- Human(26)
- Mouse(4)
- Rhesus Macaque(1)
Recombinant Mouse IL1RAP Protein, Fc-tagged
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Cat.No. : | Il1rap-444M Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Mouse Il1rap (NP_598864.1) (Met1-Lys350) was expressed with the Fc region of human IgG1 at the C-terminus. |
Description : | Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by ass centigradeiating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor. |
Source : | HEK293 |
Species : | Mouse |
Tag : | Fc |
Predicted N Terminal : | Ser 21 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The recombinant mouse Il1rap consists of 568 amino acids and predicts a molecular mass of 65 kDa. |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE. |
Storage : | Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
Gene Name : | Il1rap interleukin 1 receptor accessory protein [ Mus musculus ] |
Official Symbol : | Il1rap |
Synonyms : | IL1RAP; interleukin 1 receptor accessory protein; interleukin-1 receptor accessory protein; IL-1 receptor accessory protein; AI255955; AV239853; IL-1RAcP; 6430709H04Rik; |
Gene ID : | 16180 |
mRNA Refseq : | NM_001159317 |
Protein Refseq : | NP_001152789 |
◆ Recombinant Protein
IL1RAP-1820H | Recombinant Human IL1RAP Protein, MYC/DDK-tagged | +Inquiry |
Il1rap-3508M | Recombinant Mouse Il1rap Protein, Myc/DDK-tagged | +Inquiry |
IL1RAP-356H | Recombinant Human IL1RAP Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Il1rap-443M | Recombinant Mouse IL1RAP Protein, His-tagged | +Inquiry |
IL1RAP-093H | Recombinant Human IL1RAP protein, His-Avi-tagged | +Inquiry |
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◆ Lysates
IL1RAP-2730HCL | Recombinant Human IL1RAP cell lysate | +Inquiry |
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IL10 IL10RA IL10RB IL11 IL11RA Il11ra1 IL12 IL12A IL12B IL12RB1 IL13 IL13RA1 IL13RA2 IL15 IL15RA IL16 IL17A IL17B Il17c IL17D Il17f IL17RA IL17RD IL18 IL18BP IL18R1 IL18RAP Il19 Il1a Il1b IL1F10 IL1R1 Il1r2 IL1RAP IL1RAPL1 IL1RAPL2 IL1RL1 IL1RL2 Il1rn IL2 Il20 IL20RA IL21 IL21R IL22 IL22BP IL22RA1 IL22RA2 IL23A IL24 Il25 IL27 IL27RA IL28A Il28b IL29 IL2RA IL2RB Il2rg IL3 IL31 IL32 Il33 Il34 IL3RA IL4 IL4R Il4ra Il5 IL5RA Il6 IL6R Il6ra IL6ST Il7 IL7R IL8 IL9 IL36A Il12rb2 IL17RB IL23R IL26 IL31RA IL36B IL36G IL36RN IL37 IL9R IL17RC IL17RE IL28RA IL4I1 IL20RB IL17REL Il11ra2 IL27b IL7RA Il23a&Il12b
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