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Recombinant Mouse IL1RAP Protein, His-tagged

Cat.No. : Il1rap-443M
Product Overview : Recombinant Mouse Il1rap (NP_598864.1) (Met1-Lys350) was expressed with a polyhistidine tag at the C-terminus.
  • Specification
  • Gene Information
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Description : Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by ass centigradeiating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.
Source : HEK293
Species : Mouse
Tag : His
Predicted N Terminal : Ser 21
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant mouse Il1rap consists of 341 amino acids and predicts a molecular mass of 39.7 kDa.
Protein length : Met1-Lys350
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Il1rap interleukin 1 receptor accessory protein [ Mus musculus ]
Official Symbol : Il1rap
Synonyms : IL1RAP; interleukin 1 receptor accessory protein; interleukin-1 receptor accessory protein; IL-1 receptor accessory protein; AI255955; AV239853; IL-1RAcP; 6430709H04Rik;
Gene ID : 16180
mRNA Refseq : NM_001159317
Protein Refseq : NP_001152789

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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