Recombinant Human CXCR4

Cat.No. : CXCR4-504H
Product Overview : Recombinant Human CXCR4 was expressed in wheat germ.
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Description : This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Source : Wheat germ
Species : Human
Form : Liquid
Molecular Mass : 39.7 kDa
AA Sequence : MEGISIYTSDNYTEEMGSGDYDSMK EPCFREENANFNKIFLPTIYSIIFL TGIVGNGLVILVMGYQKKLRSMTDK YRLHLSVADLLFVITLPFWAVDAVA NWYFGNFLCKAVHVIYTVNLYSSVL ILAFISLDRYLAIVHATNSQRPRKL LAEKVVYVGVWIPALLLTIPDFIFA NVSEADDRYICDRFYPNDLWVVVFQ FQHIMVGLILPGIVILSCYCIIISK LSHSKGHQKRKALKTTVILILAFFA CWLPYYIGISIDSFILLEIIKQGCE FENTVHKWISITEALAFFHCCLNPI LYAFLGAKFKTSAQHALTSVSRGSS LKILSKGKRGGHSSVSTESESSSFH SS
Applications : Antibody Production; Functional Study; Compound Screening
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 25 mM Tris-HCl of pH 8.0 containing 2% glycerol.
Publication :
The development and characterization of SDF1α-elastin-like-peptide nanoparticles for wound healing (2016)
Gene Name : CXCR4 chemokine (C-X-C motif) receptor 4 [ Homo sapiens ]
Official Symbol : CXCR4
Synonyms : CXCR4; chemokine (C-X-C motif) receptor 4; chemokine (C X C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CD184; D2S201E; fusin; HM89; HSY3RR; LESTR; NPY3R; NPYR; NPYY3R; CXC-R4; CXCR-4; CD184 antigen; SDF-1 receptor; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; FB22; LAP3; LCR1; WHIM; NPYRL
Gene ID : 7852
mRNA Refseq : NM_001008540
Protein Refseq : NP_001008540
MIM : 162643
UniProt ID : P61073
Chromosome Location : 2q21
Pathway : Axon guidance; Cardiac Progenitor Differentiation; Class A/1 (Rhodopsin-like receptors)
Function : C-X-C chemokine receptor activity; G-protein coupled receptor activity; myosin light chain binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CXCR4 participate in chemotaxis and migration of immune cells, particularly in the context of the immune response? 01/26/2022

CXCR4 participates in chemotaxis and migration of immune cells, facilitating their movement toward specific tissues during the immune response.

Are there specific chemokines or ligands that CXCR4 binds to, influencing its role in immune cell activation and recruitment? 01/09/2020

Specific chemokines or ligands, such as CXCL12, bind to CXCR4, influencing its role in immune cell activation and recruitment.

In which cellular compartments is CXCR4 predominantly localized, especially within immune cells? 06/14/2019

CXCR4 is predominantly localized on the cell surface of immune cells, particularly within the membrane of T cells and monocytes.

What diseases or conditions are associated with dysregulation or abnormal expression of CXCR4, especially in the immune system? 03/27/2019

Dysregulation or abnormal expression of CXCR4 is associated with diseases such as cancer, HIV/AIDS, and autoimmune disorders, particularly affecting immune cell function.

Are there therapeutic implications or potential targets related to CXCR4 in diseases involving immune dysregulation and inflammation? 06/28/2018

There are potential therapeutic implications related to CXCR4 in diseases involving immune dysregulation and inflammation, making it a target for drug development.

How does CXCR4 contribute to the regulation of inflammatory responses and immune cell trafficking in various tissues? 08/30/2017

CXCR4 contributes to the regulation of inflammatory responses and immune cell trafficking in various tissues, influencing the outcome of immune reactions.

What is the primary function of C-X-C chemokine receptor type 4 (CXCR4) in cellular processes and immune responses? 06/27/2016

C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in cellular processes, primarily contributing to immune responses and cell migration.

Customer Reviews (3)

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04/07/2022

    The responsive customer support team provided quick resolutions to any queries or issues we encountered.

    10/28/2021

      The product's cost-effectiveness and clear instructions were instrumental in our experimental design.

      10/29/2018

        We found the product's straightforward protocols highly conducive to seamless integration into our lab work.

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