Recombinant Active Human IL25 Protein, His-tagged(C-ter)
|Product Overview :||Recombinant Active Human IL25 Protein with His tag (C-ter) was expressed in E. coli.|
- Gene Information
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|Description :||The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]|
|Source :||E. coli|
|Bio-activity :||Determined by its ability to induce IL-8 secretion in human PBMCs. The ED50 for this effect is < 5 ng/mL. Determined by its ability to induce CXCL1 secretion in HT29 cells. The ED50 for this effect is < 1 ng/mL.|
|AA Sequence :||MYSHWPSCCPSKGQDTSEELLRWST VPVPPLEPARPNRHPESCRASEDGP LNSRAISPWRYELDRDLNRLPQDLY HARCLCPHCVSLQTGSHMDPRGNSE LLYHNQTVFYRRPCHGEKGTHKGYC LERRLYRVSLACVCVRPRVMG|
|Endotoxin :||Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.|
|Purity :||> 98% (by SDS-PAGE)|
|Notes :||For laboratory research only, not for drug, diagnostic or other use.|
|Storage :||Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.|
|Storage Buffer :||PBS (pH 8.0)|
|Reconstitution :||It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.|
|Gene Name :||IL25 interleukin 25 [ Homo sapiens ]|
|Official Symbol :||IL25|
|Synonyms :||IL25; interleukin 25; IL17E, interleukin 17E; interleukin-25; IL 17E; IL 25; interleukin 17E; interleukin-17E; IL17E;|
|Gene ID :||64806|
|mRNA Refseq :||NM_022789|
|Protein Refseq :||NP_073626|
|UniProt ID :||Q9H293|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
There is a lack of conclusive evidence that IL-25 has a clear effect in tumor treatment, but there are some studies underway.
There are no clear studies on the side effects of IL-25, but the patient response needs to be closely monitored during research and clinical application.
In addition to treating asthma and inflammatory bowel disease, IL-25 may also have potential applications in the treatment of lung infections, urticaria and other diseases.
IL-25 activates specific signaling pathways by binding to specific receptors, thereby regulating the activity of immune cells and the degree of inflammation in the body.
Some studies have shown that recombinant IL-25 can improve symptoms of diseases such as asthma and inflammatory bowel disease, but more research is needed to verify its efficacy.
Yes, in general, IL-25 therapy needs to be administered by injection to ensure that the protein can enter the body and work.
Customer Reviews (3)Write a review
Efficacy of the protein can be evaluated by observing its pharmacokinetics, pharmacodynamics and toxicity in mice or rats. -
Animal models were used to evaluate the efficacy and side effects of the remade proteins. -
Storage is stable, and the environmental requirements are not harsh. -
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