• Official Full Name

    interleukin 10 receptor, beta

  • Background

    The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.
  • Synonyms

    IL10RB; interleukin 10 receptor, beta; CRFB4, D21S58, D21S66; interleukin-10 receptor subunit beta; CDW210B; CRF2 4; IL 10R2; Cd210; CRF2-4; CRFB4; Cytokine receptor class II; Cytokine receptor class II CRF2 4; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; Cytokine receptor family II member 4; D21S58; D21S66; I10R2_HUMAN; IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; IL-10R2; IL-10RB; IL10R2; Interleukin 10 receptor beta; Interleukin-10 receptor subunit 2; OTTHUMP00000067678; cytokine receptor class-II CRF2-4; cytokine receptor fami;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc
    • Fc|His
    • hFc
    • His
    • His (Fc)
    • Avi
    • His|HIgG
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken IL10RB-6420C Recombinant Chicken IL10RB Mammalian Cell His
    Human IL10RB-1647H Recombinant Human Interleukin 10 Receptor, Beta Mammalian cells N/A
    Human IL10RB-2677HCL Recombinant Human IL10RB cell lysate Human Cell N/A
    Human IL10RB-176H Recombinant Human IL10RB, Fc-His tagged Human Cell Fc/His
    Human IL10RB-14142H Recombinant Human IL10RB, His-tagged E.coli His
    Human IL10RB-217H Recombinant Human IL10RB Protein, hIgG-His-tagged Insect Cell His/HIgG
    Human IL10RB-202H Active Recombinant Human IL10RB, HIgG1 Fc-tagged CHO Fc
    Human IL10RB-581H Recombinant Human IL10RB protein, His-tagged E.coli His
    Human IL10RB-201H Active Recombinant Human IL10RB, MIgG2a Fc-tagged CHO Fc
    Human IL10RB-4431H Recombinant Human IL10RB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL10RB-2251H ecombinant Human IL10RB, His-tagged HEK293 His
    Human IL10RB-4431H-B Recombinant Human IL10RB Protein Pre-coupled Magnetic Beads HEK293
    Human IL10RB-952H Recombinant Human IL10RB Protein, Fc-tagged HEK293 Fc
    Human IL10RB-1211H Recombinant Human IL10RB Protein (Leu87-Ala243), N-His tagged E.coli N-His
    Mouse IL10RB-1795MCL Recombinant Mouse IL10RB cell lysate Human Cell N/A
    Mouse Il10rb-1732M Recombinant Mouse Il10rb protein, His-tagged E.coli His
    Mouse Il10rb-5180M Recombinant Mouse Il10rb protein, hFc-tagged HEK293 hFc
    Mouse Il10rb-5181M Recombinant Mouse Il10rb, His tagged Human Cell His
    Rat Il10rb-8733R Recombinant Rat Il10rb, Fc tagged Human Cell Fc
    Rat IL10RB-1371RCL Recombinant Rat IL10RB cell lysate Human Cell N/A
    Zebrafish IL10RB-3442Z Recombinant Zebrafish IL10RB Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL10RB Related Gene Family
    • IL10RB Related Research Area
    • IL10RB Related Signal Pathway

    IL10RB involved in several pathways and played different roles in them. We selected most pathways IL10RB participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL10RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionCcl9;Ccl27a;PDGFRB;IL-8;IL13RA1;CXCL2;EPOR;IL20RA;IL11
    Epstein-Barr virus infectionHDAC2;IRF3;NFKB1;SND1;PSMC2;PSMC4;SFPI1;CSNK2A2;POLR2L
    Jak-STAT signaling pathwayIFNA5;IL4R;IL6R;PRL;IFNB1;FHL1B;IL13RA2;HRASA;IL22RA1
    Type III interferon signalingIRX1;IL10RB;IL28RA

    IL10RB has several biochemical functions, for example, contributes_to interleukin-10 receptor activity, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL10RB itself. We selected most functions IL10RB had, and list some proteins which have the same functions with IL10RB. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to interleukin-10 receptor activity
    protein bindingKLHL35;GREM1;ZNF205;SLC8A1;CKS1B;RAP1B;HIF1AN;SUMO3;CRY2

    IL10RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL10RB here. Most of them are supplied by our site. Hope this information will be useful for your research of IL10RB.

    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    Can you explain the role of mass spectrometry-based interactomics in identifying IL10RB-interacting proteins? 12/17/2022

    Mass spectrometry-based interactomics identifies proteins interacting with IL10RB.

    How does NMR spectroscopy help in understanding dynamic interactions and structural changes in IL10RB upon ligand binding? 11/29/2022

    NMR spectroscopy helps understand dynamic interactions and structural shifts in IL10RB upon binding.

    How do proximity labeling and quantitative proteomics reveal changes in IL10RB's protein network upon IL-10 stimulation? 02/12/2022

    Proximity labeling and quantitative proteomics show IL10RB's changing protein network with IL-10.

    How do techniques like surface plasmon resonance and isothermal titration calorimetry contribute to studying IL10RB-IL-10 binding kinetics? 11/09/2020

    Techniques like surface plasmon resonance and isothermal titration calorimetry measure IL10RB-IL-10 binding strength and kinetics.

    What insights do flow cytometry and single-cell transcriptomics provide about IL10RB's expression across cell types and immune subsets? 03/22/2020

    Flow cytometry and single-cell transcriptomics reveal IL10RB's expression diversity in cells and immune subsets.

    Could you explain how mutagenesis and alanine scanning identify critical amino acids in IL10RB's binding to IL-10? 05/11/2019

    Mutagenesis and alanine scanning pinpoint amino acids essential for IL10RB's binding to IL-10.

    How are CRISPR-edited cell lines and gene knockout models utilized to explore IL10RB's downstream signaling pathways after IL-10 binding? 03/18/2019

    CRISPR-edited cells and knockout models explore IL10RB's signaling after IL-10 binding.

    What methods are used to reveal structural changes in IL10RB upon interaction with IL-10, such as X-ray crystallography and cryo-electron microscopy? 10/21/2018

    X-ray crystallography and cryo-electron microscopy provide structural insights into IL10RB's changes upon IL-10 interaction.

    What does genome-wide CRISPR screening reveal about genes and pathways influencing IL10RB expression and function? 05/03/2018

    Genome-wide CRISPR screening uncovers genes affecting IL10RB expression and function.

    What experimental approaches, like co-immunoprecipitation and FRET, are used to study protein complexes involving IL10RB and IL-10? 04/14/2017

    Co-immunoprecipitation and FRET study protein complexes involving IL10RB and IL-10.

    Customer Reviews (3)

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      Reliable in co-immunoprecipitation. -


        High specificity. -


          Effective in signaling pathways. -

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