemokine signaling pathway
WASL; MAPK3; Ccl12; STAT2; CXCL2; LOC100033925; PIK3R1; NFKBIB; RAP1B; CX3CR1
Endocytosis
WAS; RAB8A; GRK5; FGFR4; SH3GL3A; ARPC5L; ADRB2A; GRK6; PIP5K1BA; SH3GL3
Axon guidance
RASGEF1A; SEMA3B; ADAM10; EPHB2; EFNB3; COL4A3; ROCK1; ABL1; CXCL12; EPHA2A
Leukocyte transendothelial migration
CLDN5; MYL2; PLCG2; PTPN11; VAV2; VAV1; CTNNA3; CLDN10; JAM3; NOX1
Intestinal i
Il2; ICOS; CD40; TNFSF13; BLA; HLA-DPA1; MHC2DAB; CCL28; HLA-DRB4; ICOSLG
ne network for IgA production
BLB2; CXCR4B; ITGA4; CD28; Il2; H2-AA; CCR10; MADCAM1; CCL28; HLA-DOA
Pathways in cancer
PTGS2; GLI1; IGF1; SLC2A1; WNT8B; FGF1; WNT9A; SKP2; MAPK9; GLI3

Protein Function

CXCR4 has several biochemical functions, for example, C-X-C chemokine receptor activity, G-protein coupled receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR4 itself. We selected most functions CXCR4 had, and list some proteins which have the same functions with CXCR4. You can find most of the proteins on our site.
Function
Related Protein
Function C-X-C chemokine receptor activity
Related Protein CXCR2; CXCR3; CCBP2; CXCR3.1; CXCR4; CXCR7; CXCR5; CCR9A; CXCR4A; CXCR6
Function G-protein coupled receptor activity
Related Protein NPFFR1L3; OPN1SW2; SMO; LPAR5; LPAR6; GRM8B; OR5V1; OPN1MW2; V2RH32; GPR149
Function actin binding
Related Protein ARPC5L; MICAL2; FLII; WASB; PARVAA; WASH1; MARCKSL1; MYO1G; DMD; KLHL33
Function coreceptor activity
Related Protein RAMP2; IGSF1; ZP2; ACVR2A; PVRL1; CXCR6; LY96; LRP5; CD86; CD80
Function cytokine binding
Related Protein CHRD; CNTFR; Fzd4; CSF1R; NRP1; KITA; PARK7; TNFRSF11A; GBP1; CSF1RA
Function myosin light chain binding
Related Protein MYO19; MYOC; SPATA6; CXCR4
Function protein binding
Related Protein MRE11A; ACMSD; ZNF436; LNX2B; POC5; SIRT7; RPL23A; AGXT2L2; GRM6; AARSD1
Function ubiquitin binding
Related Protein HSPB1; RNF31; UBXN2B; BRAP; OTUB1B; OTUB2; USP13; FAN1; OTUB1; CRY2
Function ubiquitin protein ligase binding
Related Protein WASH; PIAS4; PRDX6; KCNQ3; UBE2L3; MAGEA2; ARRB2; TRAF5; UBE2U; GSK3B
Function virus receptor activity
Related Protein IDE; CD46; CXCR4; PVR; NCAM1; SLC10A1; ICAM1; HLA-DRB1; CD209A; HSPA1A

Interacting Protein

CXCR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR4.
DBN1; CD74; MYH9; Dbn1; CD164; CCR5

CXCR4 Related Articles

Thapa, D; Ghosh, R; et al. Chronic inflammatory mediators enhance prostate cancer development and progression. BIOCHEMICAL PHARMACOLOGY 94:53-62(2015).
Wang, RSE; Liu, T; et al. An Immunosuppressive Antibody-Drug Conjugate. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137:3229-3232(2015).

CXCR4 Related Gene Family

Chemokines Cytokines