Active Recombinant Human IL22RA1, MIgG2a Fc-tagged

• Cat.No.: IL22RA1-781H
• Product Overview: The extracellular domain of human IL-22RA1 (AAH29273.1)(Pro18-Thr228) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.

Specification

• Description: The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be areceptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein andinterleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10(IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in thechromosomal region 1p36.
• Source: CHO cell
• Species: Human
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells.
• Molecular Mass: 50KDa (monomer)
• AA Sequence: Pro18-Thr228
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL22RA1 interleukin 22 receptor, alpha 1 [ Homo sapiens ]
• Official Symbol: IL22RA1
• Synonyms: IL22RA1; interleukin 22 receptor, alpha 1; IL22R, interleukin 22 receptor; interleukin-22 receptor subunit alpha-1; CRF2 9; IL-22RA1; zcytoR11; IL-22R-alpha-1; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; IL22R; CRF2-9; IL22R1
• Gene ID: 58985
• mRNA Refseq: NM_021258
• Protein Refseq: NP_067081
• MIM: 605457
• UniProt ID: Q8N6P7
• Chromosome Location: 1p36.11
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: interferon receptor activity; receptor activity