| Description : |
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Bio-activity : |
Cell treatment |
| Molecular Mass : |
79.6 kDa |
| AA Sequence : |
MWVTKLLPALLLQHVLLHLLLLPIA IPYAEGQRKRRNTIHEFKKSAKTTL IKIDPALKIKTKKVNTADQC ANRCTRNKGLPFTCKAFVFDKARKQ CLWFPFNSMSSGVKKEFGHEFDLYE NKDYIRNCIIGKGRSYKGTV SITKSGIKCQPWSSMIPHEHSFLPS SYRGKDLQENYCRNPRGEEGGPWCF TSNPEVRYEVCDIPQCSEVE CMTCNGESYRGLMDHTESGKICQRW DHQTPHRHKFLPERYPDKGFDDNYC RNPDGQPRPWCYTLDPHTRW EYCAIKTCADNTMNDTDVPLETTEC IQGQGEGYRGTVNTIWNGIPCQRWD SQYPHEHDMTPENFKCKDLR ENYCRNPDGSESPWCFTTDPNIRVG YCSQIPNCDMSHGQDCYRGNGKNYM GNLSQTRSGLTCSMWDKNME DLHRHIFWEPDASKLNENYCRNPDD DAHGPWCYTGNPLIPWDYCPISRCE GDTTPTIVNLDHPVISCAKT KQLRVVNGIPTRTNIGWMVSLRYRN KHICGGSLIKESWVLTARQCFPSRD LKDYEAWLGIHDVHGRGDEK CKQVLNVSQLVYGPEGSDLVLMKLA RPAVLDDFVSTIDLPNYGCTIPEKT SCSVYGWGYTGLINYDGLLR VAHLYIMGNEKCSQHHRGKVTLNES EICAGAEKIGSGPCEGDYGGPLVCE QHKMRMVLGVIVPGRGCAIP
NRPGIFVRVAYYAKWIHKIILTYKV PQSTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protease, Transmembrane |
| Protein Pathways : |
Cytokine-cytokine receptor interaction, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma |
