Active Recombinant Human IL22RA1 Protein, His-tagged

• Cat.No.: IL22RA1-735H
• Product Overview: Recombinant Human IL22RA1 (Accession # NP_067081) Pro18-Thr228, fused with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived.

Specification

• Source: Mammalian cells
• Species: Human
• Tag: His
• Predicted N Terminal: Pro18
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells.The ED50 for this effect is typically 1 - 4 µg/mL in the presence of 1 ng/mL of rhIL-22.
• Molecular Mass: Recombinant Human IL22RA1, His-tagged has a calculated MW of 24.9 kDa. In SDS-PAGE migrates as 34-38 kDa, reducing conditions.
• Protein length: Pro18-Thr228
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information

• Gene Name: IL22RA1 interleukin 22 receptor, alpha 1 [ Homo sapiens ]
• Official Symbol: IL22RA1
• Synonyms: IL22RA1; interleukin 22 receptor, alpha 1; IL22R, interleukin 22 receptor; interleukin-22 receptor subunit alpha-1; CRF2 9; IL-22RA1; zcytoR11; IL-22R-alpha-1; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; IL22R; CRF2-9; IL22R1
• Gene ID: 58985
• mRNA Refseq: NM_021258
• Protein Refseq: NP_067081
• MIM: 605457
• UniProt ID: Q8N6P7
• Chromosome Location: 1p36.11

Reviews

12/18/2022

High stability in serum.

09/04/2017

Suitable for receptor binding.

10/16/2016

Effective in autoimmune studies.

Q&As

What post-translational modifications occur on IL22RA1?

IL22RA1 undergoes phosphorylation.

How does IL22RA1 contribute to IL22 signaling?

IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.

What impact do IL22RA1 polymorphisms have on disease susceptibility?

IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.

Is IL22RA1 involved in anti-tumor immunity?

IL22RA1 is involved in anti-tumor immunity by activating STAT3.

How does IL22RA1 expression change in autoimmune diseases?

IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.

How does IL22RA1 contribute to epithelial barrier function?

IL22RA1 enhances epithelial barrier function.

Is IL22RA1 expression tissue-specific?

IL22RA1 expression is tissue-specific, being high in the liver and skin.

Does IL22RA1 interact with other receptors?

IL22RA1 interacts with IL-10R2 and IL-20RB.

What is the affinity of IL22 for IL22RA1?

IL22 has high affinity for IL22RA1.

Does IL22RA1 have alternative splicing variants?

IL22RA1 has multiple alternative splicing variants.