Active Recombinant Human FGFR3 Homodimer Protein, His&Avi tagged

• Cat.No.: FGFR3-40H
• Product Overview: FGFR3 dimer protein contains a FGFR3 extracellular domain (UniProt# P22607) fused with a proprietary cis-dimer motif followed by a tandem His-Avi tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 23-375 aa
• Description: Human fibroblast growth factor receptor 3 (FGFR3) is a cell surface receptor belonging to the immunoglobulin superfamily and a transmembrane receptor tyrosine kinase (RTK) that belongs to the FGFR family. FGFR3 is also known as ACH, cluster of differentiation 333 (CD333), CEK2, HSFGFR3EX, and JTK4. FGFR3 contains an extracellular domain with three immunoglobulin-like (Ig-like) subdomains (D1, D2 and D3), followed by a transmembrane, and an intracellular domain. Dimerization of FGFRs is necessary for activation and they can homodimerize and heterodimerize in both the presence and absence of ligand. FGFRs bind fibroblast growth factors (FGFs) leading to phosphorylation and triggering signaling cascades. FGFR3 is involved in diseases including achondroplasia, hypochondroplasia, and bladder cancer. Therefore, a recombinant protein mimicking the FGFR3 dimer conformation can be critical for cancer therapeutic discovery.
• Molecular Mass: 96 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for FGFR3-specific antibody binding assays and BLI for fibroblast growth factor 1 (FGF-1) ligand protein binding assays. Suggested Applications: SPR for FGFR3-specific antibody and FGF-1 protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens (human) ]
• Official Symbol: FGFR3
• Synonyms: FGFR3; fibroblast growth factor receptor 3; ACH, achondroplasia, thanatophoric dwarfism; CD333; CEK2; JTK4; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; ACH; HSFGFR3EX
• Gene ID: 2261
• mRNA Refseq: NM_000142
• Protein Refseq: NP_000133
• MIM: 134934
• UniProt ID: P22607