Active Recombinant Human IL1RAP, Fc-tagged, Biotinylated

Cat.No. : IL1RAP-628H
Product Overview : The recombinant human IL1RAP ECD is expressed as a 585 amino acid protein consisting of Ser21 - -Thr367 region of IL1RAP (UniProt accession #Q9NPH3) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
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Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds human IL1 as well as IL1R1 and IL1R2, and blocks IL1-dependent signaling activity with a typical ED50 of 0.5 - 2.5 μg/ml.
Molecular Mass : Calculated molecular mass (kDa): 66.5; Estimated by SDS-PAGE under reducing condition (kDa): 75-80 (probably due to glycosylation).
AA Sequence : SERCDDWGLDTMRQIQVFEDEPARI KCPLFEHFLKFNYSTAHSAGLTLIW YWTRQDRDLEEPINFRLPENRISK EKDVLWFRPTLLNDTGNYTCMLRNT TYCSKVAFPLEVVQKDSCFNSPMKL PVHKLYIEYGIQRITCPNVDGYFP SSVKPTITWYMGCYKIQNFNNVIPE GMNLSFLIALISNNGNYTCVVTYPE NGRTFHLTRTLTVKVVGSPKNAVP PVIHSPNDHVVYEKEPGEELLIPCT VYFSFLMDSRNEVWWTIDGKKPDDI TIDVTINESISHSRTEDETRTQIL SIKKVTSEDLKRSYVCHARSAKGEV AKAAKVKQKVPAPRYTVELACGFGA TSTTENLYFQGSTGTHTCPPCPAP ELLGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVL TVLHQDWLNGKEYKCKVSNKALPAP IEKTISKAKGQPREPQVYTLPPSRE EMTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFF LYSKLTVDKSRWQQGNVFSCSVMHE ALHNHYTQKSLSLSPGK
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : IL1RAP interleukin 1 receptor accessory protein [ Homo sapiens ]
Official Symbol : IL1RAP
Synonyms : IL1RAP; interleukin 1 receptor accessory protein; interleukin-1 receptor accessory protein; C3orf13; IL 1RAcP; IL1R3; IL-1R3; interleukin-1 receptor 3; IL-1 receptor accessory protein; interleukin-1 receptor accessory protein beta; IL-1RAcP; FLJ37788;
Gene ID : 3556
mRNA Refseq : NM_001167928
Protein Refseq : NP_001161400
MIM : 602626
UniProt ID : Q9NPH3
Chromosome Location : 3q28
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL-1 Signaling Pathway, organism-specific biosystem; Immune System, organism-specific biosystem;
Function : interleukin-1 receptor activity; receptor activity; signal transducer activity; transmembrane signaling receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How can single-cell RNA sequencing and proteomics uncover IL1RAP's interactions with immune receptors within complex networks? 02/11/2021

Single-cell RNA sequencing and proteomics unveil IL1RAP's interactions in networks.

Can genome-wide mapping and functional assays reveal the epigenetic regulation and context-specific expression of the IL1RAP gene? 02/19/2019

Genome mapping and assays unveil IL1RAP's epigenetic control.

How can we unravel IL1RAP's varied distribution across cell types and tissues, clarifying its functional versatility? 11/05/2017

Innovative methods clarify IL1RAP's distribution diversity, revealing its functional adaptability.

How do advanced imaging and genetic knockout models shed light on IL1RAP's role in immune cell dynamics and functions? 05/01/2017

Advanced imaging and genetic models illuminate IL1RAP's immune role.

What insights do computational simulations and in vitro experiments provide into IL1RAP's interaction kinetics and stability? 11/04/2016

Simulations and experiments reveal IL1RAP's interaction details.

Do engineered cellular models clarify IL1RAP's mechanisms in inflammasome activation and cytokine release? 08/20/2016

Engineered cell models shed light on IL1RAP's role in inflammation.

Can structural biology techniques elucidate IL1RAP's conformational changes and ligand interactions in inflammation? 07/25/2016

Structural techniques provide insights into IL1RAP's ligand interactions.

What strategies unveil the influence of post-translational modifications on IL1RAP's localization and signaling pathways? 07/19/2016

Strategies uncover post-translational effects on IL1RAP's signaling.

How do organ-on-chip technologies mimic tissue microenvironments to explore IL1RAP's impact on signaling pathways? 07/14/2016

Organ-on-chip tech explores IL1RAP's impact on pathways.

What innovative methods decode IL1RAP isoforms in different cells, revealing their impact on cellular responses? 06/07/2016

Novel techniques decode IL1RAP isoforms, exposing their influence on cell responses.

Customer Reviews (3)

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Reviews
05/25/2021

    High solubility.

    07/22/2019

      Good for intracellular staining.

      05/13/2018

        Effective in apoptosis assays.

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