Recombinant Human FGFR3 protein, Flag-tagged, Biotinylated

Cat.No. : FGFR3-46H
Product Overview : Recombinant Human FGFR3, cytoplasmic domain [436-806(end) amino acids of accession number NP_000133.1] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated.
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Source : Insect cell
Species : Human
Tag : Flag
Form : 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
Molecular Mass : 52 kDa
Purity : >97% as determined by SDS-PAGE and CBB staining
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ]
Official Symbol : FGFR3
Synonyms : FGFR3; fibroblast growth factor receptor 3; CD333; CEK2; JTK4; FGFR-3; tyrosine kinase JTK4; ACH; HSFGFR3EX;
Gene ID : 2261
mRNA Refseq : NM_000142
Protein Refseq : NP_000133
MIM : 134934
UniProt ID : P22607
Chromosome Location : 4p16.3
Pathway : Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; FGFR ligand binding and activation, organism-specific biosystem;
Function : ATP binding; fibroblast growth factor binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; nucleotide binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Reviews
01/13/2020

    Researchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.

    03/26/2018

      Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.

      08/29/2017

        Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.

        Q&As (5)

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        How does FGFR3 testing assist in personalized medicine approaches? 12/13/2022

        FGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.

        Is FGFR3 testing routinely conducted in cancer diagnosis? 06/25/2022

        FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.

        Can FGFR3 be a prognostic marker in cancer? 12/01/2016

        Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.

        Are there targeted therapies based on FGFR3 in cancer treatment? 07/23/2016

        Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.

        How is FGFR3 targeted in cancer therapy? 03/13/2016

        FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.

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