Recombinant Human CXCR4 Protein, His-tagged

• Cat.No.: CXCR4-01H
• Product Overview: Recombinant Human CXCR4 Protein, fused to His-tag, was expressed in Human cells.

Specification

• Description: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: Human cells
• Species: Human
• Tag: His
• Form: Supplied as a 0.2 μm filtered solution in PBS (pH 7.4)
• AA Sequence: MSIPLPLLQIYTSDNYTEEMGSGDY DSMKEPCFREENANFNKIFLPTIYS IIFLTGIVGNGLVILVMGYQKKLRS MTDKYRLHLSVADLLFVITLPFWAV DAVANWYFGNFLCKAVHVIYTVNLY SSVLILAFISLDRYLAIVHATNSQR PRKLLAEKVVYVGVWIPALLLTIPD FIFANVSEADDRYICDRFYPNDLWV VVFQFQHIMVGLILPGIVILSCYCI IISKLSHSKGHQKRKALKTTVILIL AFFACWLPYYIGISIDSFILLEIIK QGCEFENTVHKWISITEALAFFHCC LNPILYAFLGAKFKTSAQHALTSVS RGSSLKILSKGKRGGHSSVSTESES SSFHSSHHHHHHHHHH
• Endotoxin: unexamined
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 1.0 mg/ml

Gene Information

• Gene Name: CXCR4 C-X-C motif chemokine receptor 4 [ Homo sapiens (human) ]
• Official Symbol: CXCR4
• Synonyms: FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; WHIMS1; D2S201E
• Gene ID: 7852
• mRNA Refseq: NM_003467.3
• Protein Refseq: NP_003458.1
• MIM: 162643
• UniProt ID: P61073