Active Recombinant Human IL22RA1, MIgG2a Fc-tagged
|Product Overview :||The extracellular domain of human IL-22RA1 (AAH29273.1)(Pro18-Thr228) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.|
- Gene Information
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|Description :||The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be areceptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein andinterleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10(IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in thechromosomal region 1p36.|
|Source :||CHO cell|
|Tag :||MIgG2a Fc-tagged|
|Form :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Bio-activity :||Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells.|
|Molecular Mass :||50KDa (monomer)|
|AA Sequence :||Pro18-Thr228|
|Endotoxin :||<0.06 eu/μg as determined by lal test.>0.06>|
|Purity :||>98%, by SDS-PAGE under reducing conditions.|
|Stability :||Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.|
|Reconstitution :||Reconstitute at 100μg/ml in sterile PBS.|
|Warning :||Avoid freeze/thaw cycles.|
|Gene Name :||IL22RA1 interleukin 22 receptor, alpha 1 [ Homo sapiens ]|
|Official Symbol :||IL22RA1|
|Synonyms :||IL22RA1; interleukin 22 receptor, alpha 1; IL22R, interleukin 22 receptor; interleukin-22 receptor subunit alpha-1; CRF2 9; IL-22RA1; zcytoR11; IL-22R-alpha-1; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; IL22R; CRF2-9; IL22R1;|
|Gene ID :||58985|
|mRNA Refseq :||NM_021258|
|Protein Refseq :||NP_067081|
|UniProt ID :||Q8N6P7|
|Chromosome Location :||1p36.11|
|Pathway :||Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;|
|Function :||interferon receptor activity; receptor activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL22RA1 undergoes phosphorylation.
IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.
IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.
IL22RA1 is involved in anti-tumor immunity by activating STAT3.
IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.
IL22RA1 enhances epithelial barrier function.
IL22RA1 expression is tissue-specific, being high in the liver and skin.
IL22RA1 interacts with IL-10R2 and IL-20RB.
IL22 has high affinity for IL22RA1.
IL22RA1 has multiple alternative splicing variants.
Customer Reviews (3)Write a review
High stability in serum. -
Suitable for receptor binding. -
Effective in autoimmune studies. -
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