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Recombinant Human fibroblast activation protein, alpha, GST-tagged

Cat.No. : FAP-1461H
Product Overview : Seprase Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 203 amino acids (559-761 a.a.) and having a total Mw of 48kDa. Seprase is fused to a GST tag and is purified by proprietary chromatographic techniques.
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Cat. No. : FAP-1461H
Description : Seprase is a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. Seprase is a homodimeric integral membrane gelatinase, which is part of the serine protease family. Seprase is expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. Seprase protein has a role in the control of fibroblast growth or epithelial-mesenchymal interactions throughout development, tissue repair, and epithelial carcinogenesis.
Source : Human
Host : Escherichia Coli
Form : Seprase is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Physical Appearance : Sterile Filtered clear solution.
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name : FAP fibroblast activation protein, alpha [ Homo sapiens ]
Official Symbol : FAP
Synonyms : FAP; fibroblast activation protein, alpha; FAPA; DPPIV; DKFZp686G13158; seprase; OTTHUMP00000204566; OTTHUMP00000207304; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase
Gene ID : 2191
mRNA Refseq : NM_004460
Protein Refseq : NP_004451
MIM : 600403
UniProt ID : Q12884
Chromosome Location : 2q23
Function : metalloendopeptidase activity; metalloendopeptidase activity; peptidase activity; protein binding; protein homodimerization activity; serine-type endopeptidase activity; serine-type endopeptidase activity; serine-type peptidase activity; contributes_to serine-type peptidase activity; serine-type peptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does FAP contribute to immunosuppression in the tumor microenvironment? 04/18/2023

FAP can suppress the immune response by modulating the activity of certain immune cells, creating an immunosuppressive tumor microenvironment.

How can FAP expression be used as a prognostic marker in cancer patients? 02/03/2023

High levels of FAP expression in tumors have been associated with poor prognosis, making it a potential prognostic marker for certain cancers.

Are there ongoing clinical trials exploring FAP-targeted therapies? 05/04/2021

Yes, several clinical trials are investigating the safety and efficacy of FAP-targeted therapies in various cancer types.

Can FAP be utilized as a therapeutic target beyond cancer treatment? 11/19/2020

FAP-targeted therapies are being explored for conditions such as fibrotic diseases and rheumatoid arthritis, extending its potential clinical applications.

How is imaging technology utilized to detect FAP expression in tumors? 09/17/2018

Molecular imaging techniques, such as positron emission tomography (PET), can be employed to visualize FAP expression in tumors noninvasively.

Customer Reviews (3)

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Reviews
08/11/2020

    It enables accurate detection and quantification of FAP protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.

    05/04/2020

      FAP protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.

      01/02/2019

        FAP protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.

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