Recombinant Human FGFR3 Protein, hIgG-His-tagged
Cat.No. : | FGFR3-207H |
Product Overview : | Recombinant Human FGFR3(23-375aa) fused with hIgG-His tag at C-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | FGFR3, also known as fibroblast growth factor receptor 3 isoform 1, is a member of the fibroblast growth factor receptor family. It is a family of polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing. Its activation results in autophosphorylation of multiple tyrosine residues within the intracellular domain. It plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. It frequently involved in human developmental disorders and is associated with several cancers, including multiple myeloma (MM). |
Source : | Insect cells |
Species : | Human |
Tag : | hIgG-His |
Form : | Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Molecular Mass : | 65.1kDa (592aa) 70-100kDa (SDS-PAGE under reducing conditions) |
Protein length : | 23-375aa |
AA Sequence : | ESLGTEQRVV GRAAEVPGPE PGQQEQLVFG SGDAVELSCP PPGGGPMGPT VWVKDGTGLV PSERVLVGPQ RLQVLNASHE DSGAYSCRQR LTQRVLCHFS VRVTDAPSSG DDEDGEDEAE DTGVDTGAPY WTRPERMDKK LLAVPAANTV RFRCPAAGNP TPSISWLKNG REFRGEHRIG GIKLRHQQWS LVMESVVPSD RGNYTCVVEN KFGSIRQTYT LDVLERSPHR PILQAGLPAN QTAVLGSDVE FHCKVYSDAQ PHIQWLKHVE VNGSKVGPDG TPYVTVLKTA GANTTDKELE VLSLHNVTFE DAGEYTCLAG NSIGFSHHSA WLVVLPAEEE LVEADEAGSV YAGLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH |
Purity : | > 95% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1mg/ml (determined by Absorbance at 280nm) |
Gene Name : | FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ] |
Official Symbol : | FGFR3 |
Synonyms : | FGFR3; fibroblast growth factor receptor 3; ACH, achondroplasia, thanatophoric dwarfism; CD333; CEK2; JTK4; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; ACH; HSFGFR3EX; |
Gene ID : | 2261 |
mRNA Refseq : | NM_000142 |
Protein Refseq : | NP_000133 |
MIM : | 134934 |
UniProt ID : | P22607 |
Products Types
◆ Recombinant Protein | ||
FGFR3-001H | Recombinant Human FGFR3 Protein, Fc-His-tagged | +Inquiry |
FGFR3-93H | Recombinant Human FGFR3 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
Fgfr3-3003M | Recombinant Mouse Fgfr3 Protein, Myc/DDK-tagged | +Inquiry |
FGFR3-5419H | Recombinant Human Fibroblast Growth Factor Receptor 3, His-tagged | +Inquiry |
Fgfr3-10554M | Recombinant Mouse Fgfr3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FGFR3-001CCL | Recombinant Cynomolgus FGFR3 cell lysate | +Inquiry |
FGFR3-2596MCL | Recombinant Mouse FGFR3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.
FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.
Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.
Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.
FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.
Customer Reviews (3)
Write a reviewResearchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.
Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.
Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.
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