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Recombinant Cynomolgus GPC3 protein, Fc-tagged
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Cat.No. : | GPC3-50C Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Cynomolgus GPC3 protein (Gln25-His559), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
Description : | Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3/GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. |
Source : | HEK293 |
Species : | Cynomolgus |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 87.5 kDa. The protein migrates as 44 kDa, 60 kDa and 100-120 kDa on a SDS-PAGE gel under reducing (R) condition due to naturally cleavage. |
Protein length : | 535 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >90% GPC3 and 2-8% human IgG1 Fc fragment as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
SDS-PAGE of GPC3-50C : |
![]() Cynomolgus Glypican 3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%. |
Bioactivity-ELISA of GPC3-50C : |
![]() Immobilized Human FGF basic, Tag Free at 2 μg/mL (100 μL/well) can bind Cynomolgus Glypican 3, Fc Tag with a linear range of 1-31 ng/mL (QC tested). ![]() Immobilized Cynomolgus Glypican 3, Fc Tag at 0.5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GPC3 Antibody, Human IgG1 with a linear range of 0.2-3 ng/mL (Routinely tested). |
Gene Name : | GPC3 |
Official Symbol : | GPC3 |
Synonyms : | GPC3; glypican 3; glypican-3; OCI-5 |
Gene ID : | 102137748 |
mRNA Refseq : | XM_005594608.2 |
Protein Refseq : | XP_005594665.1 |
UniProt ID : | A0A2K5VKD5 |
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