Recombinant Active Human IL25 Protein, His-tagged(C-ter)

Cat.No. : IL25-182H
Product Overview : Recombinant Active Human IL25 Protein with His tag (C-ter) was expressed in E. coli.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Source : E. coli
Species : Human
Tag : His(C-ter)
Form : Powder
Bio-activity : Determined by its ability to induce IL-8 secretion in human PBMCs. The ED50 for this effect is < 5 ng/mL. Determined by its ability to induce CXCL1 secretion in HT29 cells. The ED50 for this effect is < 1 ng/mL.
AA Sequence : MYSHWPSCCPSKGQDTSEELLRWST VPVPPLEPARPNRHPESCRASEDGP LNSRAISPWRYELDRDLNRLPQDLY HARCLCPHCVSLQTGSHMDPRGNSE LLYHNQTVFYRRPCHGEKGTHKGYC LERRLYRVSLACVCVRPRVMG
Endotoxin : Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
Purity : > 98% (by SDS-PAGE)
Applications : SDS-PAGE
Notes : For laboratory research only, not for drug, diagnostic or other use.
Storage : Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Storage Buffer : PBS (pH 8.0)
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
Gene Name : IL25 interleukin 25 [ Homo sapiens ]
Official Symbol : IL25
Synonyms : IL25; interleukin 25; IL17E, interleukin 17E; interleukin-25; IL 17E; IL 25; interleukin 17E; interleukin-17E; IL17E;
Gene ID : 64806
mRNA Refseq : NM_022789
Protein Refseq : NP_073626
MIM : 605658
UniProt ID : Q9H293

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there any research showing that IL-25 is effective in tumor treatment? 12/10/2022

There is a lack of conclusive evidence that IL-25 has a clear effect in tumor treatment, but there are some studies underway.

Are there any side effects to IL-25? 09/22/2021

There are no clear studies on the side effects of IL-25, but the patient response needs to be closely monitored during research and clinical application.

Has the study found potential applications of IL-25 in the treatment of other diseases? 01/18/2021

In addition to treating asthma and inflammatory bowel disease, IL-25 may also have potential applications in the treatment of lung infections, urticaria and other diseases.

What is the mechanism of action of IL-25? 12/18/2020

IL-25 activates specific signaling pathways by binding to specific receptors, thereby regulating the activity of immune cells and the degree of inflammation in the body.

Is there any research showing that IL-25 is effective against certain diseases? 08/17/2020

Some studies have shown that recombinant IL-25 can improve symptoms of diseases such as asthma and inflammatory bowel disease, but more research is needed to verify its efficacy.

Does IL-25 therapy need to be administered by injection? 03/28/2019

Yes, in general, IL-25 therapy needs to be administered by injection to ensure that the protein can enter the body and work.

Customer Reviews (3)

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Reviews
01/29/2021

    Efficacy of the protein can be evaluated by observing its pharmacokinetics, pharmacodynamics and toxicity in mice or rats. -

    08/31/2019

      Animal models were used to evaluate the efficacy and side effects of the remade proteins. -

      01/05/2019

        Storage is stable, and the environmental requirements are not harsh. -

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