Active Recombinant Mouse Fgfr3 Protein, His & Fc-tagged

• Cat.No.: Fgfr3-836M
• Product Overview: Recombinant extracellular domain (Met 1-Tyr 367) of mouse FGFR3 (NP_032036.2) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Fc&His
• Protein Length: 1-367 a.a.
• Predicted N Terminal: Glu 21
• Form: Lyophilized from sterile PBS, pH 7.4, 5%~8% trehalose and mannitol.
• Bio-activity: Measured by its ability to bind mouse aFGF in a functional ELISA.
• Molecular Mass: The recombinant mouse FGFR3/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 595 amino acids and has a predicted molecular mass of 66 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm FGFR3/Fc monomer is approximately 100-110 kDa due to glycosylation.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >92 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
• Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: Fgfr3 fibroblast growth factor receptor 3 [ Mus musculus ]
• Official Symbol: Fgfr3
• Synonyms: FGFR3; fibroblast growth factor receptor 3; heparin-binding growth factor receptor; FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3
• Gene ID: 14184
• mRNA Refseq: NM_001163215
• Protein Refseq: NP_001156687
• Pathway: Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; ESC Pluripotency Pathways, organism-specific biosystem; Endochondral Ossification, organism-specific bio
• Function: ATP binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; fibroblast growth factor-activated receptor activity; kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity; receptor act