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SHH

  • Official Full Name

    sonic hedgehog

  • Overview

    This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
  • Synonyms

    SHH; sonic hedgehog; TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog protein; sonic hedgehog homolog;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • CHO
  • CHO-K1
  • E. coli
  • E. coli. This product is produced with no animal or human origin raw products.
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • C
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Met
  • Myc
  • DDK
  • N/A
  • N
  • SUMO
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SHH-606H Active Recombinant Human SHH, Met-tagged E.coli Met
Human SHH-01HG Active GMP Recombinant Human SHH Protein CHO-K1
Human SHH-486H Recombinant Human SHH Mammalian Cell His
Human SHH-30499TH Recombinant Human SHH N/A
Human SHH-7284H Recombinant Human SHH protein, His-tagged HEK293 His Cys 198-Ser 462
Human SHH-30498TH Recombinant Human SHH protein E.coli N/A 176
Human SHH-7285H Active Recombinant Human SHH protein(Met1-Gly197), His-tagged HEK293 C-His Met1-Gly197
Human SHH-1504H Recombinant Human Sonic Hedgehog Homolog (Drosophila) E.coli N/A
Human SHH-2484H Recombinant Human Sonic Hedgehog Homolog (Drosophila), His-tagged E.coli His
Human SHH-1533HCL Recombinant Human SHH cell lysate Human Cell N/A
Human SHH-1494HCL Recombinant Human SHH cell lysate Human Cell N/A
Human SHH-111HG Active GMP Recombinant Human SHH Protein E.coli N/A
Human SHH-240H Active Recombinant Human SHH Protein E.coli
Human SHH-3963H Recombinant Human SHH protein, His-tagged E.coli His 23-197 aa
Human SHH-36H Recombinant Human SHH Protein E.coli
Human SHH-4018H Recombinant Human SHH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SHH-312S Active Recombinant Human SHH Protein (C24IVI) (176 aa) E.coli 176
Human SHH-4055H-B Recombinant Human SHH Protein Pre-coupled Magnetic Beads HEK293
Human SHH-058S Active Recombinant Human SHH Protein (176 aa) E.coli 176
Human SHH-2603H Recombinant Human SHH protein E.coli N/A Cys24-Gly197 (Cys24Ile-Val-Ile)
Human SHH-313S Active Recombinant Human SHH Protein (C24II) (175 aa) E.coli 175
Human SHH-13HG Active Recombinant Human SHH Protein (Cys24-Gly197), C-His-tagged, GMP Grade, Animal-Free E.coli C-His Cys24-Gly197
Human SHH-14HG Active Recombinant Human SHH Protein (Cys24-Gly197, Cys24Ile-Ile), GMP Grade, Animal-Free E.coli Cys24-Gly197, Cys24Ile-Ile
Human SHH-4055H Recombinant Human SHH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SHH-527H Recombinant Human SHH Protein 462
Human SHH-07H Active Recombinant Human SHH Protein (Animal Free-Ready-to-Use) E.coli
Human SHH-08H Active Recombinant Human SHH Protein (Animal Free) E.coli
Human SHH-274H Recombinant Human SHH Protein (Gly25-Gly197, C24II), N-His-SUMO tagged, Animal-free, Carrier-free E.coli N-His-SUMO Gly25-Gly197
Human SHH-275H Active Recombinant Human SHH Protein (Gly25-Gly197, C24II), Animal-free, Carrier-free HEK293 Tag Free Gly25-Gly197
Human SHH-6284H Recombinant Human SHH Protein (Cys24-Gly197) E.coli Tag Free Cys24-Gly197
Human SHH-04H Active Recombinant Human SHH Protein, Pre-aliquoted E.coli Cys24-Gly197 (Cys24lle-lle), with N-terminal Met
Human SHH-1229H Recombinant Human SHH Protein, His-tagged HEK293F N-His Pro36-Ala193
Mouse Shh-9029M Active Recombinant Mouse Shh CHO N/A
Mouse SHH-1250M Acitve Recombinant Mouse SHH protein(Met1-Gly198), His-tagged HEK293 C-His Met1-Gly198
Mouse Shh-8701M Recombinant Mouse Shh, His tagged Human Cell N/A
Mouse Shh-1316M Recombinant Mouse Shh protein E.coli N/A 176
Mouse Shh-2363M Recombinant Mouse Sonic Hedgehog, His-tagged E.coli His
Mouse SHH-1176MCL Recombinant Mouse SHH cell lysate Human Cell N/A
Mouse Shh-206S Active Recombinant Mouse Shh Protein (176 aa) CHO 176
Mouse Shh-6803M Recombinant Mouse Shh Protein (Cys25-Gly198, Cys25Ile-Ile) E.coli Tag Free Cys25-Gly198, Cys25Ile-Ile
Mouse SHH-241M Recombinant Mouse SHH Protein E.coli
Mouse Shh-5863M Recombinant Mouse Shh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Shh-5862M Active Recombinant Mouse Shh Protein E. coli
Mouse Shh-6804M Recombinant Mouse Shh Protein (Cys25-Gly198) E.coli Tag Free Cys25-Gly198
Mouse Shh-7339M Recombinant Mouse Shh Protein, His-tagged E.coli His 25-198
Mouse SHH-852M Recombinant Mouse SHH Protein (Ile24-Gly198), His-tagged HEK293 His Ile24-Gly198
Mouse Shh-310S Active Recombinant Mouse Shh Protein (176 aa) E.coli 176
Mouse Shh-311S Active Recombinant Mouse Shh Protein (C25II) (175 aa) E.coli 175
Rat Shh-1857R Recombinant Rat Shh protein, His & T7-tagged E.coli His/T7 Ser237~Arg399 (Accession # Q63673)
Rat Shh-1856R Recombinant Rat Shh protein, His-tagged E.coli His Gly28~Val192 (Accession # Q63673)
Rat SHH-5391R Recombinant Rat SHH Protein Mammalian Cell His
Rat SHH-5050R Recombinant Rat SHH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SHH-5050R-B Recombinant Rat SHH Protein Pre-coupled Magnetic Beads HEK293
Rat SHH-242R Recombinant Rat SHH Protein E. coli. This product is produced with no animal or human origin raw products.
Chicken SHH-6384C Recombinant Chicken SHH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SHH Related Articles

SHH involved in several pathways and played different roles in them. We selected most pathways SHH participated on our site, such as Hedgehog signaling pathway, Pathways in cancer, Basal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hedgehog signaling pathwayWNT8A;PRKACAA;PRKACB;WNT8B;BTRC;CSNK1G1;CSNK1G2B;SHHA;GLI1
Pathways in cancerFGF1;BRCA2;GNAI3;Flt3l;RXRB;SPI1;BCL2;TCF7L2;FGFR2
Basal cell carcinomaFZD3;WNT8A;WNT4;WNT10B;GSK3B;FZD9;WNT11;TRP53;Shh

SHH has several biochemical functions, for example, calcium ion binding, glycoprotein binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHH itself. We selected most functions SHH had, and list some proteins which have the same functions with SHH. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingGCA;PCDHGC3;CDH13;PCDH2G10;ANXA2;FAT2;ITSN2;EGF;SYT5B
glycoprotein bindingITGAM;LDLR;CSNK1D;FYN;Shh;AZGP1;TFRC;LMAN2;EDEM2
glycosaminoglycan bindingBGN;DCN;VIT;EPYC;ENG;EGFLAM;Shh;CCDC80;PODXL2
laminin-1 bindingDAG1;LACRT;UBE4A;Shh;NID1;NTN4;SLIT2
morphogen activityGREM1;NODAL;NBL1;DAND5;Shh;CER1
patched bindingCCNB1;SETD6;Shh;CAV1;IHH;PTCH1;BBS1;SMO;DHH
peptidase activityCASP8;AGBL4;PPPDE2;IWS1;LGMN;CASPB;CAPN8;CAPN5A;KLK1B5
protein bindingGTF3C6;SCNN1D;PLEKHH2;EDA;CASP14;DCTPP1;H3F3C;HIST1H1A;CAV2
zinc ion bindingNR2E1;LMO7B;EWSR1A;ARIH1L;ERAP2;PHF21B;WTIP;SP140L;CNBPA

SHH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHH here. Most of them are supplied by our site. Hope this information will be useful for your research of SHH.

Choe, JY; Yun, JY; et al. Sonic hedgehog signalling proteins are frequently expressed in retinoblastoma and are associated with aggressive clinicopathological features. JOURNAL OF CLINICAL PATHOLOGY 68:6-11(2015).
Liu, ZQ; Xu, JD; et al. A critical role of autocrine sonic hedgehog signaling in human CD138(+) myeloma cell survival and drug resistance. BLOOD 124:2061-2071(2014).
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