Active Recombinant Canine IL22RA1, His-tagged

Cat.No. : IL22RA1-175C
Product Overview : A DNA sequence encoding the canine IL22RA1 (XP_855113.2) (Met1-The226) was expressed with a C-terminal polyhistidine tag.
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Source : Human Cells
Species : Canine
Tag : His
Form : Lyophilized from sterile PBS, pH7.4.
Bio-activity : Immobilized canine IL22RA1-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22, The EC50 of biotinylated IL22 is 0.23-0.55 μg/ml.
Molecular Mass : The recombinant canine IL22RA1 comprises 223 amino acids and has a predicted molecular mass of 25.6 kDa. The apparent molecular mass of the protein is approximately 36 kDa in SDS-PAGE under reducing conditions.
Protein length : Met1-The226
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >95 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : IL22RA1 interleukin 22 receptor, alpha 1 [ Canis lupus familiaris ]
Official Symbol : IL22RA1
Synonyms : IL22RA1; interleukin 22 receptor, alpha 1; interleukin-22 receptor subunit alpha-1;
Gene ID : 612279
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What post-translational modifications occur on IL22RA1? 11/18/2022

IL22RA1 undergoes phosphorylation.

How does IL22RA1 contribute to IL22 signaling? 03/01/2022

IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.

What impact do IL22RA1 polymorphisms have on disease susceptibility? 08/13/2021

IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.

Is IL22RA1 involved in anti-tumor immunity? 07/01/2021

IL22RA1 is involved in anti-tumor immunity by activating STAT3.

How does IL22RA1 expression change in autoimmune diseases? 05/25/2021

IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.

How does IL22RA1 contribute to epithelial barrier function? 04/28/2021

IL22RA1 enhances epithelial barrier function.

Is IL22RA1 expression tissue-specific? 05/21/2020

IL22RA1 expression is tissue-specific, being high in the liver and skin.

Does IL22RA1 interact with other receptors? 01/20/2020

IL22RA1 interacts with IL-10R2 and IL-20RB.

What is the affinity of IL22 for IL22RA1? 02/13/2016

IL22 has high affinity for IL22RA1.

Does IL22RA1 have alternative splicing variants? 01/05/2016

IL22RA1 has multiple alternative splicing variants.

Customer Reviews (3)

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Reviews
12/18/2022

    High stability in serum.

    09/04/2017

      Suitable for receptor binding.

      10/16/2016

        Effective in autoimmune studies.

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