Recombinant Human CXCR4 Protein, C-hFc tagged
Cat.No. : | CXCR4-011H |
Product Overview : | Recombinant Human CXCR4 Protein with C-hFc tag was expressed in HEK293. |
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Description : | This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Molecular Mass : | The protein has a predicted molecular mass of 30.5 kDa after removal of the signal peptide. The apparent molecular mass of CXCR4-hFc is approximately 35-55 kDa due to glycosylation. |
Purity : | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | 12 months from date of despatch. |
Storage : | Store at -20 to -80 centigrade for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 centigrade (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Reconstitution : | Lyophilized from sterile PBS, pH 7.4. Normally 5 %-8% trehalose is added as protectants before lyophilization. |
Gene Name : | CXCR4 chemokine (C-X-C motif) receptor 4 [ Homo sapiens (human) ] |
Official Symbol : | CXCR4 |
Synonyms : | CXCR4; chemokine (C-X-C motif) receptor 4; chemokine (C X C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CD184; D2S201E; fusin; HM89; HSY3RR; LESTR; NPY3R; NPYR; NPYY3R; CXC-R4; CXCR-4; CD184 antigen; SDF-1 receptor; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; FB22; LAP3; LCR1; WHIM; NPYRL; |
Gene ID : | 7852 |
mRNA Refseq : | NM_001008540 |
Protein Refseq : | NP_001008540 |
MIM : | 162643 |
UniProt ID : | P61073 |
Products Types
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◆ Lysates | ||
CXCR4-7161HCL | Recombinant Human CXCR4 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1199 | CXCR4 Total GPCR Internalization Assay Kit | +Inquiry |
Kit-1198 | cAMP CHO-K1 CXCR4 Bioassay Kit | +Inquiry |
Kit-1197 | cAMP CXCR4 CHO-K1 GPCR Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe responsive customer support team provided quick resolutions to any queries or issues we encountered.
The product's cost-effectiveness and clear instructions were instrumental in our experimental design.
We found the product's straightforward protocols highly conducive to seamless integration into our lab work.
Q&As (7)
Ask a questionCXCR4 participates in chemotaxis and migration of immune cells, facilitating their movement toward specific tissues during the immune response.
Specific chemokines or ligands, such as CXCL12, bind to CXCR4, influencing its role in immune cell activation and recruitment.
CXCR4 is predominantly localized on the cell surface of immune cells, particularly within the membrane of T cells and monocytes.
Dysregulation or abnormal expression of CXCR4 is associated with diseases such as cancer, HIV/AIDS, and autoimmune disorders, particularly affecting immune cell function.
There are potential therapeutic implications related to CXCR4 in diseases involving immune dysregulation and inflammation, making it a target for drug development.
CXCR4 contributes to the regulation of inflammatory responses and immune cell trafficking in various tissues, influencing the outcome of immune reactions.
C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in cellular processes, primarily contributing to immune responses and cell migration.
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