tp53
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  • Official Full Name
  • tumor protein p53
  • Background
  • This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
  • Synonyms
  • TP53; tumor protein p53; P53; BCC7; LFS1; TRP53; cellular tumor antigen p53; antigen NY-CO-13; tumor protein 53; phosphoprotein p53; p53 tumor suppressor; mutant tumor protein 53; transformation-related protein 53;
Cat.#:TP53-983HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TP53 Protein, His-tagged
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Cat.#:TP53-1076HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P53
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Cat.#:TP53-15HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53 protein, GST-tagged
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Cat.#:TP53-170HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Protein P53
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Cat.#:TP53-171HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TP53 Protein, Myc/DDK-tagged
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Cat.#:TP53-172HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TP53 Protein, DDK-tagged
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Cat.#:TP53-185HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53 protein
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Cat.#:TP53-26HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30262THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53
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Cat.#:TP53-30547THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, GST-tagged
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Cat.#:TP53-30570THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30571THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30572THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30573THTag:GST
Source (Host):Species:Human
Product nameRecombinant Human TP53, GST-tagged
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Cat.#:TP53-31456THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53
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Cat.#:TP53-3412HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-3436HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-3445HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-58HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-611HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-75HTag:Flag
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TP53 protein, Flag-tagged
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Cat.#:Tp53-5633RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tp53 protein, His-tagged
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Cat.#:TP53-6230RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TP53 Protein
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Cat.#:TP53-1044CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TP53 Protein, His-tagged
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Cat.#:TP53-1162CTag:N/A
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TP53 Protein
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Cat.#:TP53-4910RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TP53 Protein, His-tagged
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Cat.#:TP53-6816CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TP53
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Cat.#:TP53-8275ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TP53
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Cat.#:TP53-325HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P53, GST-tagged
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Cat.#:TP53-1077HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Protein P53, GST-tagged
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Cat.#:TP53-860HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TP53 293 Cell Lysate
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Involved Pathway

TP53 involved in several pathways and played different roles in them. We selected most pathways TP53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNA2D1; NR4A1; MAPK8B; SRFA; MAP4K4; JUND; FGF6A; DUSP16; FGFR3; HSPA2
Sphingolipid signaling pathway
PPP2R5C; SPTLC2; SPHK1; PRKCA; MAP2K1; PPP2CB; PLCB1; OPRD1; SGPL1; RELA
Cell cycle
KIF2C; BLZF1; BARD1; NUDC; ATM; DHFR; SETA; HUS1; NIPBLA; ORC6L
p signaling pathway
CD82B; CCNE1; TP53; EI24; Casp3; SIAH1A; RPRM; CCND3; BAX; PERP
PIK-Akt signaling pathway
IFNA12; PDGFB; VEGFA; GNG2; CCNE1; THBS1; VWF; HGF; TNXB; PIK3R5
Apoptosis
CASP6; HMGB2; IRF2; AKT2L; GZMF; HIST1H1A; BCL2L11; CAPN2A; LMNB1; AKT2
Wnt signaling pathway
RAC2; DVL3A; PPP3CB; PPP3R1B; BTRC; CSNK2A2A; DAAM2; DKK1; LRP6; WNT10B
Neurotrophin signaling pathway
RAP1B; CALM2; MAP2K2; ARHGDIG; SHC3; BDNF; NGF; NFKBIA; PTPN11; PSEN2
Thyroid hormone signaling pathway
MED13; MED4; GATA4; NCOA3; NOTCH4; SRC; MED12; ATP1B3; ATP1B1; ATP2A2
Amyotrophic lateral sclerosis (ALS)
DERL1; PRPH; MAP2K3; MAP3K5; CAT; TP53; CYCS; GRIN2A; MAPK14; APAF1
Huntingtons disease
SDHA; NRF1; SOD1; COX6A1; GNAQ; NDUFS4; ATP5G3; GRIN2B; HAP1; NDUFA12
Hepatitis C
TBK1; MAPK8; PIK3CG; IFNA5; PPP2R2A; OSTN; CLDN8; IFNAR2; RNASEL; TP53
Hepatitis B
TLR3; FOS; SRC; CREB5; NFATC3; TBK1; IFNA4; AKT1; AKT2; TLR2
Measles
IFNA2; IFNA6; IFNA13; TLR7; HSPA8; IL2RG; CD209B; TBK1; OAS3; IFNA12
HTLV-I infection
IL15; CDC16; PDGFA; WNT8B; WNT1; MAP2K4; KRAS; TRP53INP1; NFYB; APC
Herpes simplex infection
IFNA7; STAT1B; GLTSCR2; NXF2; MHC1UXA2; BMA2; IFIH1; STAT1A; IFNA6; HNRPK
Epstein-Barr virus infection
PSMD2; HDAC1; MAP2K4; GTF2E1; POLR2A; ICAM1; POLR2J2; PIK3CB; SHFM1; PSMC2
Pathways in cancer
FGF19; PIK3R3; TP53; RASSF5; BIRC8; FGF1; PIAS2; LPAR2; PIK3CD; PPARG
Transcriptional misregulation in cancer
LDB1; IGFBP3; RXRA; ETV6; ELK4; SPI1; IL1R2; MAF; RUNX1T1; PAX8
Viral carcinogenesis
TBP; GTF2A2; HIST1H4B; KAT2B; SNW1; POLB; UBR4; HIST1H2BL; HLA-A; HIST1H4A
Proteoglycans in cancer
PXN; MAP2K1; HGF; MMP9; TGFB1; FAS; TRP53; FN1; PLCG2; BRAF
MicroRNAs in cancer
PIK3CA; MAPK7; FSCN1; BRCA1; PLCG1; RASSF1; DNMT3A; ST14; IGF2BP1; HDAC1
Colorectal cancer
CYCS; AXIN1; CCND1; RAC2; MSH2; LEF1; TP53; PIK3R5; AKT1; PIK3CD
Pancreatic cancer
PIK3R5; BRAF; RAC2; TGFB3; TP53; RAF1; NFKB1; CCND1; IKBKB; MAPK10
Endometrial cancer
PIK3CB; CASP9; FOXO3; SOS1; PIK3R3; MAP2K2; KRAS; PDPK1; MLH1; BRAF
Glioma
CCND1; AKT1; NRAS; PRKCG; PIK3R3; PIK3R2; CALM3; CAMK2B; SHC1; PIK3CB
Prostate cancer
PDGFRA; PDPK1; IGF1; HSP90AB1; INS2; PIK3R2; PIK3R3; AKT2; PIK3CD; CCNE2
Thyroid cancer
PPARG; MAP2K1; CDH1; TRP53; MAPK3; TCF7; LEF1; TFG; TCF7L2; NTRK1
Basal cell carcinoma
WNT11; WNT3A; GLI2; PTCH1; GLI3; FZD8; AXIN1; FZD9; SETD6; WNT16
Melanoma
BRAF; IGF1R; TP53; HRAS; FGF5; FGF1; FGF22; PIK3CA; RAF1; FGF12
Bladder cancer
RAF1; CDKN2A; MAP2K2; MAP2K1; TRP53; E2F2; MMP9; RASSF1; RB1; UPK3A
Chronic myeloid leukemia
RAF1; KRAS; BRAF; CCND1; PIK3CB; TGFB1; PIK3CA; PIK3R5; SMAD3; MAPK1
Small cell lung cancer
RXRG; LAMA2; XIAP; CCND1; TRAF6; RARB; CCNE1; BIRC2; LAMB4; TRP53
Non-small cell lung cancer
RXRB; CCND1; MAPK1; ARAF; PIK3R2; STK4; TP53; RASSF5; NRAS; RB1
Central carbon metabolism in cancer
PDGFRA; MAP2K2; PKM; FGFR3; MET; HIF1A; SLC7A5; PIK3CB; PIK3R3; SIRT6

Protein Function

TP53 has several biochemical functions, for example, ATP binding, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP53 itself. We selected most functions TP53 had, and list some proteins which have the same functions with TP53. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RUVBL2; ORC4; DDX43; PC; ABCC3; PEO1; CHD7; AACS; NLRP9B; UBE2B
Function DNA binding
Related Protein ZNF10; NR1D2A; ARID5B; ZNF800; ETV5B; POU3F3B; SIX3A; ZNF530; FOXP2; UNCX4.1
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein TP53; H3F3A; SOX11; SMAD5; H2AFZ; SP3; RBPJ; ZNF277; PAX6; NLRC5
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein FOXQ1A; SIM1A; FOXQ1B; FOXE3; LMO2; FOXO4; ETS1; FOXG1C; NFIB; TFDP1B
Function RNA polymerase II transcription factor binding
Related Protein GATA4; DHX9; MKX; TBX20; TRPS1; GATA2B; TBX3; SPI1; GATA5; ATF4
Function chaperone binding
Related Protein TIMM9; Alb; TG; TBCE; AHSA1L; DNAJC10; BAG1; SOD1; SERPINA7; DNAJB7
Function chromatin binding
Related Protein LOXL2; FOXO1; CBX7; SKI; PHF21A; PRKCB; CBX4; ASH1L; CSNK2B; MSGN1
Function copper ion binding
Related Protein LOXL2A; TRP53; F5; SOD3A; SNAI3; LOXL4; AOC3; TYR; TYRP1; COMMD1
Function core promoter sequence-specific DNA binding
Related Protein ATF4; SOX1; THRAP3; CREM; CHD2; REST; SIRT1; MEOX1; NFYA; GATA3
Function damaged DNA binding
Related Protein TRPC2; NEIL3; RPA3; RPS3; RAD1; RPA2; FEN1; REV1; RAD23B; RAD23AB
Function double-stranded DNA binding
Related Protein MTERFD2; MEN1; NEIL3; XRCC5; TRP63; ERCC5; GTF2H4; NTHL1; RBMS1; PYDC3
Function enzyme binding
Related Protein HSPA1A; DVL1; PLSCR1; BCL10; CUTA; APOA5; TRP53; HAND2; HDAC1; SRC
Function histone acetyltransferase binding
Related Protein HIF1A; PAX6; CITED2; MEF2A; GLI3; CEBPB; EID1; TP53; ZBTB7A; TAF7L
Function histone deacetylase regulator activity
Related Protein MAPK8; TRP53; NCOR1; TP53
Function identical protein binding
Related Protein DYNLT1C; ACADM; NUFIP1; SERPINA1; DESI1; MCM6; IFI203; MCIN; CLDN14; UBE2G2
Function p53 binding
Related Protein CHD8; ZMAT3; TP63; SIRT1; SMARCB1; RNF34; NUAK1; STK11; CDKN2AIP; AXIN1
Function protease binding
Related Protein MBP; C10orf2; CSTA; PEO1; RYR1; FAP; INS1; SERPINB4; PANX1; FN1
Function protein N-terminus binding
Related Protein VPS25; RASSF1; DCTN4; MYO7A; MORF4L1; TAF11; SLA2; SCFD1; DAXX; ERCC4
Function protein binding
Related Protein TRIM54; CALCOCO1; SMC2; AP4B1; HGS; RORA; WTIP; EXOC8; SIN3B; ZRSR2
Function protein heterodimerization activity
Related Protein NR4A2; SMC1A; NAE1; JAM2; ATF1; TYRO3; BAX; HIST2H2BE; CHRNA5; HIST1H2BA
Function protein kinase binding
Related Protein EMP2; CNTLN; SHC1; USP37; PFKFB2; ADAM10; PRKAG3; PDGFRB; CCNE2; CDK5RAP1
Function protein phosphatase 2A binding
Related Protein PPME1; STRN; PTPN1; MAPT; PPP2R2A; SMG7; RPS6KB1; PPP2R4; HMGCR; GRIN3A
Function protein phosphatase binding
Related Protein PIK3R2; DLG3; VCAN; STAT3; PPP1R3C; RPA2; KCNN4; MET; KAT2A; TRP53
Function protein self-association
Related Protein AGA; CTSC; MALT1; PROSAPIP1; PTH1R; CBR2; ACVR2A; SLC9A3R1; PCSK9; L1CAM
Function receptor tyrosine kinase binding
Related Protein PITPNM3; SHC4; CPNE3; ANXA5; ZFP259; ARHGEF16; FNTA; DOCK4; TOB1; TRP53
Function sequence-specific DNA binding
Related Protein NFIL3-3; IRF4; DLX3B; ENG1B; MNX2B; FOXO6; ZNF232; MSXD; NR1H3; HOXA1A
Function transcription factor activity, sequence-specific DNA binding
Related Protein HIRA; KAT7A; ZNF518A; NFAT5; ZNF397; ZNF436; MAFA; Ar; NR3C1; ATF6
Function transcription factor binding
Related Protein TAF7; IGHMBP2; HMGA2; Trl; MYBBP1A; TBL1X; WWP2; HEY1; PPID; TRERF1
Function transcription regulatory region DNA binding
Related Protein GATA3; RCOR1; ATF5; FOXA1; ETV5; TP63; WNT1; HINFP; IKZF1; ZFP161
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CAMTA1; CTCFL; RELA; ETV1; CDX4; FOXJ2; TFAP2B; NOBOX; HLTF; AKNA
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein NR1I2; MAFK; SOX17; SOHLH2; STAG1; GATA4; CREB3L3; PKNOX1; NKX2-5; HOXD8
Function ubiquitin protein ligase binding
Related Protein UBE2B; SUMO1; HSPA5; HSPA9; PDE4D; IKBKE; CUL9; CUL4A; TCP1; LYN
Function zinc ion binding
Related Protein JHDM1D; RYBPB; BRF2; NR4A2A; MT2A; CSRP3; RNF145B; ZCWPW1; ZNF257; CYLD

Interacting Protein

TP53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP53 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP53.
MDM2

TP53 Related Articles

Sadahira, Y; Sugihara, T; et al. WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome. VIRCHOWS ARCHIV 466:343-350(2015).
Fuentes-Raspall, MJ; Caragol, I; et al. Apoptosis for prediction of radiotherapy late toxicity: lymphocyte subset sensitivity and potential effect of TP53 Arg72Pro polymorphism. APOPTOSIS 20:371-382(2015).