LOX

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LOX

Official Full Name lysyl oxidase
Background The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms LOX; lysyl oxidase; protein-lysine 6-oxidase; ras excision protein; ras recision gene (rrg); TSC-160; AI893619
    • Species :
    • Aerococcuss viridans
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • Aerococcuss viridans
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • GST
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-2318 5-Lipoxygenase Inhibitor Screening Kit (Fluorometric) N/A
    Rat LOX-628R Recombinant Rat LOX Protein (163-411 aa), His-tagged E.coli His
    Human LOX-157H Recombinant Human LOX protein, T7/His-tagged E.coli T7/His
    Human LOX-189H Recombinant Human LOX protein, GST-tagged Insect Cell GST
    Human LOX-4677HCL Recombinant Human LOX 293 Cell Lysate HEK293 N/A
    Human LOX-4734H Recombinant Human LOX Protein, GST-tagged Wheat Germ GST
    Human LOX-608H Recombinant Human lysyl oxidase, His-tagged E.coli His
    Human LOX-731H Recombinant Human LOX Protein, DDK/His-tagged HEK293 DDK/His
    Human LOX-7911H Recombinant Human LOX protein, His & GST-tagged E.coli His/GST
    Human LOX-89H Recombinant Human LOX, His-tagged HEK293 His
    Human LOX-90H Recombinant Human LOX, GST-tagged E.coli GST
    Mouse Lox-7912M Recombinant Mouse Lox protein, His & GST-tagged E.coli His/GST
    Mouse LOX-9184M Recombinant Mouse LOX Protein Mammalian Cell His
    Rat LOX-3432R Recombinant Rat LOX Protein Mammalian Cell His
    Chicken LOX-7030C Recombinant Chicken LOX Mammalian Cell His
    Zebrafish LOX-11818Z Recombinant Zebrafish LOX Mammalian Cell His
    Aerococcuss viridans LOX-41 Native Lactate Oxidase Aerococcuss viridans N/A
    Kit-0520 LOX Fluorometric Assay Kit N/A
    Kit-1061 Lipoxygenase Activity Assay Kit (Fluorometric) N/A

    LOX involved in several pathways and played different roles in them. We selected most pathways LOX participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of collagen fibrils and other multimeric structures COL5A3A; MMP13; COL2A1; COL1A1; LOXL1; COL6A3; CD151; LOX; BMP1A; COL3A1
    Collagen formation COL10A1; LOX; PPIB; COL9A1A; LEPREL1; COL25A1; COL17A1; CTSL2; LOXL3; COL1A1
    Crosslinking of collagen fibrils PCOLCE; LOXL1; ABHD1; BMP1B; BMP1A; LOX; TLL1; TLL2; LOXL2; LOXL3
    Elastic fibre formation FBN2; LOXL4; MFAP4; LTBP3; MFAP2; MFAP5; FURINB; LOXL1; BMP10; FBLN2
    Extracellular matrix organization SERPINH1B; CMA1; PTPRS; DDR2; CAPNS1; PCOLCEB; ELANE; CTRB1; COL8A1; EFEMP1

    LOX has several biochemical functions, for example, copper ion binding, protein binding, protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOX itself. We selected most functions LOX had, and list some proteins which have the same functions with LOX. You can find most of the proteins on our site.

    Function Related Protein
    copper ion binding SOD3A; S100A12; DCT; S100A5; LOXL5B; AOC2; ATP7B; LOX; MOXD1L; MT1
    protein binding GPRC5A; TUBB2B; CD27; CECR2; DDX6; L3MBTL4; ERCC5; RBM17; COLQ; CST2
    protein-lysine 6-oxidase activity LOXL3; LOX; LOXL2A; POLR1B; LOXL4; LOXL2; ABHD1; LOXL2B

    LOX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOX here. Most of them are supplied by our site. Hope this information will be useful for your research of LOX.

    EFEMP2; PTPRK; FBLN5; ELN; FBN1; GATAD2B; HSPA1A; COL1A1; COL3A1

    Hossain, E; Ota, A; et al. Lipopolysaccharide augments the uptake of oxidized LDL by up-regulating lectin-like oxidized LDL receptor-1 in macrophages. MOLECULAR AND CELLULAR BIOCHEMISTRY 400:29-40(2015).
    Camare, C; Trayssac, M; et al. Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. BRITISH JOURNAL OF PHARMACOLOGY 172:106-118(2015).

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