Recombinant Hamster Cxcl13 Protein, His-tagged

• Cat.No.: Cxcl13-2772H
• Product Overview: Recombinant Hamster Cxcl13 Protein (Ile22-Ala111) with N-His tag was expressed in E. coli.

Specification

• Description: B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles.
• Source: E. coli
• Species: Hamster
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 13.7 kDa
  Accurate Molecular Mass: 16 kDa
• Protein length: Ile22-Ala111
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Cxcl13 C-X-C motif chemokine ligand 13 [ Cricetulus griseus (Chinese hamster) ]
• Official Symbol: Cxcl13
• Synonyms: Cxcl13; C-X-C motif chemokine ligand 13; C-X-C motif chemokine 13; c-X-C motif chemokine 13-like protein; chemokine (C-X-C motif) ligand 13; SCYB13; BLC; BCA1; BLR1L; ANGIE; ANGIE2; Chemokine(C-X-C-Motif)ligand 13; Small Inducible Cytokine B Subfamily(Cys-X-Cys Motif)Member 13
• Gene ID: 100773550
• mRNA Refseq: XM_003512697
• Protein Refseq: XP_003512745

Reviews

07/10/2021

Stability of CXCL13 was very good during long-term storage, and its properties remained unchanged after prolonged storage, indicating its excellent storage stability.

06/21/2021

The broad storage conditions of proteins make the experimental process more stable and reliable, which provides strong support for scientific research.

08/14/2019

In the process of CXCL13 production, it can be seen that it pays great attention to purity and biological activity, which makes its product extremely reliable.

Q&As

Is the expression pattern of CXCL13 protein related to the clinical prognosis of specific diseases?

Expression pattern of CXCL13 protein may be related to the clinical prognosis of specific diseases, but the specific association needs further research and verification.

What are the expression characteristics of CXCL13 protein in immune cells?

The protein is mainly expressed in immune cells by activated dendritic cells, macrophages and inflammatory cells.

Is there a regulatory mechanism for CXCL13 protein expression during inflammation?

The expression of CXCL13 protein is regulated by a variety of signaling pathways, including NF-κB, AP-1, etc. Stimulation of inflammatory factors and cytokines may lead to upregulation of CXCL13 expression.

What is the role of CXCL13 protein in lymph node metastasis?

In lymph node metastasis, the CXCL13 protein promotes the localization and metastasis of cancer cells by attracting CXCR5-positive cancer cells or immune cells.

What are the implications of CXCL13 protein research for new drug development?

CXCL13 protein plays an important role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of CXCL13 protein will help the development of new drugs, such as targeted drugs targeting CXCL13 and its related signaling pathways, which may be applied to the treatment of related diseases.

What are the potential applications of CXCL13 protein in immunotherapy?

The CXCL13 protein is involved in immunomodulation, and its bound antibodies or specific receptor antagonists may contribute to the design and development of immunotherapy.