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Recombinant Human IL22RA1 protein, His & T7-tagged

Cat.No. : IL22RA1-1320H
Product Overview : Recombinant Human IL22RA1 aa. (Gln267~Gly565 (Accession # Q8N6P7) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Description : The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 35.8kDa.
Protein length : Gln267~Gly565 (Accession # Q8N6P7)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.7.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : IL22RA1 interleukin 22 receptor subunit alpha 1 [ Homo sapiens (human) ]
Official Symbol : IL22RA1
Synonyms : IL22RA1; interleukin 22 receptor subunit alpha 1; IL22R; CRF2-9; IL22R1; interleukin-22 receptor subunit alpha-1; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; interleukin 22 receptor, alpha 1; zcytoR11
Gene ID : 58985
mRNA Refseq : NM_021258.3
Protein Refseq : NP_067081.2
UniProt ID : Q8N6P7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What post-translational modifications occur on IL22RA1? 11/18/2022

IL22RA1 undergoes phosphorylation.

How does IL22RA1 contribute to IL22 signaling? 03/01/2022

IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.

What impact do IL22RA1 polymorphisms have on disease susceptibility? 08/13/2021

IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.

Is IL22RA1 involved in anti-tumor immunity? 07/01/2021

IL22RA1 is involved in anti-tumor immunity by activating STAT3.

How does IL22RA1 expression change in autoimmune diseases? 05/25/2021

IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.

How does IL22RA1 contribute to epithelial barrier function? 04/28/2021

IL22RA1 enhances epithelial barrier function.

Is IL22RA1 expression tissue-specific? 05/21/2020

IL22RA1 expression is tissue-specific, being high in the liver and skin.

Does IL22RA1 interact with other receptors? 01/20/2020

IL22RA1 interacts with IL-10R2 and IL-20RB.

What is the affinity of IL22 for IL22RA1? 02/13/2016

IL22 has high affinity for IL22RA1.

Does IL22RA1 have alternative splicing variants? 01/05/2016

IL22RA1 has multiple alternative splicing variants.

Customer Reviews (3)

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Reviews
12/18/2022

    High stability in serum.

    09/04/2017

      Suitable for receptor binding.

      10/16/2016

        Effective in autoimmune studies.

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