Active Recombinant Human CXCL13 Protein

Cat.No. : CXCL13-132H
Product Overview : Recombinant Human CXCL13 Protein without tag was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles.
Source : E.coli
Species : Human
Form : Sterile Filtered White lyophilized (freeze-dried) powder.
Bio-activity : Determined by its ability to chemoattract human B cells using a concentration range of 1-10 ng/mL corresponding to a Specific Activity of 100,000-1,000,000 IU/mg.
Molecular Mass : 10.3 kDa
Protein Length : 87 AA
AA Sequence : VLEVYYTSLRCRCVQESSVFIPRRF IDRIQILPRGNGCPRKEIIVWKKNK SIVCVDPQAEWIQRMMEVLRKRSSS TLPVPVFKRKIP.
Purity : Greater than 97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Notes : Our products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Storage : Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution BCA1 should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Concentration : 0.5 mg/mL
Storage Buffer : 20mM PBS & 150mM NaCl pH7.4.
Shipping : Room temperature.
Gene Name : CXCL13 C-X-C motif chemokine ligand 13 [ Homo sapiens (human) ]
Official Symbol : CXCL13
Synonyms : CXCL13; C-X-C motif chemokine ligand 13; BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13; C-X-C motif chemokine 13; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); B-lymphocyte chemoattractant; CXC chemokine BLC; b cell-attracting chemokine 1; b lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); small-inducible cytokine B13
Gene ID : 10563
mRNA Refseq : NM_006419
Protein Refseq : NP_006410
MIM : 605149
UniProt ID : O43927

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is the expression pattern of CXCL13 protein related to the clinical prognosis of specific diseases? 11/28/2019

Expression pattern of CXCL13 protein may be related to the clinical prognosis of specific diseases, but the specific association needs further research and verification.

What are the expression characteristics of CXCL13 protein in immune cells? 10/23/2019

The protein is mainly expressed in immune cells by activated dendritic cells, macrophages and inflammatory cells.

Is there a regulatory mechanism for CXCL13 protein expression during inflammation? 04/12/2019

The expression of CXCL13 protein is regulated by a variety of signaling pathways, including NF-κB, AP-1, etc. Stimulation of inflammatory factors and cytokines may lead to upregulation of CXCL13 expression.

What is the role of CXCL13 protein in lymph node metastasis? 04/11/2019

In lymph node metastasis, the CXCL13 protein promotes the localization and metastasis of cancer cells by attracting CXCR5-positive cancer cells or immune cells.

What are the implications of CXCL13 protein research for new drug development? 02/27/2019

CXCL13 protein plays an important role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of CXCL13 protein will help the development of new drugs, such as targeted drugs targeting CXCL13 and its related signaling pathways, which may be applied to the treatment of related diseases.

What are the potential applications of CXCL13 protein in immunotherapy? 02/17/2019

The CXCL13 protein is involved in immunomodulation, and its bound antibodies or specific receptor antagonists may contribute to the design and development of immunotherapy.

Customer Reviews (3)

Write a review
Reviews
07/10/2021

    Stability of CXCL13 was very good during long-term storage, and its properties remained unchanged after prolonged storage, indicating its excellent storage stability.

    06/21/2021

      The broad storage conditions of proteins make the experimental process more stable and reliable, which provides strong support for scientific research.

      08/14/2019

        In the process of CXCL13 production, it can be seen that it pays great attention to purity and biological activity, which makes its product extremely reliable.

        Ask a Question for All CXCL13 Products

        Required fields are marked with *

        My Review for All CXCL13 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends