Active Recombinant Human IL1RAP, Fc-tagged, Biotinylated
Cat.No. : | IL1RAP-628H |
Product Overview : | The recombinant human IL1RAP ECD is expressed as a 585 amino acid protein consisting of Ser21 - -Thr367 region of IL1RAP (UniProt accession #Q9NPH3) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions. |
- Specification
- Gene Information
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Source : | Human cells |
Species : | Human |
Tag : | Fc |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). |
Bio-activity : | Binds human IL1 as well as IL1R1 and IL1R2, and blocks IL1-dependent signaling activity with a typical ED50 of 0.5 - 2.5 μg/ml. |
Molecular Mass : | Calculated molecular mass (kDa): 66.5; Estimated by SDS-PAGE under reducing condition (kDa): 75-80 (probably due to glycosylation). |
AA Sequence : | SERCDDWGLDTMRQIQVFEDEPARI KCPLFEHFLKFNYSTAHSAGLTLIW YWTRQDRDLEEPINFRLPENRISK EKDVLWFRPTLLNDTGNYTCMLRNT TYCSKVAFPLEVVQKDSCFNSPMKL PVHKLYIEYGIQRITCPNVDGYFP SSVKPTITWYMGCYKIQNFNNVIPE GMNLSFLIALISNNGNYTCVVTYPE NGRTFHLTRTLTVKVVGSPKNAVP PVIHSPNDHVVYEKEPGEELLIPCT VYFSFLMDSRNEVWWTIDGKKPDDI TIDVTINESISHSRTEDETRTQIL SIKKVTSEDLKRSYVCHARSAKGEV AKAAKVKQKVPAPRYTVELACGFGA TSTTENLYFQGSTGTHTCPPCPAP ELLGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVL TVLHQDWLNGKEYKCKVSNKALPAP IEKTISKAKGQPREPQVYTLPPSRE EMTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFF LYSKLTVDKSRWQQGNVFSCSVMHE ALHNHYTQKSLSLSPGK |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the lal>0.1> |
Purity : | >95% judged by SDS-PAGE under reducing condition |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Gene Name : | IL1RAP interleukin 1 receptor accessory protein [ Homo sapiens ] |
Official Symbol : | IL1RAP |
Synonyms : | IL1RAP; interleukin 1 receptor accessory protein; interleukin-1 receptor accessory protein; C3orf13; IL 1RAcP; IL1R3; IL-1R3; interleukin-1 receptor 3; IL-1 receptor accessory protein; interleukin-1 receptor accessory protein beta; IL-1RAcP; FLJ37788; |
Gene ID : | 3556 |
mRNA Refseq : | NM_001167928 |
Protein Refseq : | NP_001161400 |
MIM : | 602626 |
UniProt ID : | Q9NPH3 |
Chromosome Location : | 3q28 |
Pathway : | Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL-1 Signaling Pathway, organism-specific biosystem; Immune System, organism-specific biosystem; |
Function : | interleukin-1 receptor activity; receptor activity; signal transducer activity; transmembrane signaling receptor activity; |
Products Types
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IL1RAP-356H | Recombinant Human IL1RAP Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
IL1RAP-305H | Recombinant Human IL1RAP Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
IL1RAP-2730HCL | Recombinant Human IL1RAP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionSingle-cell RNA sequencing and proteomics unveil IL1RAP's interactions in networks.
Genome mapping and assays unveil IL1RAP's epigenetic control.
Innovative methods clarify IL1RAP's distribution diversity, revealing its functional adaptability.
Advanced imaging and genetic models illuminate IL1RAP's immune role.
Simulations and experiments reveal IL1RAP's interaction details.
Engineered cell models shed light on IL1RAP's role in inflammation.
Structural techniques provide insights into IL1RAP's ligand interactions.
Strategies uncover post-translational effects on IL1RAP's signaling.
Organ-on-chip tech explores IL1RAP's impact on pathways.
Novel techniques decode IL1RAP isoforms, exposing their influence on cell responses.
Customer Reviews (3)
Write a reviewHigh solubility.
Good for intracellular staining.
Effective in apoptosis assays.
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