Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated

• Cat.No.: FGFR3-6072HB
• Product Overview: Biotinylated Recombinant Human FGFR3 (IIIb) Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Glu23-Gly377.

Specification

• Description: Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22μm filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 41.4 KDa. Due to glycosylation, the protein migrates to 65-75 KDa based on Bis-Tris PAGE result.
• Protein length: Glu23-Gly377
• Endotoxin: Less than 1 EU per μg by the LAL method.
• Purity: >95% as determined by Tris-Bis PAGE; >95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: FGFR3
• Official Symbol: FGFR3
• Synonyms: CD333; CEK; EC 2.7.10; FGF R3; FGFR3; fibroblast growth factor receptor 3; HSFGFR3EX; JTK4; JTK4thanatophoric dwarfism
• Gene ID: 2261
• mRNA Refseq: NM_000142.5
• Protein Refseq: NP_000133.1
• MIM: 134934
• UniProt ID: P22607

Reviews

01/13/2020

Researchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.

03/26/2018

Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.

08/29/2017

Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.

Q&As

How does FGFR3 testing assist in personalized medicine approaches?

FGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.

Is FGFR3 testing routinely conducted in cancer diagnosis?

FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.

Can FGFR3 be a prognostic marker in cancer?

Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.

Are there targeted therapies based on FGFR3 in cancer treatment?

Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.

How is FGFR3 targeted in cancer therapy?

FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.