Fgfr3

Home / Products / Fgfr3

Fgfr3

Official Full Name fibroblast growth factor receptor 3
Background This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
Synonyms FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; fibroblast growth factor receptor 3 variant 4;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293E
    • HEK293T
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • Fc Chimera
    • FC/His
    • Flag
    • GST
    • his
    • HIgG
    • T7
    • His-Avi
    • Myc/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FGFR3-613H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 His-Avi
    Human FGFR3-001H Recombinant Human FGFR3 Protein, Fc-His-tagged HEK293E FC/His
    Human FGFR3-093H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 His-Avi
    Human FGFR3-093HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Mouse Fgfr3-3003M Recombinant Mouse Fgfr3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human FGFR3-6072HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human FGFR3-607H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 His-Avi
    Human FGFR3-607HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human FGFR3-608H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 His-Avi
    Human FGFR3-612HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human FGFR3-03H Recombinant Human Fibroblast Growth Factor Receptor 3, Fc-tagged Insect Cell Fc
    Human FGFR3-119H Recombinant Human FGFR3 Protein, DDK-tagged Insect Cell DDK
    Human FGFR3-1811H Recombinant Human FGFR3 protein, His & T7-tagged E.coli His/T7
    Human FGFR3-207H Recombinant Human FGFR3 Protein, hIgG-His-tagged Insect Cell His/HIgG
    Human FGFR3-227H Recombinant Human PLXNA1 Protein, His-tagged Sf9 Insect Cell GST
    Human FGFR3-28835TH Recombinant Human FGFR3 N/A
    Human FGFR3-28836TH Recombinant Human FGFR3, Fc-tagged Fc
    Human FGFR3-315H Recombinant Human FGFR3, GST-tagged, Active Sf9 Insect Cell GST
    Human FGFR3-4134H Recombinant Human FGFR3 Protein Wheat Germ N/A
    Human FGFR3-4135H Recombinant Human FGFR3 Protein, Fc/His-tagged HEK293E Fc/His
    Human FGFR3-4136H Recombinant Human FGFR3 Protein, GST-tagged Insect Cell GST
    Human FGFR3-4137H Recombinant Human FGFR3 Protein, GST-tagged Wheat Germ GST
    Human FGFR3-46H Recombinant Human FGFR3 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human FGFR3-5003H Recombinant Human Fibroblast Growth Factor Receptor 3 Human N/A
    Human FGFR3-5419H Recombinant Human Fibroblast Growth Factor Receptor 3, His-tagged Insect Cell his
    Human FGFR3-59H Recombinant Human FGFR3 (V555M), GST-tagged Sf9 Insect Cell GST
    Human FGFR3-609H Recombinant Human FGFR3, His-tagged, Biotinylated Human Cell His
    Human FGFR3-610H Recombinant Human FGFR3, Fc-tagged, Biotinylated Human Cell Fc
    Human FGFR3-611H Recombinant Human FGFR3, Fc-tagged Human Cell Fc
    Human FGFR3-612H Recombinant Human FGFR3, His-tagged Human Cell His
    Human FGFR3-700H Recombinant Human FGFR3, Fc Chimera NS0 Fc Chimera
    Human FGFR3-751H Recombinant Human FGFR3 Protein, Fc-tagged HEK293 Fc
    Human FGFR3-752H Recombinant Human FGFR3 Protein, His-tagged HEK293 His
    Human FGFR3-779H Recombinant Human FGFR3 Protein, Fc-tagged HEK293 Fc
    Human FGFR3-780H Recombinant Human FGFR3 Protein, His-tagged HEK293 His
    Human FGFR3-78H Recombinant Human FGFR3, MYC/DDK-tagged HEK293 Myc/DDK
    Human FGFR3-79H Recombinant Human FGFR3, DDK/His-tagged HEK293 DDK/His
    Human FGFR3-80H Recombinant Human FGFR3, DDK/His-tagged HEK293 DDK/His
    Human FGFR3-81H Recombinant Human FGFR3, DDK/His-tagged HEK293 DDK/His
    Human FGFR3-8320H Recombinant Human FGFR3 NS0 N/A
    Human FGFR3-87H Recombinant Human FGFR3, GST-tagged Sf9 Insect Cell GST
    Human FGFR3-88H Recombinant Human FGFR3, GST-tagged Sf9 Insect Cell GST
    Human FGFR3-89H Recombinant Human FGFR3, GST-tagged Sf9 Insect Cell GST
    Mouse Fgfr3-1739M Recombinant Mouse Fibroblast Growth Factor Receptor 3 NSO N/A
    Mouse FGFR3-2596MCL Recombinant Mouse FGFR3 cell lysate Human Cell N/A
    Mouse Fgfr3-536M Recombinant Mouse Fibroblast Growth Factor Receptor 3, Fc-tagged NS0 Fc
    Mouse Fgfr3-624M Recombinant Mouse Fgfr3, His tagged Human Cell His
    Mouse Fgfr3-706M Recombinant Mouse Fgfr3 protein, His/Fc-tagged HEK293 His/Fc
    Mouse Fgfr3-836M Recombinant Mouse Fgfr3 Protein, His & Fc-tagged HEK293 His/Fc
    Cynomolgus Monkey FGFR3-001CCL Recombinant Cynomolgus FGFR3 cell lysate Human Cell N/A
    Cynomolgus Monkey FGFR3-1224C Recombinant Cynomolgus FGFR3 Protein, His-tagged HEK293 His
    Cynomolgus Monkey FGFR3-204C Recombinant Cynomolgus FGFR3, Fc-tagged Human Cell Fc
    Chicken FGFR3-7058C Recombinant Chicken FGFR3 Mammalian Cell His
    Zebrafish FGFR3-9146Z Recombinant Zebrafish FGFR3 Mammalian Cell His

    Fgfr3 involved in several pathways and played different roles in them. We selected most pathways Fgfr3 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgfr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway TRAF2; C11orf52; MAPK14B; FGF13A; CDC42L2; HSP70L; NFATC1; RAP1B; AKT2; HSPA6
    Ras signaling pathway RAP1B; PLA2G12B; RASA1; IGF1R; FGF16; PAK6; Fgf15; CDC42; PLA2G2A; FGF8
    Rap signaling pathway FLT1; KRAS; SRC; FARP2; FGF9; PIK3R2; PIK3R1; KIT; MAP2K3; FGF19
    Endocytosis RAB10; CXCR4A; VPS36; VTA1; CHMP2BA; GBF1; D6WSU116E; ARAP3; CAV1; ACAP2
    PIK-Akt signaling pathway SGK1; G6PC; PDGFRA; EPO; Fasl; IFNB1; IFNA1; IFNA2; PPP2R2B; ITGA8
    Signaling pathways regulating pluripotency of stem cells PCGF2; WNT3; GRB2; ZIC3; LEFTY2; SMAD1; BMPR1B; FZD8; KRAS; WNT16
    Regulation of actin cytoskeleton ITGA3; BDKRB1; PXNA; RAC2; IQGAP2; MAP2K2A; CYFIP1; ITGB1B.2; PFN1; BDKRB2
    Pathways in cancer CDC42; TRAF6; ITGA6; RBX1; KIT; BRAF; ARNT; FZD6; BCR; AGTR1B
    MicroRNAs in cancer PLAU; NOTCH4; HNRNPK; CCND2; PIK3CA; BMPR2; SOCS1; NFKB1; STMN1; RAF1
    Bladder cancer MYC; UPK3A; MAP2K2; HBEGF; TP53; EGF; RASSF1; CDH1; TRP53; E2F3
    Central carbon metabolism in cancer GLS2; HK1; PFKM; PGAM2; MAP2K1; PDGFRA; KRAS; IDH1; PIK3R2; SLC2A1

    Fgfr3 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgfr3 itself. We selected most functions Fgfr3 had, and list some proteins which have the same functions with Fgfr3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ACSBG1; FIGNL2; UBE2D1A; KIF16B; GK; MAP3K1; FAM20B; WARS; DHX33; SLC14A2
    fibroblast growth factor binding FGFR1A; GPC1; RPS2; TGFBR3; FGFR4; HSPA9; GLG1B; FGFBP1; THBS1; FGFR1
    fibroblast growth factor-activated receptor activity FGFR4; FGFR1; FGFR3; FGFR1B; FGFRL1; FGFR2; FGFR1A
    protein binding GPR50; CTGF; MED20; CA1; RNF175; UBE3C; FAIM; KRTAP9-4; HBXIP; SNX3
    protein tyrosine kinase activity EGFRA; KITB; FGFR1OP; FGFR3; ZAP70; FYN; CSK; EPHA2A; AXL; ERBB4

    Fgfr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgfr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgfr3.

    FGF1; HSP90AB1; saicar; PKM; CTGF; abl-tide; HSPG2; CDC37; NDUFS6; HBZ; CHGB; KRT8; SLC25A6; HNRNPL; ATF3; CTSK

    Correa, D; Somoza, RA; et al. Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. OSTEOARTHRITIS AND CARTILAGE 23:443-453(2015).
    Kim, B; Wang, S; et al. Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. ONCOGENE 34:1083-1093(2015).

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy