erbb3
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  • Official Full Name
  • ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • Background
  • ErbB3 is a member of the EGFR/erbB receptor tyrosine kinase family. ErbB3 lacks intrinsic kinase activity due to an amino acid substitution within the ATP binding site. Upon heterodimerization with the other erbB family members, erbB3 becomes phosphorylated at multiple tyrosine residues that represent docking sites for downstream signaling proteins, e.g. PI3K, grb7 and shc. The erbB3 cytoplasmic domain contains 6 docking sites for PI3K. Thus, erbB3 is a potent activator of the PI3K/PKB signaling pathway.
  • Synonyms
  • ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;
Cat.#:ERBB3-23HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human ERBB3 Protein
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Cat.#:ERBB3-2117HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 Protein, MYC/DDK-tagged
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Cat.#:ERBB3-3448HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERBB3 Protein, GST-tagged
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Cat.#:ERBB3-383HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERBB3 Protein, His-tagged
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Cat.#:Erbb3-384MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Erbb3 Protein, His-tagged
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Cat.#:Erbb3-470MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Fc-tagged
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Cat.#:ERBB3-2514HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian)
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Cat.#:ERBB3-105HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB3, His-tagged
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Cat.#:ERBB3-127HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 Protein, DDK/His-tagged
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Cat.#:ERBB3-128HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB3 Protein, DDK-tagged
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Cat.#:ERBB3-1613HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human ERBB3
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Cat.#:ERBB3-196HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, His-tagged, C13&N15 Labeled
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Cat.#:ERBB3-197HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 Protein
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Cat.#:ERBB3-207HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, His-tagged
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Cat.#:ERBB3-209HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, His tagged
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Cat.#:ERBB3-232HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, C13&N15-labeled
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Cat.#:ERBB3-26847THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERBB3, His-tagged
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Cat.#:ERBB3-283HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, His-tagged, Biotinylated
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Cat.#:ERBB3-44HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, Fc tagged
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Cat.#:ERBB3-45HTag:Twin-Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 Protein, Twin-Strep tagged
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Cat.#:ERBB3-621HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ERBB3, Fc-tagged, Biotinylated
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Cat.#:ERBB3-7276HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB3, His & GST tagged
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Cat.#:Erbb3-2515MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Erbb3, His tagged
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Cat.#:ERBB3-38MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse ERBB3 Protein, His-tagged
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Cat.#:ERBB3-2133RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ERBB3 Protein
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Cat.#:Erbb3-7436RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb3, Fc tagged
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Cat.#:Erbb3-7437RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb3, His tagged
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Cat.#:ERBB3-1178RTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB3 Protein, Fc-tagged
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Cat.#:ERBB3-1179RTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB3 Protein, His-tagged
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Cat.#:ERBB3-1180RTag:
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB3 Protein
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Cat.#:ERBB3-3461CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ERBB3
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Cat.#:ERBB3-5193HTag:Thyrodoxin/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged
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Cat.#:ERBB3-1216HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), His-tagged
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Cat.#:ERBB3-430HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB3 cell lysate
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Cat.#:ERBB3-939HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 cell lysate
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Cat.#:ERBB3-1765MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ERBB3 cell lysate
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Cat.#:ERBB3-1415RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ERBB3 cell lysate
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Cat.#:ERBB3-1721RCLTag:
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB3 cell lysate
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Involved Pathway

ERBB3 involved in several pathways and played different roles in them. We selected most pathways ERBB3 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
CAMK2D; PAK4; MAPK3; STAT5A; MAPK9; MAP2K2B; CBL; CBLB; NRAS; PTK2AA
Calcium signaling pathway
MYLK; TACR1A; PLCD1; HTR2C; ADCY2B; PTAFR; ADORA2AA; GNA11A; ORAI3; PRKCBB
Endocytosis
VPS28; ARF6B; DNM1A; CHMP1B; ADRB3B; ZFYVE9; RAB11FIP3; CHMP4C; CHMP6B; ACAP3
Proteoglycans in cancer
WNT1; ITGB5; NUDT16L1; AKT1; IL12B; PLCG2; CCND1; WNT2; PRKACB; MMP2
MicroRNAs in cancer
CDCA5; ABCB1; ROCK1; BMPR2; TPM1; TRIM71; FZD3; SIRT1; DNMT3A; TTC6

Protein Function

ERBB3 has several biochemical functions, for example, ATP binding, growth factor binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERBB3 itself. We selected most functions ERBB3 had, and list some proteins which have the same functions with ERBB3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CDC7; PSKH1; NEK3; KATNAL2; MTPAP; DNAJA4; SRR; MYH3; ABCD1; CASKA
Function growth factor binding
Related Protein LIFR; OSMR; ACVR2B; FGFBP2; LTBP2; NKD2; HTRA1A; RHBDF1; NRP2; KDR
Function identical protein binding
Related Protein ATG16L1; CLDN17; LTBR; REG3B; THBS1; PUF60; TYROBP; PKD2; ALDH4A1; HOOK3
Function protein binding
Related Protein CTNNBIP1; SLC30A1; HOXB9; BRK1; SMAGP; DCUN1D4; WDR11; C16orf72; TMEM30B; TMEM14C
Function protein heterodimerization activity
Related Protein PANX1; HSPD1; H2AFZ; SOX5; HGF; MEIS1; POLA2; VOX; STX1A; CASP8
Function protein homodimerization activity
Related Protein FOXP3; OSTA; ENO3; EPHX2; GREM2; ATPIF1; SLC39A13; S100A16; ERCC5; IRAK2
Function protein tyrosine kinase activator activity
Related Protein ABI3A; ERBB3; AFAP1L2; ABI1; ABI1B; CD24; PAK2; ERCC6; GAS6; NRG1
Function NOT protein tyrosine kinase activity
Related Protein ERBB3; RYK; KLHL8; TWF1
Function transmembrane signaling receptor activity
Related Protein CELSR1; TNFRSF10D; IL1R1; MARCO; BAI2; TLR2-1; EVI2A; NFAM1; ICAM1; TLR2

Interacting Protein

ERBB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERBB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERBB3.
ERBB2

ERBB3 Related Articles

Huang, Z; Choi, BK; et al. The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling. ONCOGENE 34:1105-1115(2015).
Nevoltris, D; Lombard, B; et al. Conformational Nanobodies Reveal Tethered Epidermal Growth Factor Receptor Involved in EGFR/ErbB2 Predimers. ACS NANO 9:1388-1399(2015).