Recombinant Human IL21R Protein, Fc-tagged

Cat.No. : IL21R-326H
Product Overview : Recombinant human IL21R protein with Fc tag was expressed in HEK293.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized
Molecular Mass : 51.6 kDa
Protein Length : 538
AA Sequence : MPRGWAAPLLLLLLQGGWGCPDLVC YTDYLQTVICILEMWNLHPSTLTLT WQDQYEELKDEATSCSLHRSAHNAT HATYTCHMDVFHFMADDIFSVNITD QSGNYSQECGSFLLAESIKPAPPFN VTVTFSGQYNISWRSDYEDPAFYML KGKLQYELQYRNRGDPWAVSPRRKL ISVDSRSVSLLPLEFRKDSSYELQV RAGPMPGSSYQGTWSEWSDPVIFQT QSEELKEGWNPHLLLLLLLVIVFIP AFWSLKTHPLWRLWKKIWAVPSPER FFMPLYKGCSGDFKKWVGAPFTGSS LELGPWSPEVPSTLEVYSCHPPRSP AKRLQLTELQEPAELVESDGVPKPS FWPTAQNSGGSAYSEERDRPYGLVS IDTVTVLDAEGPCTWPCSCEDDGYP ALDLDAGLEPSPGLEDPLLDAGTTV LSCGCVSAGSPGLGGPLGSLLDRLK PPLADGEDWAGGLPWGGRSPGGVSE SEAGSPLAGLDMDTFDSGFVGSDCS SPVECDFTSPGDEGPPRSYLRQWVV IPPPLSSPGPQAS
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : IL21R interleukin 21 receptor [ Homo sapiens (human) ]
Official Symbol : IL21R
Synonyms : IL21R; interleukin 21 receptor; interleukin-21 receptor; CD360; IL-21R; IL-21 receptor; novel interleukin receptor; NILR; MGC10967;
Gene ID : 50615
mRNA Refseq : NM_021798
Protein Refseq : NP_068570
MIM : 605383
UniProt ID : Q9HBE5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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