tnfrsf1b
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  • Official Full Name
  • tumor necrosis factor receptor superfamily, member 1B
  • Background
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2
Cat.#:Tnfrsf1b-847MTag:N/A
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf1b protein
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Cat.#:TNFRSF1B-164HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF1B
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Cat.#:TNFRSF1B-165HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human TNFRSF1B, Fc Chimera
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Cat.#:TNFRSF1B-1689HTag:Fc|His
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFRSF1B, Fc&His-tagged
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Cat.#:TNFRSF1B-178HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1B, Fc-His tagged
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Cat.#:TNFRSF1B-193HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1B, His tagged
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Cat.#:TNFRSF1B-249HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF1B protein
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Cat.#:TNFRSF1B-285HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1B, His tagged
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Cat.#:TNFRSF1B-31574THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human TNFRSF1B, Fc-tagged
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Cat.#:TNFRSF1B-31575THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF1B, His-tagged
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Cat.#:TNFRSF1B-386HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TNFRSF1B
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Cat.#:TNFRSF1B-5270HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TNFRSF1B protein
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Cat.#:TNFRSF1B-62HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TNFRSF1B protein, His-tagged
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Cat.#:TNFRSF1B-66HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNF-R2, Fc-tagged
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Cat.#:TNFRSF1B-7055HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF1B protein, His & GST-tagged
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Cat.#:TNFRSF1B-708HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TNFRSF1B, Fc-tagged, Biotinylated
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Cat.#:TNFRSF1B-80HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNF Receptor 2 protein, His-tagged
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Cat.#:Tnfrsf1b-3259MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfrsf1b, Fc tagged
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Cat.#:Tnfrsf1b-3274MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfrsf1b, His tagged
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Cat.#:Tnfrsf1b-7056MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf1b protein, His-tagged
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Cat.#:TNFRSF1B-6198RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNFRSF1B Protein
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Cat.#:Tnfrsf1b-7057RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnfrsf1b protein, His & T7-tagged
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Cat.#:TNFRSF1B-70CTag:Fc|His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFRSF1B, Fc tagged
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Cat.#:TNFRSF1B-8828CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFRSF1B, His tagged
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Cat.#:TNFRSF1B-4869RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TNFRSF1B Protein, His-tagged
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Cat.#:TNFRSF1B-6009CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNFRSF1B
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Cat.#:TNFRSF1B-5605ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TNFRSF1B
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Cat.#:TNFRSF1B-125HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human soluble tumor necrosis factor receptor superfamily, member 1B, His-tagged
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Cat.#:TNFRSF1B-153HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1B, Fc Chimera
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Cat.#:TNFRSF1B-180HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF1B
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Cat.#:TNFRSF1B-2349HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1B, Fc-His
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Cat.#:TNFRSF1B-76HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TNFRSF1B
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Cat.#:TNFRSF1B-2632HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1B cell lysate
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Cat.#:TNFRSF1B-851HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1B cell lysate
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Cat.#:TNFRSF1B-2192MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TNFRSF1B cell lysate
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Cat.#:TNFRSF1B-1048CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFRSF1B cell lysate
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Cat.#:TNFRSF1B-126HTag:N/A
Source (Host):Species:Human
Product nameHuman Soluble Tumor Necrosis Receptor factor Type II (rDNA derived) Reference standard
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Involved Pathway

TNFRSF1B involved in several pathways and played different roles in them. We selected most pathways TNFRSF1B participated on our site, such as Cytokine-cytokine receptor interaction, TNF signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL22RA2; TNFRSF25; FIGF; CXCR4; IL26; CCL20B; IL17B; IL1R2; IL1A; CCR9A
TNF signaling pathway
TNFRSF1A; MAPK1; PIK3CA; CASP7; CCL2; PIK3CD; BCL3; BIRC2; PTGS2; SELE
Adipocytokine signaling pathway
ACSL1; TRADD; G6PC3; JAK2; CD36; JAK2B; IKBKB; NFKBIE; MAPK8; ACSL3B
Amyotrophic lateral sclerosis (ALS)
TP53; TRP53; PPP3CA; TNFRSF1A; MAPK14; TNF; MAP2K6; APAF1; BID; PRPH

Protein Function

TNFRSF1B has several biochemical functions, for example, protein binding, tumor necrosis factor-activated receptor activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF1B itself. We selected most functions TNFRSF1B had, and list some proteins which have the same functions with TNFRSF1B. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein F11; ZZZ3; PLEC; VAPA; PIP4K2B; CAMKK1; LRP2; ORC1L; SPSB3; UCP3
Function tumor necrosis factor-activated receptor activity
Related Protein TNFRSF6B; TNFRSF11A; TNFRSF14; NGFRB; TNFRSF19; NRADD; CD27; TNFRSF21; TNFRSF8; Tnfrsf26
Function ubiquitin protein ligase binding
Related Protein TNFRSF14; TRIM37; ERBB2; USP25; UBE2G1B; USP13; RNF31; WASH; LYN; PER3

Interacting Protein

TNFRSF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF1B.
GRN; TNF; TRAF2; TNF; TUBB3; HAX1; IRS4; CDIPT; XPO1; ATP2A1; IPO8; PHGDH; XPOT

TNFRSF1B Related Articles

Zhong, H; Bussel, J; et al. In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. BRITISH JOURNAL OF HAEMATOLOGY 168:274-283(2015).
Kolorz, M; Wroblova, K; et al. Pharmacogenomics of infliximab therapy, impact of TNFRSF1A and TNFRSF1B gene polymorphisms. BIOMEDICAL PAPERS-OLOMOUC 157:S75-S78(2013).

TNFRSF1B Related Gene Family

TNF Cytokines