Recombinant Rat IL22RA1 Protein (Met1-Ala228), HlgG1 Fc-tagged

• Cat.No.: IL22RA1-955R
• Product Overview: Recombinant Rat IL22RA1 Protein (NP_001178798.1) (Met1-Ala228) was produced by HEK293 Cells expression system. This protein was expressed with the Fc region of human IgG1 at the C-terminus.

Specification

• Description: IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL2, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL1RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL2 and IL24 formed by IL22RA1 and IL2RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
• Source: HEK293
• Species: Rat
• Tag: Fc
• Predicted N Terminal: Thr 18
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant rat Il22ra1 consists 449 amino acids and predicts a molecular mass of 50.8 kDa.
• Protein length: Met1-Ala228
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: > 95 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade.
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
  Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: Il22ra1 interleukin 22 receptor, alpha 1 [ Rattus norvegicus ]
• Official Symbol: IL22RA1
• Synonyms: IL22RA1; interleukin 22 receptor, alpha 1; RGD1559655
• Gene ID: 362629
• mRNA Refseq: NM_001191869
• Protein Refseq: NP_001178798
• UniProt ID: D3ZIM3

Reviews

12/18/2022

High stability in serum.

09/04/2017

Suitable for receptor binding.

10/16/2016

Effective in autoimmune studies.

Q&As

What post-translational modifications occur on IL22RA1?

IL22RA1 undergoes phosphorylation.

How does IL22RA1 contribute to IL22 signaling?

IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.

What impact do IL22RA1 polymorphisms have on disease susceptibility?

IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.

Is IL22RA1 involved in anti-tumor immunity?

IL22RA1 is involved in anti-tumor immunity by activating STAT3.

How does IL22RA1 expression change in autoimmune diseases?

IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.

How does IL22RA1 contribute to epithelial barrier function?

IL22RA1 enhances epithelial barrier function.

Is IL22RA1 expression tissue-specific?

IL22RA1 expression is tissue-specific, being high in the liver and skin.

Does IL22RA1 interact with other receptors?

IL22RA1 interacts with IL-10R2 and IL-20RB.

What is the affinity of IL22 for IL22RA1?

IL22 has high affinity for IL22RA1.

Does IL22RA1 have alternative splicing variants?

IL22RA1 has multiple alternative splicing variants.