fgfr3
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  • Official Full Name
  • fibroblast growth factor receptor 3
  • Background
  • This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
  • Synonyms
  • FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; fibroblast growth factor receptor 3 variant 4;
Cat.#:FGFR3-207HTag:HIgG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3 Protein, hIgG-His-tagged
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Cat.#:FGFR3-4134HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR3 Protein
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Cat.#:FGFR3-4135HTag:Fc/His
Source (Host):HEK293ESpecies:Human
Product nameRecombinant Human FGFR3 Protein, Fc/His-tagged
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Cat.#:FGFR3-4136HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FGFR3 Protein, GST-tagged
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Cat.#:FGFR3-4137HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR3 Protein, GST-tagged
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Cat.#:FGFR3-5419HTag:his
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 3, His-tagged
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Cat.#:Fgfr3-536MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor Receptor 3, Fc-tagged
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Cat.#:FGFR3-03HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 3, Fc-tagged
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Cat.#:FGFR3-119HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3 Protein, DDK-tagged
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Cat.#:FGFR3-1811HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGFR3 protein, His & T7-tagged
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Cat.#:FGFR3-227HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PLXNA1 Protein, His-tagged
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Cat.#:FGFR3-28835THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR3
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Cat.#:FGFR3-28836THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human FGFR3, Fc-tagged
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Cat.#:FGFR3-315HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3, GST-tagged, Active
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Cat.#:FGFR3-46HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FGFR3 protein, Flag-tagged, Biotinylated
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Cat.#:FGFR3-5003HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 3
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Cat.#:FGFR3-59HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3 (V555M), GST-tagged
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Cat.#:FGFR3-609HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR3, His-tagged, Biotinylated
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Cat.#:FGFR3-610HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR3, Fc-tagged, Biotinylated
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Cat.#:FGFR3-611HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR3, Fc-tagged
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Cat.#:FGFR3-612HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR3, His-tagged
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Cat.#:FGFR3-700HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human FGFR3, Fc Chimera
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Cat.#:FGFR3-751HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3 Protein, Fc-tagged
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Cat.#:FGFR3-752HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3 Protein, His-tagged
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Cat.#:FGFR3-779HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3 Protein, Fc-tagged
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Cat.#:FGFR3-780HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3 Protein, His-tagged
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Cat.#:FGFR3-78HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3, MYC/DDK-tagged
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Cat.#:FGFR3-79HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3, DDK/His-tagged
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Cat.#:FGFR3-80HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3, DDK/His-tagged
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Cat.#:FGFR3-81HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3, DDK/His-tagged
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Cat.#:FGFR3-8320HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human FGFR3
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Cat.#:FGFR3-87HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3, GST-tagged
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Cat.#:FGFR3-88HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3, GST-tagged
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Cat.#:FGFR3-89HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3, GST-tagged
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Cat.#:Fgfr3-1739MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor Receptor 3
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Cat.#:Fgfr3-624MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr3, His tagged
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Cat.#:Fgfr3-706MTag:His/Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr3 protein, His/Fc-tagged
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Cat.#:Fgfr3-836MTag:His/Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr3 Protein, His & Fc-tagged
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Cat.#:FGFR3-1224CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR3 Protein, His-tagged
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Cat.#:FGFR3-204CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR3, Fc-tagged
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Cat.#:FGFR3-7058CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGFR3
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Cat.#:FGFR3-9146ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGFR3
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Cat.#:FGFR3-2596MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FGFR3 cell lysate
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Cat.#:FGFR3-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR3 cell lysate
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Involved Pathway

Fgfr3 involved in several pathways and played different roles in them. We selected most pathways Fgfr3 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgfr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PDGFAA; TP53; CACNB1; FGF13B; MYCB; TGFB2; TGFBR2; PPM1BA; MAPK8IP2; C11orf52
Ras signaling pathway
PAK3; VEGFC; GNB1; GAB2; INS1; PLA2G10; STK4; RAC3; FGFR4; RASAL1
Rap signaling pathway
MRAS; LAT; ITGAL; PRKCB; AKT2; FGF9; NRAS; Kitl; PLCB4; FGF17
Endocytosis
TFRC; VPS26B; CHMP4B; EHD1B; SH3GL3B; FAM21A; PIP5KL1; CHMP4A; RAB11BB; RAB5AB
PIK-Akt signaling pathway
FGF19; HGF; PRKAA2; GNB2; FGF12; PKN3; FGF7; CASP9; EIF4E2; IFNA21
Signaling pathways regulating pluripotency of stem cells
IL6ST; WNT1; PCGF3; ACVR2B; SMAD3; BMP4; STAT3; LIF; SOX2; PIK3CA
Regulation of actin cytoskeleton
FGF9; VAV3; VAV2; MAPK3; SSH2; RRAS2; ABI2B; FGF17; FGF12A; BAIAP2A
Pathways in cancer
FGF20; PIAS2; WNT9B; XIAP; LAMA1; Kitl; FGF5; FLT3; ARNT2; NFKBIA
MicroRNAs in cancer
CCNG1; PDGFA; ABCB1A; RPS6KA5; ZEB2; MMP9; ST14; IRS2; MAPK7; PRKCE
Bladder cancer
SRC; HRAS; DAPK3; TRP53; VEGFA; MAPK1; MMP1A; ERBB2; MMP9; FGFR3
Central carbon metabolism in cancer
GLS2; FLT3; PDHB; HRAS; PIK3CG; PIK3R1; FGFR1; C12orf5; PDK1; SCO2

Protein Function

Fgfr3 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgfr3 itself. We selected most functions Fgfr3 had, and list some proteins which have the same functions with Fgfr3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DAPK2A; ABCC5; CKMT2B; PRKD2; PPIP5K2; MYH8; ITGB1BP3; ORC1L; DNAH14; NMNAT1
Function fibroblast growth factor binding
Related Protein GPC1; FGFR4; HSPA9; CXCL13; Api5; RPS19; THBS1; FIBPA; PTPRZ1; CEP57
Function fibroblast growth factor-activated receptor activity
Related Protein FGFR1B; FGFR1A; FGFR1; FGFR3; FGFR4; FGFR2; FGFRL1
Function protein binding
Related Protein SDC2; HAT1; NIF3L1; U2AF2; RGMA; USP14; SETD6; TMEM25; PUM1; ATOX1
Function protein tyrosine kinase activity
Related Protein ZNF143B; EPHA4B; PTK6B; EPHA7; CSK; DYRK2; ERBB3A; YES1; DYRK3; DYRK4

Interacting Protein

Fgfr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgfr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgfr3.
FGF1; HSP90AB1; saicar; PKM; CTGF; abl-tide; HSPG2; CDC37; NDUFS6; HBZ; CHGB; KRT8; SLC25A6; HNRNPL; ATF3; CTSK

Fgfr3 Related Articles

Correa, D; Somoza, RA; et al. Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. OSTEOARTHRITIS AND CARTILAGE 23:443-453(2015).
Kim, B; Wang, S; et al. Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. ONCOGENE 34:1083-1093(2015).

Fgfr3 Related Gene Family

Cytokines