erbb3
Share
  • Official Full Name
  • ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • Background
  • ErbB3 is a member of the EGFR/erbB receptor tyrosine kinase family. ErbB3 lacks intrinsic kinase activity due to an amino acid substitution within the ATP binding site. Upon heterodimerization with the other erbB family members, erbB3 becomes phosphorylated at multiple tyrosine residues that represent docking sites for downstream signaling proteins, e.g. PI3K, grb7 and shc. The erbB3 cytoplasmic domain contains 6 docking sites for PI3K. Thus, erbB3 is a potent activator of the PI3K/PKB signaling pathway.
  • Synonyms
  • ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;
Cat.#:ERBB3-23HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human ERBB3 Protein
+Inquiry
Cat.#:ERBB3-2117HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:ERBB3-3448HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERBB3 Protein, GST-tagged
+Inquiry
Cat.#:ERBB3-383HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERBB3 Protein, His-tagged
+Inquiry
Cat.#:Erbb3-384MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Erbb3 Protein, His-tagged
+Inquiry
Cat.#:Erbb3-470MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Fc-tagged
+Inquiry
Cat.#:ERBB3-2514HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian)
+Inquiry
Cat.#:ERBB3-105HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB3, His-tagged
+Inquiry
Cat.#:ERBB3-127HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 Protein, DDK/His-tagged
+Inquiry
Cat.#:ERBB3-128HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB3 Protein, DDK-tagged
+Inquiry
Cat.#:ERBB3-1613HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human ERBB3
+Inquiry
Cat.#:ERBB3-196HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, His-tagged, C13&N15 Labeled
+Inquiry
Cat.#:ERBB3-197HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 Protein
+Inquiry
Cat.#:ERBB3-207HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, His-tagged
+Inquiry
Cat.#:ERBB3-209HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, His tagged
+Inquiry
Cat.#:ERBB3-232HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, C13&N15-labeled
+Inquiry
Cat.#:ERBB3-26847THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERBB3, His-tagged
+Inquiry
Cat.#:ERBB3-283HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, His-tagged, Biotinylated
+Inquiry
Cat.#:ERBB3-44HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3, Fc tagged
+Inquiry
Cat.#:ERBB3-45HTag:Twin-Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 Protein, Twin-Strep tagged
+Inquiry
Cat.#:ERBB3-621HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ERBB3, Fc-tagged, Biotinylated
+Inquiry
Cat.#:ERBB3-7276HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB3, His & GST tagged
+Inquiry
Cat.#:Erbb3-2515MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Erbb3, His tagged
+Inquiry
Cat.#:ERBB3-38MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse ERBB3 Protein, His-tagged
+Inquiry
Cat.#:ERBB3-2133RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ERBB3 Protein
+Inquiry
Cat.#:Erbb3-7436RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb3, Fc tagged
+Inquiry
Cat.#:Erbb3-7437RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb3, His tagged
+Inquiry
Cat.#:ERBB3-1178RTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB3 Protein, Fc-tagged
+Inquiry
Cat.#:ERBB3-1179RTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB3 Protein, His-tagged
+Inquiry
Cat.#:ERBB3-1180RTag:N/A
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB3 Protein
+Inquiry
Cat.#:ERBB3-3461CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ERBB3
+Inquiry
Cat.#:ERBB3-5193HTag:Thyrodoxin|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged
+Inquiry
Cat.#:ERBB3-1216HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), His-tagged
+Inquiry
Cat.#:ERBB3-430HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB3 cell lysate
+Inquiry
Cat.#:ERBB3-939HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB3 cell lysate
+Inquiry
Cat.#:ERBB3-1765MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ERBB3 cell lysate
+Inquiry
Cat.#:ERBB3-1415RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ERBB3 cell lysate
+Inquiry
Cat.#:ERBB3-1721RCLTag:N/A
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB3 cell lysate
+Inquiry

Involved Pathway

ERBB3 involved in several pathways and played different roles in them. We selected most pathways ERBB3 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
GRB2; MAP2K2A; PRKCA; PTK2AB; ERBB3; MAP2K4; MAPK8A; NRAS; MYCB; HRASA
Calcium signaling pathway
ADRa1A; ERBB3; EGFRA; PDE1B; NOS1; ORAI2; CALML3; SLC8A1B; CHRM5B; PTGER1
Endocytosis
SMAD2; VPS37D; WASH; RET; CSF1R; SNX1; ITCHA; SH3GL1A; EEA1; SPG21
Proteoglycans in cancer
ITGA2; PLAUR; ITGA5; WNT10B; CAMK2B; PRKCB; FASLG; WNT1; PTPN11; GAB1
MicroRNAs in cancer
MDM4; CDC25A; ROCK1; BRCA1; TNR; SHC4; PDGFB; ATM; FOXP1; MAPK7

Protein Function

ERBB3 has several biochemical functions, for example, ATP binding, growth factor binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERBB3 itself. We selected most functions ERBB3 had, and list some proteins which have the same functions with ERBB3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MYHC4; Adcy4; EPHA7; SMARCAL1; TTLL3; PDXK; BCKDK; DYNC1LI2; STK38L; DYRK1A
Function growth factor binding
Related Protein ACVR2A; LTBP2; A2M; FGFBP2; TEK; NRP2; ERBB3; GHR; IL6ST; NRP1
Function identical protein binding
Related Protein KLHL7; TTC32; LCK; L3MBTL1; TTN; BTK; SNCA; CDC42BPA; DAPK1; TYSND1
Function protein binding
Related Protein PAK2; CDC25A; RPL23A; RAP1A; MB21D2; DAZL; SOX6; RPS15; FLNA; IFIT1
Function protein heterodimerization activity
Related Protein MID2; IKZF1; KCNH1; PPP3CB; SOX8; HOMER1; YWHAE; PIK3R2; BAD; TAS1R3
Function protein homodimerization activity
Related Protein IRAK1; ENG; UGT1A3; CORO1A; CRTAM; S100B; ZFP652; CADM1A; P2RX7; FLNA
Function protein tyrosine kinase activator activity
Related Protein AFAP1L2; ERCC6; GAS6; NRG1; ABI1; CD24; ABI3A; GHRL; Cd24a; ABI1B
Function NOT protein tyrosine kinase activity
Related Protein KLHL8; ERBB3; RYK; TWF1
Function transmembrane signaling receptor activity
Related Protein MARCO; GPR133; SELE; Cd79a, Cd79b; IL4R.1; TNFRSF10C; GHRHRA; PTH1RB; KLRC3; VIPR1B

Interacting Protein

ERBB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERBB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERBB3.
ERBB2

ERBB3 Related Articles

Huang, Z; Choi, BK; et al. The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling. ONCOGENE 34:1105-1115(2015).
Nevoltris, D; Lombard, B; et al. Conformational Nanobodies Reveal Tethered Epidermal Growth Factor Receptor Involved in EGFR/ErbB2 Predimers. ACS NANO 9:1388-1399(2015).