Active Recombinant Mouse Cxcl13 Protein

• Cat.No.: Cxcl13-149M
• Product Overview: Purified recombinant protein of Mouse chemokine (C-X-C motif) ligand 13 (Cxcl13) without tag was expressed in E.coli.

Specification

• Description: Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.
• Source: E. coli
• Species: Mouse
• Bio-activity: Determined by its ability to chemoattract murine B cells using a concentration of 10.0-100.0 ng/ml.
• Molecular Mass: 9.8 kDa
• AA Sequence: ILEAHYTNLKCRCSGVISTVVGLNI IDRIQVTPPGNGCPKTEVVIWTKMK KVICVNPRAKWLQRLLRHVQSKSLS STPQAPVSKRRAA
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
• Purity: >95%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Storage: Store at -80 centigrade.
• Storage Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2
• Reconstitution: Resuspend the protein in the desired concentration in proper buffer.

Gene Information

• Gene Name: Cxcl13 chemokine (C-X-C motif) ligand 13 [ Mus musculus (house mouse) ]
• Official Symbol: Cxcl13
• Synonyms: Cxcl13; chemokine (C-X-C motif) ligand 13; BLC; Angie; BCA-1; BLR1L; ANGIE2; Scyb13; 4631412M08Rik; C-X-C motif chemokine 13; B lymphocyte chemoattractant; CXC chemokine BLC; small inducible cytokine subfamily B (Cys-X-Cys), member 13; small-inducible cytokine B13
• Gene ID: 55985
• mRNA Refseq: NM_018866
• Protein Refseq: NP_061354
• UniProt ID: O55038

Reviews

07/10/2021

Stability of CXCL13 was very good during long-term storage, and its properties remained unchanged after prolonged storage, indicating its excellent storage stability.

06/21/2021

The broad storage conditions of proteins make the experimental process more stable and reliable, which provides strong support for scientific research.

08/14/2019

In the process of CXCL13 production, it can be seen that it pays great attention to purity and biological activity, which makes its product extremely reliable.

Q&As

Is the expression pattern of CXCL13 protein related to the clinical prognosis of specific diseases?

Expression pattern of CXCL13 protein may be related to the clinical prognosis of specific diseases, but the specific association needs further research and verification.

What are the expression characteristics of CXCL13 protein in immune cells?

The protein is mainly expressed in immune cells by activated dendritic cells, macrophages and inflammatory cells.

Is there a regulatory mechanism for CXCL13 protein expression during inflammation?

The expression of CXCL13 protein is regulated by a variety of signaling pathways, including NF-κB, AP-1, etc. Stimulation of inflammatory factors and cytokines may lead to upregulation of CXCL13 expression.

What is the role of CXCL13 protein in lymph node metastasis?

In lymph node metastasis, the CXCL13 protein promotes the localization and metastasis of cancer cells by attracting CXCR5-positive cancer cells or immune cells.

What are the implications of CXCL13 protein research for new drug development?

CXCL13 protein plays an important role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of CXCL13 protein will help the development of new drugs, such as targeted drugs targeting CXCL13 and its related signaling pathways, which may be applied to the treatment of related diseases.

What are the potential applications of CXCL13 protein in immunotherapy?

The CXCL13 protein is involved in immunomodulation, and its bound antibodies or specific receptor antagonists may contribute to the design and development of immunotherapy.