Il25
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Official Full Name
interleukin 25
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Background
IL-25 is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-κB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17RB. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. IL-25 is a cytokine that belongs to the IL-17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells. It is also known as IL-17E. -
Synonyms
IL25; interleukin 25; interleukin 17E; IL17E; IL-25; IL-17E; Interleukin-25; UNQ3120/PRO10272; Interleukin-17E;
- Involved Pathway
- Protein Function
- Interacting Protein
- Il25 Related Research Area
Il25 involved in several pathways and played different roles in them. We selected most pathways Il25 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF8;CCR9;LIF;TNFRSF9;TNFSF8;TNFSF12;IFNPHI3;CXCL1;IFNB |
Il25 has several biochemical functions, for example, cytokine activity, interleukin-17E receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il25 itself. We selected most functions Il25 had, and list some proteins which have the same functions with Il25. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | Gm13290;GPI;LEFTY2;Cxcl15;GREM1A;CMTM6;CCL38A.4;IFNT2;Kitl |
| interleukin-17E receptor binding |
Il25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il25 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il25.
ESR1
- Q&As
- Reviews
Q&As (6)
Ask a questionThere is a lack of conclusive evidence that IL-25 has a clear effect in tumor treatment, but there are some studies underway.
There are no clear studies on the side effects of IL-25, but the patient response needs to be closely monitored during research and clinical application.
In addition to treating asthma and inflammatory bowel disease, IL-25 may also have potential applications in the treatment of lung infections, urticaria and other diseases.
IL-25 activates specific signaling pathways by binding to specific receptors, thereby regulating the activity of immune cells and the degree of inflammation in the body.
Some studies have shown that recombinant IL-25 can improve symptoms of diseases such as asthma and inflammatory bowel disease, but more research is needed to verify its efficacy.
Yes, in general, IL-25 therapy needs to be administered by injection to ensure that the protein can enter the body and work.
Customer Reviews (3)
Write a reviewEfficacy of the protein can be evaluated by observing its pharmacokinetics, pharmacodynamics and toxicity in mice or rats. -
Animal models were used to evaluate the efficacy and side effects of the remade proteins. -
Storage is stable, and the environmental requirements are not harsh. -
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