Active Recombinant Mouse IL21R, Fc-tagged

• Cat.No.: IL21R-341M
• Product Overview: The extracellular domain of mouse IL-21R (aa 20-234) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.

Specification

• Description: Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common gamma chain (gammac) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth; IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).
• Source: CHO Cells
• Species: Mouse
• Tag: Fc
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Shows the biological function of the IL-21R moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
• Purity: ≥98% (SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Il21r interleukin 21 receptor [ Mus musculus ]
• Official Symbol: IL21R
• Synonyms: IL21R; interleukin 21 receptor; interleukin-21 receptor; NR8; IL-21R; LR-beta; IL-21 receptor; lymphocyte receptor beta; novel cytokine receptor 8; novel interleukin receptor; NILR
• Gene ID: 60504
• mRNA Refseq: NM_021887
• Protein Refseq: NP_068687
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: cytokine receptor activity; cytokine receptor activity; receptor activity; transmembrane signaling receptor activity