Recombinant Human FGFR3 protein, Flag-tagged, Biotinylated
Cat.No. : | FGFR3-46H |
Product Overview : | Recombinant Human FGFR3, cytoplasmic domain [436-806(end) amino acids of accession number NP_000133.1] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated. |
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Source : | Insect cell |
Species : | Human |
Tag : | Flag |
Form : | 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5 |
Molecular Mass : | 52 kDa |
Purity : | >97% as determined by SDS-PAGE and CBB staining |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Protein length : | 436-806 |
Gene Name : | FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ] |
Official Symbol : | FGFR3 |
Synonyms : | FGFR3; fibroblast growth factor receptor 3; CD333; CEK2; JTK4; FGFR-3; tyrosine kinase JTK4; ACH; HSFGFR3EX; |
Gene ID : | 2261 |
mRNA Refseq : | NM_000142 |
Protein Refseq : | NP_000133 |
MIM : | 134934 |
UniProt ID : | P22607 |
Chromosome Location : | 4p16.3 |
Pathway : | Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; FGFR ligand binding and activation, organism-specific biosystem; |
Function : | ATP binding; fibroblast growth factor binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; nucleotide binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewResearchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.
Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.
Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.
Q&As (5)
Ask a questionFGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.
FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.
Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.
Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.
FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.
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