fgfr3
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  • Official Full Name
  • fibroblast growth factor receptor 3
  • Background
  • This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
  • Synonyms
  • FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; fibroblast growth factor receptor 3 variant 4;
Cat.#:FGFR3-207HTag:HIgG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3 Protein, hIgG-His-tagged
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Cat.#:FGFR3-4134HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR3 Protein
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Cat.#:FGFR3-4135HTag:Fc/His
Source (Host):HEK293ESpecies:Human
Product nameRecombinant Human FGFR3 Protein, Fc/His-tagged
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Cat.#:FGFR3-4136HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FGFR3 Protein, GST-tagged
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Cat.#:FGFR3-4137HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR3 Protein, GST-tagged
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Cat.#:FGFR3-5419HTag:his
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 3, His-tagged
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Cat.#:Fgfr3-536MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor Receptor 3, Fc-tagged
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Cat.#:FGFR3-03HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 3, Fc-tagged
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Cat.#:FGFR3-119HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3 Protein, DDK-tagged
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Cat.#:FGFR3-1811HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGFR3 protein, His & T7-tagged
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Cat.#:FGFR3-227HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PLXNA1 Protein, His-tagged
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Cat.#:FGFR3-28835THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR3
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Cat.#:FGFR3-28836THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human FGFR3, Fc-tagged
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Cat.#:FGFR3-315HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3, GST-tagged, Active
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Cat.#:FGFR3-46HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FGFR3 protein, Flag-tagged, Biotinylated
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Cat.#:FGFR3-5003HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 3
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Cat.#:FGFR3-59HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3 (V555M), GST-tagged
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Cat.#:FGFR3-609HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR3, His-tagged, Biotinylated
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Cat.#:FGFR3-610HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR3, Fc-tagged, Biotinylated
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Cat.#:FGFR3-611HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR3, Fc-tagged
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Cat.#:FGFR3-612HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR3, His-tagged
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Cat.#:FGFR3-700HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human FGFR3, Fc Chimera
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Cat.#:FGFR3-751HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3 Protein, Fc-tagged
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Cat.#:FGFR3-752HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3 Protein, His-tagged
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Cat.#:FGFR3-779HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3 Protein, Fc-tagged
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Cat.#:FGFR3-780HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3 Protein, His-tagged
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Cat.#:FGFR3-78HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3, MYC/DDK-tagged
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Cat.#:FGFR3-79HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3, DDK/His-tagged
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Cat.#:FGFR3-80HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3, DDK/His-tagged
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Cat.#:FGFR3-81HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR3, DDK/His-tagged
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Cat.#:FGFR3-8320HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human FGFR3
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Cat.#:FGFR3-87HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3, GST-tagged
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Cat.#:FGFR3-88HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3, GST-tagged
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Cat.#:FGFR3-89HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR3, GST-tagged
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Cat.#:Fgfr3-1739MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor Receptor 3
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Cat.#:Fgfr3-624MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr3, His tagged
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Cat.#:Fgfr3-706MTag:His/Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr3 protein, His/Fc-tagged
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Cat.#:Fgfr3-836MTag:His/Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr3 Protein, His & Fc-tagged
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Cat.#:FGFR3-1224CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR3 Protein, His-tagged
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Cat.#:FGFR3-204CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR3, Fc-tagged
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Cat.#:FGFR3-7058CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGFR3
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Cat.#:FGFR3-9146ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGFR3
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Cat.#:FGFR3-2596MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FGFR3 cell lysate
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Cat.#:FGFR3-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR3 cell lysate
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Involved Pathway

Fgfr3 involved in several pathways and played different roles in them. We selected most pathways Fgfr3 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgfr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNB4A; RPS6KA3B; FOS; HSPA1L; FGF21; FLNB; MAPK13; GRB2A; MAPK12; GNA12
Ras signaling pathway
CALML5; ETS1; MRAS; PAK6; PIK3R3; PLA1A; FOXO4; GNG12; RELA; RASSF5
Rap signaling pathway
KIT; FGF1; PRKCG; MAP2K6; GNAI2; ID1; CALM2; TEK; RAF1; THBS1
Endocytosis
ARF3A; CHMP4A; RHOAA; CYTH1B; AGAP1; EPS15; RAB11B; CHMP6B; ARPC5LA; CLINT1A
PIK-Akt signaling pathway
IL3; FGF16; Reln; ITGB3; CCND3; CREB3L2; PIK3R3; AKT1; CCND1; GNG7
Signaling pathways regulating pluripotency of stem cells
NODAL; HNF1A; POU5F1; FZD2; BMP4; MAPK1; IGF1R; FGFR2; NRAS; DLX5
Regulation of actin cytoskeleton
FGF11A; ACTN2B; PAK2; GSNB; ITGA5; GNA13A; WASL; PDGFA; SRC; ITGB1A
Pathways in cancer
GNAI1; CSF1R; HGF; RET; GNG4; GNB1; GNG7; FGF19; NFKBIA; LPAR6
MicroRNAs in cancer
Pdgfa&Pdgfb; APC2; HMOX1; KRAS; DNMT1; RPS6KA5; BMPR2; ST14; STMN1; GLS2
Bladder cancer
FGFR3; MYC; CDK4; MAP2K2; MDM2; MAP2K1; RASSF1; ARAF; TYMP; SRC
Central carbon metabolism in cancer
FGFR1; MTOR; PGAM1; SLC7A5; PFKP; HK1; PIK3CA; GLS; PIK3R2; AKT1

Protein Function

Fgfr3 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgfr3 itself. We selected most functions Fgfr3 had, and list some proteins which have the same functions with Fgfr3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein Abca2; LIMK1; TP53; NME2; KIF25; BMPR1BB; NLRP1; PKM; ABCD4; TWF2
Function fibroblast growth factor binding
Related Protein GPC1; THBS1; PTPRZ1; FGFR4; CEP57; FGFR1; TGFBR3; FGFR1A; GLG1; HSPA9
Function fibroblast growth factor-activated receptor activity
Related Protein FGFR4; FGFR1; FGFR2; FGFR1B; FGFR1A; FGFR3; FGFRL1
Function protein binding
Related Protein BLOC1S3; FRMD6; MIER1; FAM59A; GOSR2; RING1; C11orf57; RAB6A; MIEF1; APP
Function protein tyrosine kinase activity
Related Protein INSRA; FGFR1; MATK; DYRK1B; TEK; TESK2; FGFR4; RET; MUSK; PTK7A

Interacting Protein

Fgfr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgfr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgfr3.
FGF1; HSP90AB1; saicar; PKM; CTGF; abl-tide; HSPG2; CDC37; NDUFS6; HBZ; CHGB; KRT8; SLC25A6; HNRNPL; ATF3; CTSK

Fgfr3 Related Articles

Correa, D; Somoza, RA; et al. Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. OSTEOARTHRITIS AND CARTILAGE 23:443-453(2015).
Kim, B; Wang, S; et al. Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. ONCOGENE 34:1083-1093(2015).

Fgfr3 Related Gene Family

Cytokines