tp53
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  • Official Full Name
  • tumor protein p53
  • Background
  • This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
  • Synonyms
  • TP53; tumor protein p53; P53; BCC7; LFS1; TRP53; cellular tumor antigen p53; antigen NY-CO-13; tumor protein 53; phosphoprotein p53; p53 tumor suppressor; mutant tumor protein 53; transformation-related protein 53;
Cat.#:TP53-1076HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P53
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Cat.#:TP53-15HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53 protein, GST-tagged
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Cat.#:TP53-170HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Protein P53
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Cat.#:TP53-171HTag:Myc/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TP53 Protein, Myc/DDK-tagged
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Cat.#:TP53-172HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TP53 Protein, DDK-tagged
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Cat.#:TP53-185HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53 protein
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Cat.#:TP53-26HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30262THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53
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Cat.#:TP53-30547THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, GST-tagged
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Cat.#:TP53-30570THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30571THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30572THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30573THTag:GST
Source (Host):Species:Human
Product nameRecombinant Human TP53, GST-tagged
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Cat.#:TP53-31456THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53
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Cat.#:TP53-3412HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-3436HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-3445HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-58HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-611HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-75HTag:Flag
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TP53 protein, Flag-tagged
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Cat.#:Tp53-5633RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tp53 protein, His-tagged
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Cat.#:TP53-6230RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TP53 Protein
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Cat.#:TP53-1044CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TP53 Protein, His-tagged
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Cat.#:TP53-1162CTag:
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TP53 Protein
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Cat.#:TP53-4910RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TP53 Protein, His-tagged
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Cat.#:TP53-6816CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TP53
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Cat.#:TP53-8275ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TP53
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Cat.#:TP53-325HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P53, GST-tagged
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Cat.#:TP53-1077HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Protein P53, GST-tagged
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Cat.#:TP53-860HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TP53 293 Cell Lysate
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Involved Pathway

TP53 involved in several pathways and played different roles in them. We selected most pathways TP53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNG1A; MKNK2B; JIP1; MAP3K12; CACNG4; Fgf15; TGFB1; EGFRA; PLA2G4D; CACNG6A
Sphingolipid signaling pathway
BAX; TRADD; AKT2; SGMS2; GNA12; LASS5; PTEN; CERS2; BDKRB2; PRKCE
Cell cycle
KAT5; CEP135; DCTN3; CEP57; TOP2A; BRCC3; LIN54; VRK2; NDEL1B; CUL1B
p signaling pathway
PPM1DA; TP53; SIAH2L; GADD45BA; RPRMA; IGF1; COP1; SFN; SIAH1; PTENA
PIK-Akt signaling pathway
LAMB4; MTOR; ITGA1; RELA; KRAS; IBSP; FGF20; GNG8; TNN; LAMB3
Apoptosis
MAP3K14; PIK3R2; TNFRSF10C; CRADD; IL1R1; PIK3R3A; PPP3CA; CAPN1B; HIST1H1C; CFLAR
Wnt signaling pathway
FOSL1; WNT10B; PRKACAA; RUVBL1; SKP1; DAAM2; MAPK8B; CER1; FZD5; DAAM1
Neurotrophin signaling pathway
CAMK2A; ATF4; RPS6KA6; NRAS; CALM1; PIK3R3; TP73; YWHAE; NGFRAP1; PIK3CD
Thyroid hormone signaling pathway
PIK3R5; STAT1; NCOA1; BMP4; SIN3A; PLCD4; NOTCH1; PRKACB; MED13; ITGB3
Amyotrophic lateral sclerosis (ALS)
DERL1; TP53; BAX; GRIN2C; TNF; PPP3R2; PPP3R1; NEFH; MAP2K6; RAC1
Huntingtons disease
ITPR1; COX7A1; HAP1; DCTN1; SDHD; CREB3L2; EP300; HDAC2; UQCR11; NDUFB7
Hepatitis C
IFNA2; IFIT1; IFNA14; EIF2AK1; PIK3R2; NFKBIA; BAD; PIK3CB; CD81; RELA
Hepatitis B
CASP10; MAP2K1; BCL2; CXCL8; AKT2; DDB2; MAVS; VDAC3; CCNE2; EGR3
Measles
OAS1B; cgr2b; HSPA1A; STAT3; IFNA16; IFNA10; IL12B; MX1; FAS; PIK3CB
HTLV-I infection
SRF; CCND2; PTTG1; PDGFB; FZD3; HLA-DQA1; ELK4; TNFRSF1A; TNF; ATF1
Herpes simplex infection
HLA-DQB1; IRF7; HLA-DPB1; TRAF3; CFP; ALYREF; STAT2; ABCB3L1; GTF2IRD1; IFIT1
Epstein-Barr virus infection
IKBKB; XPO1; RELB; SND1; SKP2; NFKB2; SPI1; SNW1; TP53; PSMD12
Pathways in cancer
WNT7B; CSF3R; FGF16; GNG10; TRP53; AGTR1A; Fasl; LAMC2; RXRA; HHIP
Transcriptional misregulation in cancer
ATM; MAF; PFTK1; BCL2A1A; Itgam&Itgb2; CEBPE; SFPI1; CDK14; MLLT1; TMPRSS2
Viral carcinogenesis
PRKACA; HIST1H4E; GTF2B; EGR3; BAX; HIST2H4; H2BFWT; ATF4; PKM2; PIK3R2
Proteoglycans in cancer
HIF1A; FZD3; MET; Ctsl; VAV2; PLCE1; ITPR3; CAV1; TIMP3; TRP53
MicroRNAs in cancer
ABL1; HMGA2; THBS1; CCNG1; SOCS1; CCND1; IRS1; VEGFA; Abcb1b; ROCK1
Colorectal cancer
RAC2; LEF1; PIK3R2; TCF7; RAF1; MSH2; RAC1; AXIN1; BIRC5; PIK3R5
Pancreatic cancer
AKT1; CDC42; PIK3CB; TGFBR2; VEGFA; ARAF; RALB; IKBKG; RAC3; RALGDS
Endometrial cancer
SOS1; CTNNA2; KRAS; MAPK1; ILK; ARAF; GSK3B; PDPK1; TCF7L2; ELK1
Glioma
RAF1; PIK3R1; PIK3R2; PRKCG; CAMK2A; PIK3CD; TRP53; PDGFRB; MAPK3; PDGFA
Prostate cancer
KRAS; PDGFC; HSP90B1; BAD; CCNE2; PIK3CB; PIK3CA; HRAS; FGFR1; GSTP1
Thyroid cancer
RET; MAP2K2; RXRG; PAX8; LEF1; MAPK3; MAPK1; TCF7L2; RXRA; CCDC6
Basal cell carcinoma
WNT16; WNT2B; WNT6; Fzd4; DVL3; GLI3; TCF7; SETD6; FZD1; APC2
Melanoma
MITF; PDGFRA; TRP53; BAD; FGF21; MAP2K2; MDM2; FGF10; CCND1; FGF8
Bladder cancer
VEGFA; E2F2; DAPK3; MMP1A; MAPK3; TP53; DAPK2; TRP53; TYMP; FGFR3
Chronic myeloid leukemia
PIK3CG; MECOM; HDAC2; PIK3CB; TGFB1; BCL2L1; HRAS; TGFBR1; CTBP2; TRP53
Small cell lung cancer
TRAF5; PTEN; TRAF4; AKT1; TP53; AKT2; CCNE2; CASP9; ITGAV; SKP2
Non-small cell lung cancer
PIK3R1; GRB2; PIK3CG; PIK3CD; ARAF; TRP53; PIK3R2; PDPK1; PRKCB; RXRA
Central carbon metabolism in cancer
PDGFRA; PTEN; G6PDX; KRAS; PKM2; GLS; SCO2; HK3; G6PD; SLC2A1

Protein Function

TP53 has several biochemical functions, for example, ATP binding, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP53 itself. We selected most functions TP53 had, and list some proteins which have the same functions with TP53. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CLCN7; GSK3A; EHD3; DDX20; NME1; GLULB; MLKL; DDX25; MCM9; GRK7A
Function DNA binding
Related Protein MIER1B; PPP1R8; ZNF582; DNASE1L3; H2AFB1; ZBED3; ZIC5; RXRBB; ZFP865; ZNF800
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein STAT6; EP300; SP1; GBX2; H3F3A; MITF; RREB1; SMAD1; H2AFZ; PAX6
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein SOX9A; BETA3; ARX; FOXD1L; SP3A; JUN; JUNBA; ZMYM5; TWIST1; ETV6
Function RNA polymerase II transcription factor binding
Related Protein XBP1; MTDH; GATA2; TP53; GSK3B; MKX; ID4; GATA1A; MEF2A; TBX6
Function chaperone binding
Related Protein TBCE; ATP1A2; SDF2L1; HLA-B; TRP53; BAG4; TIMM44; DNAJB8; TBCC; DNAJA3A
Function chromatin binding
Related Protein NUPR1; RNF2; ELK4; SSRP1; EED; HINFP; LEF1; FLI1; BAP1; SVEP1
Function copper ion binding
Related Protein SOD1; S100A5; LOXL1; LOXL3A; F8; LOXL2A; SCO1; P2RX4; PRNP; ATP7A
Function core promoter sequence-specific DNA binding
Related Protein NFYA; PRMT5; SOHLH1; ESR2; KLF10; THRAP3; RORA; SP1; SOX9; MTA1
Function damaged DNA binding
Related Protein CRY-DASH; RAD23B; HMGB2; RAD23AA; TDG; RAD23A; XPC; MPG; OGG1; FEN1
Function double-stranded DNA binding
Related Protein MTERF2; FEV; TP63; CTNNB1; SETMAR; NKX2-8; CGGBP1; PRKDC; PYDC3; GATA1A
Function enzyme binding
Related Protein HIF1A; UGT1A2; Slc4a2; CYP1A1; TSPAN33; PTEN; TTN; RXRA; HOXA9; CYP2E1
Function histone acetyltransferase binding
Related Protein HIF1A; EID1; TRIM68; CREB1; ZBTB7A; MEF2A; KAT2B; CEBPB; EPAS1; SP1
Function histone deacetylase regulator activity
Related Protein MAPK8; TRP53; NCOR1; TP53
Function identical protein binding
Related Protein NIF3L1; PFKL; SP100; PLEKHH2; IK; SH3GLB1; RYR2; CORO1B; DIAP1; TTR
Function p53 binding
Related Protein CHD8; EP300; ZNF385C; ZFP346; TP53RK; GATA1; TP73; SETD8; SMYD2; TP53
Function protease binding
Related Protein SERPINF2; IL1R1; PANX1; CNTNAP2; ITGAV; OS9; ITGB3; TYSND1; SERPINB6; SERPINB4
Function protein N-terminus binding
Related Protein SMARCA4; NCOR2; NBN; UNC13A; STXBP1; TGFB1; EXOC4; TARBP2; TSC1; NTSR1
Function protein binding
Related Protein TBL1XR1; SPCS1; STAU1; DENR; ERAP1; BAK1; NMU; PRPF31; PEA15; CYP1A1
Function protein heterodimerization activity
Related Protein MAPK4; TPD52L1; BIK; BAX; RALGAPA1; TP53; PVRL1; BOKA; MCL1; HIST1H2BE
Function protein kinase binding
Related Protein ATG13; AGTR1A; AXIN2; DLG1L; NR4A3; FBXO7; MAPK8IP2; TICAM1; RPTOR; CCND2
Function protein phosphatase 2A binding
Related Protein RPS6KB1; PTPN1; ENSA; MASTL; SHC1; FOXO1; ENSAA; EIF4EBP1; TP53; AKT1
Function protein phosphatase binding
Related Protein RPA3; PIK3R1; EGFR; CSF1R; PARD3; PPME1; MAP2K7; JUPA; ROS1; CDC27
Function protein self-association
Related Protein CBR2; SLC2A1; BCL10; ACVR2A; ACHE; TP53; AGTR1A; PROSAPIP1; RYR2; CNTN2
Function receptor tyrosine kinase binding
Related Protein PTPN14; PTPN1; GAS6; ARHGEF16; PLCG1; FLT3LG; TP53; SQSTM1; PITPNM3; PCNA
Function sequence-specific DNA binding
Related Protein FOXJ1B; SPDEF; SALL1; CSRNP1; HOXD10A; MSXC; DHARMA; SOX2; DBPA; ZNF187
Function transcription factor activity, sequence-specific DNA binding
Related Protein UBP1; MNX1; CEBPD; CTCF; HSF4; SOLH; RARAA; CREM; ELF3; FOXA1
Function transcription factor binding
Related Protein CAMTA2; KAT6B; DOT1L; HMGB2; ATOH8; GTF2B; NCOA2; FOXA3; KEAP1; THRA
Function transcription regulatory region DNA binding
Related Protein Arid4b; CTCF; KLF11; FOXM1; HIVEP2; NKX2-1; SOX7; TP53; SALL1A; SOX6
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CARF; MYB; TFAP2B; ONECUT2; TLX1; MYC; CAMTA2; MEF2B; TFAM; MTF1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein STAG1; IKZF3; CSRNP2; ARID3A; SOHLH1; MAF; MAFK; GABPA; PLAGL1; OVOL2
Function ubiquitin protein ligase binding
Related Protein CUL2; UCHL1; STUB1; H2-AB1; UBE2R2; FAF2; PIAS2; BECN1; UBE2V2; DIO2
Function zinc ion binding
Related Protein QPCTL; MDM4; LNX2A; GATA2; SETDB1A; KDM5C; TRIM38; POLR3K; JHDM1D; CA5B

Interacting Protein

TP53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP53 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP53.
MDM2

TP53 Related Articles

Sadahira, Y; Sugihara, T; et al. WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome. VIRCHOWS ARCHIV 466:343-350(2015).
Fuentes-Raspall, MJ; Caragol, I; et al. Apoptosis for prediction of radiotherapy late toxicity: lymphocyte subset sensitivity and potential effect of TP53 Arg72Pro polymorphism. APOPTOSIS 20:371-382(2015).