Recombinant Mouse interleukin 11
Cat.No. : | Il11-586M |
Product Overview : | RecombinantIl11 is a disulfide-linked monomer protein consisting of 179 amino acidresidue subunits, and migrates as an approximately 19 kDa protein undernon-reducing conditions and reducing conditions in SDS-PAGE, and waslyophilized from a 0.2 μm filtered PBS solution. |
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- Gene Information
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Cat. No. : | Il11-586M |
Description : | Il11 issecreted by bone marrow stromal cells (fibroblasts)and is produced also bya number of mesenchymal cells. The Il11receptor (alpha chain) utilizes gp130 as its signal transducer, which isalso a component of other cytokine receptors. The alpha chain of the Il11receptor has been identified independently as Etl2. Il11promotes primary and secondary immune responses in vitro and in vivo andmodulates antigen-specific antibody reactions. |
Source : | Mouse |
Host : | E. coli |
Purity : | >95%, asdetermined by SDS-PAGE and HPLC. |
Sequence : | MNCVCRLVLV VLSLWPDRVV APGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL |
Molecular Weight : | Native MouseIl11, generated by the proteolytic removal of the signal peptide andpropeptide, the molecule has a calculated molecular mass of approximately 19kDa. |
Biological Activity : | The ED(50) wasdetermined by the dose-dependent stimulation of the proliferation of murineT11 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg. |
Endotoxin : | Endotoxin contentwas assayed using a LAL gel clot method. Endotoxin level was found to be lessthan 0.1 ng/µg(1EU/µg). |
Reconstitution : | A quick spin of thevial followed by reconstitution in distilled water to a concentration notless than 0.1 mg/mL. This solution can then be diluted into other buffers. |
Storage : | The lyophilized protein is stable forat least 2 years from date of receipt at -20°C. Upon reconstitution, thiscytokine can be stored in working aliquots at 2°C - 8°C for one month, or at-20°C for six months, with a carrier protein without detectable loss ofactivity. Avoid repeated freeze/thaw cycles. |
OfficialSymbol : | Il11 |
Pathways : | Cytokine-cytokinereceptor interaction; Cytokines and Inflammatory Response (BioCarta); Hematopoieticcell lineage; Jak-STAT signaling pathway; Rheumatoid arthritis |
Gene Name : | Il11 interleukin 11 [ Mus musculus ] |
Synonyms : | Il11; interleukin11; IL-11; interleukin-11 |
Gene ID : | 16156 |
mRNA Refseq : | NM_008350 |
Protein Refseq : | NP_032376 |
UniProt ID : | P47873 |
Function : | cytokine activity; growthfactor activity; interleukin-11 receptor binding |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionTransgenic mice and knockdown models explore IL11's impact on tissue regeneration.
Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.
Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.
Proteomics identifies IL11-interacting proteins and potential cross-talk partners.
Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.
RNA sequencing uncovers IL11-induced gene expression changes across different cell types.
X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.
Confocal and super-resolution microscopy visualize IL11 localization in tissues.
Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.
CRISPR screening unveils genes and pathways influenced by IL11 signaling.
Customer Reviews (3)
Write a reviewPotent in bone regeneration models.
Suitable for cell culture.
High yield in expression.
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