Active Recombinant Human IL22RA1 protein, hFc-tagged

• Cat.No.: IL22RA1-780H
• Product Overview: Recombinant Human IL22RA1 protein(Q8N6P7)(His16-Thr228) is expressed from Expi293 with hFc tag at the C-terminal.

Specification

• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Supplied as 0.22μm filtered solution in PBS (pH 7.4). Please dilute to the desired concentration according to the concentration of the solution shown on the product label.
• Bio-activity: Immobilized Human IL-22, His Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC50 of 10.2ng/ml determined by ELISA.
• Molecular Mass: The protein has a predicted MW of 51 kDa. Due to glycosylation, the protein migrates to 60-68 kDa based on Tris-Bis PAGE result.
• Protein length: His16-Thr228
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE
  > 95% as determined by HPLC
• Storage: Valid for 12 months from date of receipt when stored at -80°C.
  Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: IL22RA1 interleukin 22 receptor, alpha 1 [ Homo sapiens ]
• Official Symbol: IL22RA1
• Synonyms: IL22RA1; interleukin 22 receptor, alpha 1; IL22R, interleukin 22 receptor; interleukin-22 receptor subunit alpha-1; CRF2 9; IL-22RA1; zcytoR11; IL-22R-alpha-1; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; IL22R; CRF2-9; IL22R1
• Gene ID: 58985
• mRNA Refseq: NM_021258
• Protein Refseq: NP_067081
• MIM: 605457
• UniProt ID: Q8N6P7

Reviews

12/18/2022

High stability in serum.

09/04/2017

Suitable for receptor binding.

10/16/2016

Effective in autoimmune studies.

Q&As

What post-translational modifications occur on IL22RA1?

IL22RA1 undergoes phosphorylation.

How does IL22RA1 contribute to IL22 signaling?

IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.

What impact do IL22RA1 polymorphisms have on disease susceptibility?

IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.

Is IL22RA1 involved in anti-tumor immunity?

IL22RA1 is involved in anti-tumor immunity by activating STAT3.

How does IL22RA1 expression change in autoimmune diseases?

IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.

How does IL22RA1 contribute to epithelial barrier function?

IL22RA1 enhances epithelial barrier function.

Is IL22RA1 expression tissue-specific?

IL22RA1 expression is tissue-specific, being high in the liver and skin.

Does IL22RA1 interact with other receptors?

IL22RA1 interacts with IL-10R2 and IL-20RB.

What is the affinity of IL22 for IL22RA1?

IL22 has high affinity for IL22RA1.

Does IL22RA1 have alternative splicing variants?

IL22RA1 has multiple alternative splicing variants.