IL10RB
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Official Full Name
interleukin 10 receptor, beta
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Background
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. -
Synonyms
IL10RB; interleukin 10 receptor, beta; CRFB4, D21S58, D21S66; interleukin-10 receptor subunit beta; CDW210B; CRF2 4; IL 10R2; Cd210; CRF2-4; CRFB4; Cytokine receptor class II; Cytokine receptor class II CRF2 4; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; Cytokine receptor family II member 4; D21S58; D21S66; I10R2_HUMAN; IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; IL-10R2; IL-10RB; IL10R2; Interleukin 10 receptor beta; Interleukin-10 receptor subunit 2; OTTHUMP00000067678; cytokine receptor class-II CRF2-4; cytokine receptor fami;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL10RB Related Gene Family
- IL10RB Related Research Area
- IL10RB Related Signal Pathway
IL10RB involved in several pathways and played different roles in them. We selected most pathways IL10RB participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL10RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | Ccl9;Ccl27a;PDGFRB;IL-8;IL13RA1;CXCL2;EPOR;IL20RA;IL11 |
| Epstein-Barr virus infection | HDAC2;IRF3;NFKB1;SND1;PSMC2;PSMC4;SFPI1;CSNK2A2;POLR2L |
| Jak-STAT signaling pathway | IFNA5;IL4R;IL6R;PRL;IFNB1;FHL1B;IL13RA2;HRASA;IL22RA1 |
| Toxoplasmosis | LAMC2;MAPK1;IFNGR2;LDLR;ITGA6;IKBKG;MAP2K3;STAT1;PIK3R1 |
| Tuberculosis | HLA-DMA;ATP6V0D2;CD209A;RAB7A;RAF1;NOS2;LAMP1;MAPK12;SPHK2 |
| Type III interferon signaling | IRX1;IL10RB;IL28RA |
IL10RB has several biochemical functions, for example, contributes_to interleukin-10 receptor activity, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL10RB itself. We selected most functions IL10RB had, and list some proteins which have the same functions with IL10RB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to interleukin-10 receptor activity | |
| protein binding | KLHL35;GREM1;ZNF205;SLC8A1;CKS1B;RAP1B;HIF1AN;SUMO3;CRY2 |
| receptor activity | ITGB8;CLEC4E;NRXN3;GRIA2A;NLGN4X;VMN1R49;EXTL3;AMFR;NOTCH4 |
IL10RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL10RB here. Most of them are supplied by our site. Hope this information will be useful for your research of IL10RB.
- Q&As
- Reviews
Q&As (10)
Ask a questionMass spectrometry-based interactomics identifies proteins interacting with IL10RB.
NMR spectroscopy helps understand dynamic interactions and structural shifts in IL10RB upon binding.
Proximity labeling and quantitative proteomics show IL10RB's changing protein network with IL-10.
Techniques like surface plasmon resonance and isothermal titration calorimetry measure IL10RB-IL-10 binding strength and kinetics.
Flow cytometry and single-cell transcriptomics reveal IL10RB's expression diversity in cells and immune subsets.
Mutagenesis and alanine scanning pinpoint amino acids essential for IL10RB's binding to IL-10.
CRISPR-edited cells and knockout models explore IL10RB's signaling after IL-10 binding.
X-ray crystallography and cryo-electron microscopy provide structural insights into IL10RB's changes upon IL-10 interaction.
Genome-wide CRISPR screening uncovers genes affecting IL10RB expression and function.
Co-immunoprecipitation and FRET study protein complexes involving IL10RB and IL-10.
Customer Reviews (3)
Write a reviewReliable in co-immunoprecipitation. -
High specificity. -
Effective in signaling pathways. -
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