Recombinant Human HGF Protein

• Cat.No.: HGF-4726H
• Product Overview: Human HGF (NP_000592.3, 32 a.a. - 494 a.a.) partial recombinant protein expressed in Escherichia coli.

Specification

• Description: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq
• Source: E. coli
• Species: Human
• Form: Liquid
• AA Sequence: QRKRRNTIHEFKKSAKTTLIKIDPA LKIKTKKVNTADQCANRCTRNKGLP FTCKAFVFDKARKQCLWFPFNSMSS GVKKEFGHEFDLYENKDYIRNCIIG KGRSYKGTVSITKSGIKCQPWSSMI PHEHSFLPSSYRGKDLQENYCRNPR GEEGGPWCFTSNPEVRYEVCDIPQC SEVECMTCNGESYRGLMDHTESGKI CQRWDHQTPHRHKFLPERYPDKGFD DNYCRNPDGQPRPWCYTLDPHTRWE YCAIKTCADNTMNDTDVPLETTECI QGQGEGYRGTVNTIWNGIPCQRWDS QYPHEHDMTPENFKCKDLRENYCRN PDGSESPWCFTTDPNIRVGYCSQIP NCDMSHGQDCYRGNGKNYMGNLSQT RSGLTCSMWDKNMEDLHRHIFWEPD ASKLNENYCRNPDDDAHGPWCYTGN PLIPWDYCPISRCEGDTTPTIVNLD HPVISCAKTKQLR
• Purity: > 95% by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Store at -2 centigrade. For long term storage store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: In PBS (50% glycerol)

Gene Information

• Gene Name: HGF hepatocyte growth factor (hepapoietin A; scatter factor) [ Homo sapiens ]
• Official Symbol: HGF
• Synonyms: HGF; hepatocyte growth factor (hepapoietin A; scatter factor); deafness, autosomal recessive 39 , DFNB39; hepatocyte growth factor; F TCF; fibroblast derived tumor cytotoxic factor; hepatopoietin A; HGFB; HPTA; lung fibroblast derived mitogen; scatter factor; SF; hepatopoeitin-A; hepatopoietin-A; lung fibroblast-derived mitogen; fibroblast-derived tumor cytotoxic factor; F-TCF; DFNB39
• Gene ID: 3082
• mRNA Refseq: NM_000601
• Protein Refseq: NP_000592
• MIM: 142409
• UniProt ID: P14210