il1rap
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  • Official Full Name
  • interleukin 1 receptor accessory protein
  • Background
  • Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
  • Synonyms
  • IL1RAP; interleukin 1 receptor accessory protein; IL1R3; C3orf13; IL-1RAcP; IL-1R3; interleukin-1 receptor 3; interleukin-1 receptor accessory protein beta; OTTHUMP00000209487; OTTHUMP00000209488; OTTHUMP00000209489; OTTHUMP00000209490; OTTHUMP00000209491; OTTHUMP00000209492; IL-1 receptor accessory protein; OTTHUMP00000209493; FLJ37788; interleukin-1 receptor accessory protein; OTTHUMP00000209485; OTTHUMP00000209486; IL-1R-3
Cat.#:IL1RAP-175HATag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP protein, Fc-His-tagged, APC labeled
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Cat.#:IL1RAP-175HPTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP protein, Fc-His-tagged, R-PE labeled
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Cat.#:Il1rap-443MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL1RAP Protein, His-tagged
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Cat.#:Il1rap-444MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL1RAP Protein, Fc-tagged
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Cat.#:IL1RAP-627HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP protein, Fc-tagged, APC labeled
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Cat.#:IL1RAP-627HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP protein, Fc-tagged, R-PE labeled
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Cat.#:IL1RAP-1820HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP Protein, MYC/DDK-tagged
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Cat.#:IL1RAP-14176HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1RAP, His-tagged
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Cat.#:IL1RAP-175HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP, Fc-His tagged
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Cat.#:IL1RAP-215HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP Protein, His-tagged
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Cat.#:IL1RAP-2256HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP, His tagged
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Cat.#:IL1RAP-627HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP, Fc-tagged
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Cat.#:IL1RAP-628HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human IL1RAP, Fc-tagged, Biotinylated
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Cat.#:Il1rap-1576MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1rap protein, His & T7-tagged
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Cat.#:IL1RAP-2241RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL1RAP Protein, His-tagged
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Cat.#:IL1RAP-1638HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Interleukin 1 Receptor Accessory Protein-Like 1
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Cat.#:IL1RAP-2730HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RAP cell lysate
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Involved Pathway

IL1RAP involved in several pathways and played different roles in them. We selected most pathways IL1RAP participated on our site, such as Cytokine-cytokine receptor interaction, Apoptosis, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1RAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
GH2; IFNAR1; IL5RA; MET; CXCL2; IL21R; BMP7A; GM2506; CSF1R; Ccl27a
Apoptosis
IL1RAP; PIK3CB; CASP6L1; DSG1; CAPN1A; HIST1H1E; XIAP; BMX; YWHAQ; BIRC7
Inflammatory mediator regulation of TRP channels
SRC; CAMK2D; PLCB3; ITPR3; PIK3R2; PLA2G4C; PIK3CG; TRPV3; PRKCD; GNAQ

Protein Function

IL1RAP has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-1 receptor binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1RAP itself. We selected most functions IL1RAP had, and list some proteins which have the same functions with IL1RAP. You can find most of the proteins on our site.
Function
Related Protein
Function interleukin-1 receptor activity
Related Protein IL1RAPL1A; IL1RL1; IL18R1; IL1RAPL2; IL1RAP; IL1R2; IL1RL2; IL1R1
Function interleukin-1 receptor binding
Related Protein TRIP6; IL37; IL36A; IL1A; Il1f6; IL36RN; IL1B; IL1F10; IL1RN; IL36G
Function signal transducer activity
Related Protein GULP1; PLCXD3; BCAR1; PROKR1A; PARAPINOPSINB; EDNRAA; TAAR12J; OLFR510; OLFR181; TMTOPS3A

Interacting Protein

IL1RAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1RAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1RAP.
IL1B; IL1R2; IL1R1; SMAD2; TICAM2; PRPF40A; MC4R; PRKCI; KPNA1; CCNI

IL1RAP Related Articles

Askmyr, M; Agerstam, H; et al. Selective killing of candidate AML stem cells by antibody targeting of IL1RAP. BLOOD 121:3709-3713(2013).
Jaras, M; Johnels, P; et al. Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:16280-16285(2010).
Jaras, M; Johnels, P; et al. ISOLATION AND KILLING OF CANDIDATE CML STEM CELLS BY ANTIBODY TARGETING OF IL1RAP. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 95:242-242(2010).

IL1RAP Related Gene Family

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