Recombinant Human IL22RA1 protein, His & T7-tagged
Cat.No. : | IL22RA1-1320H |
Product Overview : | Recombinant Human IL22RA1 aa. (Gln267~Gly565 (Accession # Q8N6P7) fused with N-terminal His & T7 tag was produced in E. coli cells. |
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Description : | The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. |
Source : | E. coli |
Species : | Human |
Tag : | His&T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 35.8kDa. |
Protein length : | Gln267~Gly565 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 5.7. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | IL22RA1 interleukin 22 receptor subunit alpha 1 [ Homo sapiens (human) ] |
Official Symbol : | IL22RA1 |
Synonyms : | IL22RA1; interleukin 22 receptor subunit alpha 1; IL22R; CRF2-9; IL22R1; interleukin-22 receptor subunit alpha-1; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; interleukin 22 receptor, alpha 1; zcytoR11 |
Gene ID : | 58985 |
mRNA Refseq : | NM_021258.3 |
Protein Refseq : | NP_067081.2 |
UniProt ID : | Q8N6P7 |
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◆ Lysates | ||
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewHigh stability in serum.
Suitable for receptor binding.
Effective in autoimmune studies.
Q&As (10)
Ask a questionIL22RA1 undergoes phosphorylation.
IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.
IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.
IL22RA1 is involved in anti-tumor immunity by activating STAT3.
IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.
IL22RA1 enhances epithelial barrier function.
IL22RA1 expression is tissue-specific, being high in the liver and skin.
IL22RA1 interacts with IL-10R2 and IL-20RB.
IL22 has high affinity for IL22RA1.
IL22RA1 has multiple alternative splicing variants.
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