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Active Recombinant Human CD70 protein, His-tagged

Cat.No. : CD70-196H
Product Overview : Recombinant Human CD70 protein(P32970-1)(Leu50-Pro193) is expressed from Expi293 with His tag at the N-terminal.
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Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.
Bio-activity : Immobilized Human CD27 Ligand (Trimer) at 2μg/ml (100μl/Well) on the plate. Dose response curve for Human CD27, hFc Tag with the EC50 of 63.8ng/ml determined by ELISA.
Molecular Mass : The protein has a predicted MW of 51.8 kDa. Due to glycosylation, the protein migrates to 62-65 kDa based on Tris-Bis PAGE result.
Protein length : Leu50-Pro193
Endotoxin : Less than 1EU per μg by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC
Storage : -20 to -80°C for 12 months as supplied from date of receipt.
-20 to -80°C for 3-6 months in unopened state after reconstitution.
4-8℃ for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles.
Reconstitution : Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended (usually we use 1mg/ml solution for lyophilization). Dissolve the lyophilized protein in distilled water.
Gene Name : CD70 CD70 molecule [ Homo sapiens ]
Official Symbol : CD70
Synonyms : CD70; CD70 molecule; CD27LG, TNFSF7, tumor necrosis factor (ligand) superfamily, member 7; CD70 antigen; CD27L; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7; CD27LG; TNFSF7;
Gene ID : 970
mRNA Refseq : NM_001252
Protein Refseq : NP_001243
MIM : 602840
UniProt ID : P32970

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are some potential CD70-targeted therapies for cancer? 04/29/2023

Antibodies, antibody-drug conjugates, and chimeric antigen receptor (CAR) T-cell therapies are being developed to target CD70 in cancer.

How can CD70-targeted therapies improve cancer treatment outcomes? 05/03/2022

CD70-targeted therapies can enhance the body's immune response against cancer cells and potentially lead to more effective treatments.

In which hematological malignancies is CD70 expression frequently observed? 04/08/2021

CD70 expression is often observed in Hodgkin's lymphoma and certain types of T-cell lymphomas.

Are there any challenges in developing CD70-targeted therapies for cancer? 03/14/2020

Challenges include potential toxicities and finding the right balance to target CD70 effectively without harming normal immune functions.

Are there clinical trials involving CD70-targeted therapies for cancer treatment? 11/14/2018

Yes, there are ongoing clinical trials exploring CD70-targeted therapies for various cancer types.

Customer Reviews (3)

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05/31/2021

    Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.

    04/23/2019

      the manufacturer's support is crucial for researchers using CD70 protein in trials.

      03/07/2017

        These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.

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