Recombinant Human FAP
Cat.No. : | FAP-28896TH |
Product Overview : | Recombinant fragment of Human Fibroblast activation protein, alpha (amino acids 559-760) with proprietary tag; 202aa (without tag), 48kDa. |
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Description : | The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. |
Protein length : | 202 amino acids |
Molecular Weight : | 48.000kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Fibroblast specific. |
Form : | Liquid |
Storage buffer : | pH: 7.50Constituents:20% Glycerol, Tris acetate, 0.03% EDTA |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequences of amino acids : | SYLASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD |
Sequence Similarities : | Belongs to the peptidase S9B family. |
Gene Name : | FAP fibroblast activation protein, alpha [ Homo sapiens ] |
Official Symbol : | FAP |
Synonyms : | FAP; fibroblast activation protein, alpha; seprase; DPPIV; |
Gene ID : | 2191 |
mRNA Refseq : | NM_004460 |
Protein Refseq : | NP_004451 |
MIM : | 600403 |
Uniprot ID : | Q12884 |
Chromosome Location : | 2q23 |
Function : | dipeptidyl-peptidase activity; metalloendopeptidase activity; peptidase activity; protein binding; protein dimerization activity; |
Products Types
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◆ Lysates | ||
FAP-1881HCL | Recombinant Human FAP cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1729 | FAP Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFAP can suppress the immune response by modulating the activity of certain immune cells, creating an immunosuppressive tumor microenvironment.
High levels of FAP expression in tumors have been associated with poor prognosis, making it a potential prognostic marker for certain cancers.
Yes, several clinical trials are investigating the safety and efficacy of FAP-targeted therapies in various cancer types.
FAP-targeted therapies are being explored for conditions such as fibrotic diseases and rheumatoid arthritis, extending its potential clinical applications.
Molecular imaging techniques, such as positron emission tomography (PET), can be employed to visualize FAP expression in tumors noninvasively.
Customer Reviews (3)
Write a reviewIt enables accurate detection and quantification of FAP protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.
FAP protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.
FAP protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.
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