Recombinant Human Interleukin 1 Receptor Accessory Protein-Like 1

• Cat.No.: IL1RAP-1638H

Specification

• Cat. No.: IL1RAP-1638H
• Description: IL-1R accessory protein (IL-1RAcP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL-1-dependent activation of transcription factors and gene expression. IL-1R AcP represents a novel target for blocking IL-1 function in human disease.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-1 R3 is Mr 67.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-75 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
• Tag: Non

Gene Information

• Gene Name: L1RAP interleukin 1 receptor accessory protein [ Homo sapiens ]
• Synonyms: IL1RAP; interleukin 1 receptor accessory protein; IL1R3; C3orf13; FLJ37788; IL-1RAcP; OTTHUMP00000209486; OTTHUMP00000209487; OTTHUMP00000209489; OTTHUMP00000209492; interleukin-1 receptor accessory protein beta; IL-1 receptor accessory protein; IL-1RAcP
• Gene ID: 3556
• mRNA Refseq: NM_002182
• Protein Refseq: NP_002173
• MIM: 602626
• UniProt ID: Q9NPH3
• Chromosome Location: 3q28
• Pathway: Apoptosis; Cytokine-cytokine receptor interaction
• Function: interleukin-1 receptor activity; protein binding; transmembrane receptor activity

Reviews

05/25/2021

High solubility.

07/22/2019

Good for intracellular staining.

05/13/2018

Effective in apoptosis assays.

Q&As

How can single-cell RNA sequencing and proteomics uncover IL1RAP's interactions with immune receptors within complex networks?

Single-cell RNA sequencing and proteomics unveil IL1RAP's interactions in networks.

Can genome-wide mapping and functional assays reveal the epigenetic regulation and context-specific expression of the IL1RAP gene?

Genome mapping and assays unveil IL1RAP's epigenetic control.

How can we unravel IL1RAP's varied distribution across cell types and tissues, clarifying its functional versatility?

Innovative methods clarify IL1RAP's distribution diversity, revealing its functional adaptability.

How do advanced imaging and genetic knockout models shed light on IL1RAP's role in immune cell dynamics and functions?

Advanced imaging and genetic models illuminate IL1RAP's immune role.

What insights do computational simulations and in vitro experiments provide into IL1RAP's interaction kinetics and stability?

Simulations and experiments reveal IL1RAP's interaction details.

Do engineered cellular models clarify IL1RAP's mechanisms in inflammasome activation and cytokine release?

Engineered cell models shed light on IL1RAP's role in inflammation.

Can structural biology techniques elucidate IL1RAP's conformational changes and ligand interactions in inflammation?

Structural techniques provide insights into IL1RAP's ligand interactions.

What strategies unveil the influence of post-translational modifications on IL1RAP's localization and signaling pathways?

Strategies uncover post-translational effects on IL1RAP's signaling.

How do organ-on-chip technologies mimic tissue microenvironments to explore IL1RAP's impact on signaling pathways?

Organ-on-chip tech explores IL1RAP's impact on pathways.

What innovative methods decode IL1RAP isoforms in different cells, revealing their impact on cellular responses?

Novel techniques decode IL1RAP isoforms, exposing their influence on cell responses.