TP53
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Official Full Name
tumor protein p53
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Overview
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013] -
Synonyms
TP53; tumor protein p53; P53; BCC7; LFS1; TRP53; cellular tumor antigen p53; antigen NY-CO-13; tumor protein 53; phosphoprotein p53; p53 tumor suppressor; mutant tumor protein 53; transformation-related protein 53;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus
- Cynomolgus Monkey
- Human
- Human
- Monkey
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Yeast
- C
- His
- Avi
- cMyc,GST
- DDK
- Flag
- GST
- His (Fc)
- SUMO
- Myc
- Myc|DDK
- N/A
- N
- MBP
- Strep
- Involved Pathway
- Protein Function
- Interacting Protein
- TP53 Related Articles
- TP53 Related Signal Pathway
TP53 involved in several pathways and played different roles in them. We selected most pathways TP53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAP2K6;MAPK6;HSP70;CDC25B;FGF5;MAPK8;STK4;FGF20;RELB |
| Sphingolipid signaling pathway | BCL2;PIK3CD;PIK3CA;PLD1;TRAF2;DEGS2;MAPK3;LASS5;PLD2 |
| Cell cycle | CSNK1D;TP53;RAD21A;CDKN1BA;SKP1;CENPW;PSMC3IP;PTTG2;SMAD3A |
| p signaling pathway | ZMAT3;CYCSB;Casp3;CCNB1;CD82B;CD82A;BAI1;PPM1DB;TP73 |
| PIK-Akt signaling pathway | BCL2;CREB3L2;PPP2R3A;AKT1;FGF18;CCNE2;TP53;Ifna15;FN1 |
| Apoptosis | CDKN2A;PPP3CCB;BIRC5A;APAF1;CYCSB;HMGB2;YWHAQ;STK24B;HIST1H1A |
| Wnt signaling pathway | TCF7L2;NKD2;WNT11;FZD7A;CCND2A;FZD2;PRKCBB;SMAD4;SFRP1A |
| Neurotrophin signaling pathway | MAP3K5;CALM4;NTF3;SHC4;YWHAE;NTF4;ARHGDIG;RPS6KA5;RELA |
| Thyroid hormone signaling pathway | MDM2;MED4;PRKCB;SLC16A10;SLC9A1;NRAS;HDAC3;RCAN1;TP53 |
| Amyotrophic lateral sclerosis (ALS) | TOMM40L;RAC1;MAPK13;APAF1;GRIA1;MAPK14;BCL2L1;SOD1;TNFRSF1A |
| Huntingtons disease | NDUFV1;UQCRH;NDUFB2;NDUFA8;NDUFC1;SDHC;SDHA;NDUFA7;MT-ATP6 |
| Hepatitis C | PPP2CA;IFNB1;PIK3CG;HRAS;CLDN22;GRB2;PPP2R2A;PIK3R2;PPARA |
| Hepatitis B | MYD88;IFN-a;CCND1;KRAS;PRKCG;IFNB1;PIK3R1;IRF7;TP53 |
| Measles | AKT2;IL2RA;CCND1;CD3G;IFNA12;OAS1B;Il2;GSK3B;FYN |
| HTLV-I infection | DVL3;IL15RA;CDC16;ANAPC4;WNT3A;FZD9;HLA-DRB1;TERT;TSPO |
| Herpes simplex infection | IFNAR2;SRSF1A;IRF7;RELA;IFN-a;SRSF2A;IKBKE;MAPK8B;FADD |
| Epstein-Barr virus infection | TBPL1;IRF3;NCOR2;HLA-DRB5;CD19;CSNK2B;AKAP8L;HLA-DPA1;ENTPD8 |
| Pathways in cancer | WNT3A;PTGS2;PIK3CG;APPL1;KIT;IGF1R;FGF9;CBLB;FAS |
| Transcriptional misregulation in cancer | ELK4;MAX;TRP53;DDX5;FCGR1A;H3F3A;MLLT3;NCOR1;PLAU |
| Viral carcinogenesis | HDAC10;PIK3R2;HDAC7A;SCRIB;HIST2H2BE;CREB3L2;NFKB2;YWHAG;NFKB1 |
| Proteoglycans in cancer | SRC;COL21A1;HCLS1;MET;RRAS;SMAD2;PRKCG;FGFR1;PRKACG |
| MicroRNAs in cancer | HDAC1;SOX4;IGF2BP1;TGFB2;HMGA2;PLCG2;NOTCH2;RPTOR;CD44 |
| Colorectal cancer | PIK3CB;APC2;CYCS;KRAS;MAPK1;PIK3R2;TGFBR1;RHOA;AKT2 |
| Pancreatic cancer | KRAS;MAPK3;STAT1;MAP2K1;RB1;SMAD4;PIK3CB;RELA;TGFBR1 |
| Endometrial cancer | PIK3R2;PIK3R3;AKT2;TCF7;APC2;MAPK1;ERBB2;HRAS;MLH1 |
| Glioma | MAP2K2;PLCG1;CALM1;PTEN;PRKCB;MAPK3;AKT1;PIK3CD;ARAF |
| Prostate cancer | SPINK1;NKX3-1;ACTL6B;TCF7;FOXO1;PIK3CG;NOXA1;BCL2;CASP9 |
| Thyroid cancer | MAPK1;TPR;MAPK3;NCOA4;PAX8;RET;NRAS;CDH1;TP53 |
| Basal cell carcinoma | LEF1;TCF7;WNT16;BMP2;TP53;WNT8A;APC2;BMP4;TRP53 |
| Melanoma | FGF8;FGF13;AKT2;PDGFD;MAP2K1;RAF1;PIK3R3;MAPK3;IGF1 |
| Bladder cancer | SRC;NRAS;UPK3A;DAPK3;DAPK1;FGFR3;RB1;CDKN2A;E2F1 |
| Chronic myeloid leukemia | TGFB2;AKT2;ARAF;RB1;SHC3;GAB2;KRAS;BAD;PIK3R5 |
| Small cell lung cancer | TRAF1;LAMA1;CCND1;AKT2;PIK3CD;PIK3R5;ITGA2B;FHIT;NFKB1 |
| Non-small cell lung cancer | MAP2K1;PIK3R2;CASP9;FOXO3;TGFA;EML4;PIK3CD;PRKCB;RASSF5 |
| Central carbon metabolism in cancer | FLT3;C12orf5;PFKL;HK3;PTEN;HK2;G6PDX;PDHA2;SLC7A5 |
TP53 has several biochemical functions, for example, ATP binding, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP53 itself. We selected most functions TP53 had, and list some proteins which have the same functions with TP53. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MET;STK24B;PRKCZ;SKIV2L2;DHX35;PIK3CG;PRKCBA;CDC42BPA;CLP1 |
| DNA binding | NR1D2B;IRF1B;RECQL;POT1A;SMTNL;PCGF2;PKNOX1.1;RAD51D;ESR2B |
| RNA polymerase II core promoter sequence-specific DNA binding | SP3;YAP1;GBX2;FOS;TFAP2B;H2AFY;SOX3;RREB1;EP300 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXD1L;FOXO4;ZNF174;ZMYM5;ZNF18;SOX5;RUNX2;TFAP2A;BHLHE40 |
| RNA polymerase II transcription factor binding | GATA1A;GATA1;DHX9;GATA3;TAL1;SFPI1;GFI1B;ZFPM2A;TRP53 |
| chaperone binding | DNAJB4;SLC25A17;HSCB;SYVN1;CALR;HES1;AHSA2;RNF207;TG |
| chromatin binding | URI1;CALCOCO1;CAMTA2;TCF3;CHAF1A;GLI1;SSRP1;PPARGC1A;TRP53 |
| copper ion binding | PARK7;F8;POLR1B;LOXL2A;LOXL2;HEPHL1;LOXL4;SOD1;ABP1 |
| core promoter sequence-specific DNA binding | SOX1;PROX1;ZFP750;TOP1;PRMT5;SP1;SOHLH2;CRY1;TRP53 |
| damaged DNA binding | PCNA;POLB;RAD18;GTF2H3;EP300;FEN1;RUVBL2;TP63;CRY2 |
| double-stranded DNA binding | AKAP8;FEV;RBMS1;NEIL3;PNKP;XRCC2;TP53;KIN;HLF |
| enzyme binding | PPP1R3B;H2AFX;UGT1A6;POLB;PUS7;C6orf211;PHB;RPS19BP1;SNX12 |
| histone acetyltransferase binding | TRIM68;TAF7;CITED2;CEBPB;FOXP3;NR4A3;TRIP4;CREB1;HIF1A |
| histone deacetylase regulator activity | TP53;TRP53;NCOR1;MAPK8 |
| identical protein binding | CEP170L;STAT2;HTT;S100A1;ADIPOR1;FAS;LYZ1;MYOM1;REG3B |
| p53 binding | CREBBP;ZMAT4;TRIAP1;ZNF385C;ZMAT3;TRP53;RNF20;SMARCA4;ZFP385C |
| protease binding | BDKRB2;OS9;SEMG2;Serpina1b;INS;TIMP2B;FADD;CNTNAP2;SERPINA1E |
| protein N-terminus binding | PARP1;TAF11;ZWINT;VWF;EIF3E;ARF6;MNAT1;TARBP2;RELA |
| protein binding | AP1S2;EIF5A2;NXF3;THOC5;AMY1B;CREBBP;BORA;GAD2;EXOC3L |
| protein heterodimerization activity | HIST1H2BN;GUCY1A3;LIMK1;H2AFV;ABCG1;UGT1A3;HIST1H2A9;ATF6;ATP4A |
| protein kinase binding | CENPJ;TMEM173;LIPE;AXIN2;FBXO5;PGAM1;VRK1;SKI;TTN |
| protein phosphatase 2A binding | ENSAA;ENSA;HMGCR;SMG5;TRP53;STRN;EIF4EBP1;RPS6KB1;ANKLE2 |
| protein phosphatase binding | PIK3R1;CTNNB1;MAPK14;Itga10&Itgb1;SHOC2;JAK1;VCP;LCK;HSP90B1 |
| protein self-association | ZSWIM2;ZFP639;RYR2;S100A7A;NKX3-1;SLC2A1;ACHE;AGTR1A;DYRK1A |
| receptor tyrosine kinase binding | GNB2L1;DOCK4;HYAL2;DNAJA3;GAS6;TP53;ANGPT2;ZFP259;ANGPT4 |
| sequence-specific DNA binding | NR2F1A;PAX7A;PRRX1A;Trl;PAX6B;FLI1B;CDX1A;FOXA1;IRX5B |
| transcription factor activity, sequence-specific DNA binding | GATAD1;PA2G4B;ZNF238;MEF2A;FOXP2;ZFY1;TADA3;FOXO4;VDRA |
| transcription factor binding | POU5F1;CEBPA;HDAC11;TRERF1;TAF7;ARID5A;MDFIC;HEY1;PARD6A |
| transcription regulatory region DNA binding | CEBPA;CCNT1;IKZF1;CREB3L1;TBL1X;CTCF;GRHL1;HIVEP2;RREB1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NRF1;MTF1;FOXI1;NCOA3;NR1H4;MEF2A;PPARA;TFAP2E;FOXC2 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MAFG;TRP53;RXRB;MAFF;FEZF2;TBX5;MYF5;GATA5;STAT3 |
| ubiquitin protein ligase binding | SNCAIP;NDUFS2;CDC34;WASH1;USP13;BCL10;MDM2;XBP1;UQCRC1 |
| zinc ion binding | ZDHHC15B;TRIM35-24;AGBL3;LIN28B;FTR72;GATA4;MATR3L;SLU7;CPO |
TP53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP53 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP53.
MDM2
- Q&As
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Q&As (5)
Ask a questionYes, identifying TP53 mutations in families with a history of early-onset cancers can help identify individuals at high risk for cancer and guide screening and prevention strategies.
TP53 mutations are highly diverse, making it challenging to develop a one-size-fits-all therapy. Additionally, the p53 pathway is complex, and disrupting it can have unintended consequences.
Yes, TP53 mutation status can be a criterion for eligibility in specific clinical trials, especially those testing experimental treatments that may target the p53 pathway.
TP53 status can influence treatment decisions. For example, patients with TP53 mutations may require more aggressive treatment approaches or different chemotherapy regimens.
Currently, there are no specific targeted therapies approved solely for TP53-mutated cancers. However, research is ongoing to develop drugs that target the altered p53 pathway.
Customer Reviews (3)
Write a reviewBy actively engaging with researchers and understanding their needs, manufacturers can contribute significantly to the success and impact of research involving the TP53 protein.
This flexibility allows for tailored approaches and provides researchers with more options to study specific aspects of TP53 biology or its interactions with other molecules.
Manufacturers can provide comprehensive product information, including data on the functionality, stability, and handling of TP53 protein.
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